Molecular mechanism underlying orofacial antinociceptive activity of Vanillosmopsis arborea Baker (Asteraceae) essential oil complexed with β-cyclodextrin

Leite, Laura Hévila Inocêncio; Leite, Gerlânia O.; Silva, Bruno Anderson Fernandes da; Santos, Sacha Aubrey Alves Rodrigues; Magalhães, Francisco Ernani Alves; Menezes, Paula P.; Serafini, Mairim Russo; Teixeira, Claudener S.; Brito, Renan Guedes de; Santos, Priscila L.; Costa, José Galberto Martins da; Araújo, Adriano A. S.; Menezes, Irwin Rose Alencar de; Coutinho, Henrique Douglas Melo; Campos, Adriana Rolim

doi:10.1016/j.phymed.2018.09.173

Cited by 12 publications

(10 citation statements)

References 32 publications

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“…Fos protein expression in the dorsal horn of the spinal cord was decreased by pCDEVA, inferring a reduction in pain-sensitive neuronal activation. In the same study, (through molecular docking) the researchers observed favorable interactions between bisabolol, the major constituent of EOVA, the 5-HT3 receptor, and type 3 muscarinic receptors (Leite et al, 2019).…”

Section: Vanillosmopsis Arborea Bakermentioning

confidence: 84%

“…The most prominent plant families used in the studies identified were Asteraceae, (Garcıá et al, 2011;Radulovićet al, 2015;Leite et al, 2019); Euphorbiaceae, de Oliveira junior et al, 2018); Verbenaceae, (Siqueira-Lima et al, 2017); Lamiaceae, (Quintans-Junior et al, 2018), and Lauraceae (Sumiwi et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

“…Of the species, Croton conduplicatus Kunth prevailed de Oliveira junior et al, 2018); with Vanillosmopsis arborea Baker (Leite et al, 2019); then Achillea falcata L.; (Radulovićet al, 2015); Ageratin glabrata; (Garcıá et al, 2011); Hyptis pectinata; (Quintans-Junior et al, 2018); Cinnamomum; sintoc bl. ; (Sumiwi et al, 2015); and Grateful Lippia Schauer (Siqueira-Lima et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…Assis et al (Santos et al, 2016;Gouveia et al, 2018Santos et al, 2019. The in silico programs used for docking studies were; Molegro Virtual Docker (Oliveira et al, 2016;Siqueira-Lima et al, 2017;de Oliveira Juńior et al, 2018;Gouveia et al, 2018;Leite et al, 2019;Santos et al, 2019); Sybyl ® X software suite (Garcıá et al, 2011), Vlife MDS (Kerzare et al, 2016); AutoDock Vina (Santos et al, 2016); Hex Protein Docking (HEX) (Teixeira et al, 2017;Melo et al, 2017); and AutoDock 4.2 software in PyRx 0.9 (Silva et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…The molecular targets/complexes used in the docking studies were Nitric Oxide Synthase (Gouveia et al, 2018), COX-2 (Garcıá et al, 2011;Sumiwi et al, 2015;Kerzare et al, 2016); GluR2-S1S2 (Santos et al, 2016); TRPV1 (Teixeira et al, 2017;Melo et al, 2017); b-CD complex (Silva et al, 2017); CaV1, CaV2.1, CaV2.2, and CaV2.3 (Santos et al, 2019); 5-HT receptor, Delta receptor, Kappa receptor, and MU (µ) receptor (Oliveira et al, 2016); Alpha Adrenergic, Opioid, and Serotonergic receptors (Siqueira-Lima et al, 2017); Muscarinic receptors and GABA A (De Oliveira Junior et al, 2017; de Oliveira Juńior et al, 2018); Opioid and Serotonin receptors (Quintans-Junior et al, 2018); 5-HT 3 and M2 receptors (Leite et al, 2019).…”

Section: Docking Of Antinociceptive Essential Oilsmentioning

confidence: 99%

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Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review

et al. 2020

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Introduction: Pain is considered an unpleasant sensory and emotional experience, being considered as one of the most important causes of human suffering. Computational chemistry associated with bioinformatics has stood out in the process of developing new drugs, through natural products, to manage this condition. Objective: To analyze, through literature data, recent molecular coupling studies on the antinociceptive activity of essential oils and monoterpenes. Data source: Systematic search of the literature considering the years of publications between 2005 and December 2019, in the electronic databases PubMed and Science Direct. Eligibility Criteria: Were considered as criteria of 1) Biological activity: non-clinical effects of an OE and/or monoterpenes on antinociceptive activity based on animal models and in silico analysis, 2) studies with plant material: chemically characterized essential oils and/or their constituents isolated, 3) clinical and non-clinical studies with in silico analysis to assess antinociceptive activity, 4) articles published in English. Exclusion criteria were literature review, report or case series, meta-analysis, theses, dissertations, and book chapter. Results: Of 16,006 articles, 16 articles fulfilled all the criteria. All selected studies were non-clinical. The most prominent plant families used were Asteraceae, Euphorbiaceae, Verbenaceae, Lamiaceae, and Lauraceae. Among the phytochemicals studied were a-Terpineol, 3-(5-substituted-1,3,4-oxadiazol-2-yl)-N′-[2-oxo-1,2-dihydro-3H-indol-3ylidene] propane hydrazide, b-cyclodextrin complexed with citronellal, (−)-a-bisabolol, b-cyclodextrin complexed with farnesol, and p-Cymene. The softwares used for docking studies were Molegro Virtual Docker, Sybyl ® X, Vlife MDS, AutoDock Vina, Hex Protein Docking, and AutoDock 4.2 in PyRx 0.9. The molecular targets/complexes used were Nitric Oxide Synthase, COX-2, GluR2-S1S2, TRPV1, b-CD complex, CaV 1 , CaV 2.1 , CaV 2.2 , and CaV 2.3 , 5-HT receptor, delta receptor, kappa receptor, and MU (m)

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Section: Vanillosmopsis Arborea Bakermentioning

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Docking Of Antinociceptive Essential Oilsmentioning

confidence: 99%

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Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review

et al. 2020

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Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain

Kwankaew

Okuda

Aye-Mon

et al. 2021

European Journal of Pain

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Background: Neuropathic pain (NeP) medications have several side effects that affect NeP patients' quality of life. Betanin, the most common betacyanin pigment, has been shown to have potent antioxidant and anti-inflammatory properties in vivo; thus, it has potential as a healthcare treatment. In this study, we focused on betanin (red beetroot extract) as a potential therapy for NeP. Methods: Mice model of NeP were made by chronic constriction injury (CCI), and the development of mechanical hypersensitivity was confirmed using the von Frey test. Motor coordination and locomotor activity were assessed using open field tests and rotarod tests, respectively. The expression level of glial markers in the spinal cords was analyzed by immunostaining. The direct effects of betanin on microglial cells were investigated using primary cultured microglial cells. Results: In CCI model mice, repeated betanin treatment, both intraperitoneally and orally, attenuated developing mechanical hypersensitivity in a dose-dependent manner without impairing motor coordination. Betanin treatment also attenuated mechanical hypersensitivity that had developed and prevented the onset of mechanical hypersensitivity in CCI mice. Microglial activation in the spinal cord is known to play a key role in the development of NeP; betanin treatment reduced CCI-induced microglial activation in the spinal cord of model mice. Moreover, in primary microglia cultured cells, the activation of microglia by lipopolysaccharide application was suppressed by betanin treatment. Conclusion: Betanin treatment appears to ameliorate mechanical hypersensitivity related to CCI-induced NeP in mice by inhibiting microglial activation. Significance: This article supports findings of the effect of betanin on NeP and provides a potential therapeutic candidate for NeP. Furthermore, elucidating the underlying mechanism of the effect of betanin on microglial activation could assist the development of new treatments for chronic pain. How to cite this article: Kwankaew N, Okuda H, Aye-Mon A, et al. Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain.

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Essential Oils as Effective Agents Against Neurological Disorders

Pai

Sonkamble

Wagh

2020

Plant-Derived Bioactives

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Molecular mechanism underlying orofacial antinociceptive activity of Vanillosmopsis arborea Baker (Asteraceae) essential oil complexed with β-cyclodextrin

Cited by 12 publications

References 32 publications

Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review

Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review

Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain

Essential Oils as Effective Agents Against Neurological Disorders

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