Molecular mechanism of poor embryo development in postovulatory aged oocytes: Mini review

Takahashi, Toshifumi; Igarashi, Hideki; Amita, Mitsuyoshi; Hara, Shuichiro; Matsuo, Keitaro; Kurachi, Hirohisa

doi:10.1111/jog.12111

Cited by 71 publications

(68 citation statements)

References 61 publications

(166 reference statements)

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“…Most authors suggest that an increase in reactive oxygen species (ROS) is involved in postovulatory oocyte ageing (Figure 2). ROS are chemically reactive molecules containing oxygen, such as oxygen ions and peroxides, which may act as an initiator for over-ripening in human Takahashi et al, 2013) and mouse oocytes . Therefore, an increase in the ROS levels of the oocyte could be associated with the progress of ageing (Takahashi et al, 2003;Tatone et al, 2011).…”

Section: Egg Cellular and Molecular Changes Through Oocyte Ageingmentioning

confidence: 99%

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Fish Oocyte Ageing and its Effect on Egg Quality

Samarin

Policar

Lahnsteiner

2015

Reviews in Fisheries Science & Aquaculture

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In fish, delayed spawning in nature, delayed egg collection in capture and delayed fertilization after egg stripping can lead to oocyte ageing and over-ripening. Oocyte ageing is reported as one of the most important factors affecting the egg quality. During over-ripening, morphological, physiological, biochemical, histological, cellular, and molecular changes occur inside the eggs and ovarian fluid. These alterations can negatively affect the egg fertilization capacity and successive developmental stages. The time period during which eggs remain viable after ovulation or stripping has been reported from a few minutes to a few weeks depending on the fish species and the storage temperature. Although several biomarkers that characterize the over-ripening phenomenon have been defined, the reliability of these parameters in the field of aquaculture is controversial. For future researches, inhibition of oocyte ageing by antioxidants could be a valuable research topic. In the present article, the morphological, physiological, biochemical, histological, cellular, and molecular changes that occur during oocyte over-ripening under in vivo conditions and during in vitro storage are reviewed and possible reasons for the decrease in viability of eggs are presented. Species-specific changes in the egg viability and larval development are also considered.

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Section: Egg Cellular and Molecular Changes Through Oocyte Ageingmentioning

confidence: 99%

“…This can have consequences for different Figure 2. Schematic of the mechanism of poor embryo development in post-ovulatory oocyte ageing (obtained from Takahashi et al, 2013).…”

Section: Egg Cellular and Molecular Changes Through Oocyte Ageingmentioning

confidence: 99%

Fish Oocyte Ageing and its Effect on Egg Quality

Samarin

Policar

Lahnsteiner

2015

Reviews in Fisheries Science & Aquaculture

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“…Increased plasma and FF oxidative stress markers and decreased levels of antioxidants have been already related to poor in vitro fertilization (IVF) outcome [39][40][41]. Indeed, several studies reported the relationship between follicular development, poor oocyte quality and fertilization, embryonic development, and decreased female fertility and oxidative stress, both at systemic and local level.…”

Section: Discussionmentioning

confidence: 99%

A New Biochemical Approach to Detect Oxidative Stress in Infertile Women Undergoing Assisted Reproductive Technology Procedures

Becatti¹,

Fucci²,

Mannucci³

et al. 2018

Preprint

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Oxidative stress negatively affects folliculogenesis and embryo development. However, a reliable and biologically accurate indicator of oxidative stress does not yet exist. On these bases, the aim of this study was to assess -and compare-blood and follicular fluid (FF) redox status in 45 infertile subjects (and 45 age-matched controls) undergoing in vitro fertilization (IVF) and to establish its connection with the outcome of IVF. Blood and FF were obtained at the time of egg retrieval and immediately analyzed. Firstly, ROS production in blood leukocytes and in granulosa cells was assessed. Oxidative stress markers in blood and in granulosa cells resulted significantly (p<0.001) increased in infertile patients compared to controls. Then, a redox index was obtained in plasma and in FF of patients and controls. The main findings emerging from our study in infertile women are: i) blood oxidative stress reflects FF oxidative stress as demonstrated by the significant correlation between blood redox markers and FF redox markers; ii) a significant correlation between oxidative stress parameters and the considered IVF outcomes is present. We suggest the strict monitoring of the redox parameters for the improvement of assisted reproductive techniques success rate and infertility management.

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“…Similarly, aged oocytes have lowering CSF levels due to gradual decay, destabilizing MPF, leading to an increase in spontaneous activation by physicochemical environmental events (Wakayama et al, 2003). However, despite being easier to activate, aged oocytes have lower potential for further embryo development (Chian et al, 1992;Takahashi, 2013).…”

Section: Universal Cytoplastmentioning

confidence: 99%

Probability, odds and random chance: the difficult task of modulating the epigenetic profile of cloned embryos

et al. 2017

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Since the beginning of modern embryology, scientists have wondered about how a small number of totipotent embryonic cells can become an individual with a wide variety of organs and tissues with distinct functions. Also, the idea of generating a cloned animal using a nucleus from a donor cell is not recent. However, it has taken years of research to achieve this goal, especially regarding mechanisms of cell reprogramming required to return a differentiated cell to totipotency. Cloning by somatic cell nuclear transfer (SCNT) has been a valuable tool to understand epigenetic mechanisms related to cellular reprogramming. However, cloning efficiency is still low, with a low percentage of embryos resulting in healthy animals. The high attrition rate is associated with incomplete or abnormal epigenetic reprogramming, such that many cloned embryos have DNA methylation patterns different than controls, resulting in faulty gene expression and subsequent developmental failures. Attempts to improve genome reprogramming by modulation of oocyte quality and/or somatic cell plasticity, thereby increasing cloning efficiency and preventing detrimental effects on development, have proven ineffective. The recent development of DNA editing techniques may facilitate an improved understanding of cellular reprogramming and the role of DNA methylation in development. These novel tools may lead to new means to modulate epigenetic programming and inheritance, and hold great promise to assist in epigenetic remodeling of the donor nucleus. Such strategies are likely to improve the odds for successful cloning.

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Molecular mechanism of poor embryo development in postovulatory aged oocytes: Mini review

Cited by 71 publications

References 61 publications

Fish Oocyte Ageing and its Effect on Egg Quality

Fish Oocyte Ageing and its Effect on Egg Quality

A New Biochemical Approach to Detect Oxidative Stress in Infertile Women Undergoing Assisted Reproductive Technology Procedures

Probability, odds and random chance: the difficult task of modulating the epigenetic profile of cloned embryos

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