Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Abstract

Functional ingredients in blueberry have the best health benefits. To obtain a better understanding of the health role of blueberry in chronic disease, we conducted systematic preventive strategies for functional ingredients in blueberry, based on comprehensive databases, especially PubMed, ISI Web of Science, and CNKI for the period 2008–2018. Blueberry is rich in flavonoids (mainly anthocyanidins), polyphenols (procyanidin), phenolic acids, pyruvic acid, chlorogenic acid, and others, which have anticancer, anti-obesity, prevent degenerative diseases, anti-inflammation, protective properties for vision and liver, prevent heart diseases, antidiabetes, improve brain function, protective lung properties, strong bones, enhance immunity, prevent cardiovascular diseases, and improve cognitive decline. The anthocyanins and polyphenols in blueberry are major functional ingredients for preventive chronic disease. These results support findings that blueberry may be one of the best functional fruits, and further reveals the mechanisms of anthocyanins and polyphenols in the health role of blueberry for chronic disease. This paper may be used as scientific evidence for developing functional foods, nutraceuticals, and novel drugs of blueberry for preventive chronic diseases.

Time-Dependent Degradation of Polyphenols from Thermally-Processed Berries and Their In Vitro Antiproliferative Effects against Melanoma

“…For the in vitro test we have obtained promising results which can be compared with available published data. Many studies have proved that anthocyanins present beneficial effects for human health [ 47 ]. Because of their physiological activities, the consumption of anthocyanins may play a significant role in preventing lifestyle-related diseases such as cancer, diabetes, cardiovascular and neurological disease.…”

Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease

“…7 It has been shown that blueberries play an important role in hepatic protection and hepatic fibrosis reversal. 8 Moreover, an increasing number of studies have revealed that probiotics act as a complementary therapeutic method in NAFLD. 9 However, little is known about the impacts of blueberry juice combined with probiotics (BP) on NAFLD.…”

Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases

“…Anthocyanin belongs to flavonoids, and flavonoids belongs to polyphenols. Black, purple, and blue barley grains have gained much attention recently because their anthocyanins have anticancer, glycemic and body weight regulation, antioxidation, anti-inflammation, neuroprotection, hypolipidemia, retinal protection, hepatoprotection, and antiaging effects [150,151].…”

“…The worldwide daily consumption of fruits and vegetables as well as tea has become the main tool for prevention of cardiovascular disease, stroke, cancer and diabetes due to their polyphenols modulate tau hyperphosphorylation and beta amyloid aggregation [178]. The anthocyanins and polyphenols for major functional ingredients in blueberry played a key role in preventing 15 chronic diseases [151]. The organopolysulfides and quercetin for major functional ingredients in Allium genus played a key role in preventing 10 chronic diseases [179].…”