Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases

Zeng, Yawen; Pu, Xiaoying; Du, Juan; Yang, Xiaomeng; Li, Xia; Mandal, Md. Siddikun Nabi; Yang, Tao; Yang, Jia-Zhen

doi:10.1155/2020/3836172

Cited by 71 publications

(84 citation statements)

References 211 publications

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“…Polyphenols are bioactive compounds that extensively existed in plant foods and have many health-promoting effects by the different mechanisms, such as antioxidation, anti-inflammation, immunomodulation, and modulating gut microbiota [11,13]. Resveratrol is a natural phenolic compound and has been found in many foods, such as grapes, peanuts, blueberries, and red wine.…”

Section: Introductionmentioning

confidence: 99%

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Zhou

Luo

Huang

et al. 2021

Oxidative Medicine and Cellular Longevity

158

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The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.

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Section: Introductionmentioning

confidence: 99%

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Zhou

Luo

Huang

et al. 2021

Oxidative Medicine and Cellular Longevity

158

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“…Interaction studies demonstrated the binding of RSV to various F I G U R E 1 Chemical structure of trans-and cis-resveratrol (from Gambini et al, 2015) targets including tubulin, protein kinase C alpha (PKCα), phosphodiesterase-4D, human oral cancer cell line proteins, DNA sequences having AATT/TTAA segments, PKCα, lysine-specific demethylase 1 (Kataria & Khatkar, 2019). Furthermore, RSV targets multiple intracellular signalling substances and pathways including adenosine monophosphate kinase, nuclear factor-κB, inflammatory prostaglandins and cytokines, anti-oxidant enzymes-regulators of apoptosis, mitochondrial biogenesis, gluconeogenesis and lipid metabolism (Meng et al, 2021;Moraes, Moreira, Andrade, & Santos, 2020;Pannu & Bhatnagar, 2019;Zeng et al, 2020). These target molecules can be intracellular mediators of RSV action, although the mediatory role of some of them still require experimental confirmation.…”

Section: Mechanisms Of Rsv Actionmentioning

confidence: 99%

Effects of resveratrol on female reproduction: A review

Sirotkin

2021

Phytotherapy Research

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The present review summarizes the current knowledge concerning physiological effects of resveratrol (RSV) with emphasis on the RSV action on female reproductive processes. The review outlines provenance, properties, mechanisms of action, physiological and therapeutic actions of RSV on female reproduction and other physiological processes, as well as areas of possible application of R. This review is based on the search for the related full papers indexed in Medline/Pubmed, Web of Science and SCOPUS databases between the year 2000 and 2021 according to the criteria of preferred reporting items for systematic reviews and meta‐analyses extension for scoping reviews and other related guidelines. The analysis of the available information suggests that RSV has a number of properties which enable its influence on various physiological processes including female reproduction at various regulatory levels via various extra‐ and intracellular signalling pathways. Despite some contradictions and limitations in the available data, they indicate applicability of both stimulatory and inhibitory effects of RSV for control and influence of various reproductive and non‐reproductive processes and treatment of their disorders in phytotherapy, animal production, medicine, biotechnology and assisted reproduction. To establish the clinical efficacy of RSV, further high quality studies are needed.

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“…This can open up opportunities for discussions and for industrial sectors to retain some value and benefits in the final products in the GVCs market. However, food health effects [65] should be investigated to incorporate SDGs' good health and wellbeing targets.…”

Section: Limitationsmentioning

confidence: 99%

Food Security Sustainability: A Synthesis of the Current Concepts and Empirical Approaches for Meeting SDGs

et al. 2021

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Currently, food security is becoming a fundamental problem in the global macroeconomic dynamics for policymakers and governments in developing countries. Globally, food security offers challenges both from achieving Sustainable Development Goals (SDGs) targets and the welfare perspective of many poor households. As a result, this study is guided by Neo Malthusian and Access theories to investigate Food Security Sustainability: a Synthesis of the Current Concepts and Empirical Approaches for Meeting SDGs in Nigeria using ARDL and ECM techniques. The ARDL revealed that agricultural value-added and GDP positively affect food security for commercial agrarian investments in Nigeria. However, internal displacement, population growth, food inflation, and exchange rate volatility negatively affect sustainable food security in Nigeria. The model’s coefficient of ECMt−1 also shows negative (−0.0130 approximately) and statistically significant (0.0000) at 1%. Thus, the speed of adjustment requires 1.3% annually for the long-run equilibrium convergence to be restored. The study concludes that the SDGs targets for poverty and hunger reduction, mainly for food security sustainability alongside small producers by the year 2030, can be rarely achieved because the convergence to equilibrium is more than nine years. An active value-addition strategy for sustainable food security and the provision of humanitarian interventions are recommended.

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Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases

Cited by 71 publications

References 211 publications

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Effects of resveratrol on female reproduction: A review

Food Security Sustainability: A Synthesis of the Current Concepts and Empirical Approaches for Meeting SDGs

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