Molecular level studies on interfacial hydration of zwitterionic and other antifouling polymers in situ

Leng, Chuan; Sun, Shuchen; Zhang, Kexin; Jiang, Shaoyi; Chen, Zhan

doi:10.1016/j.actbio.2016.02.030

Cited by 161 publications

(198 citation statements)

References 82 publications

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“…In addition, MPC and MPC polymers have been commercialized worldwide as reagents and as base of new polymer designs with even better performance or novel features. Recently, MPC polymer‐like zwitterionic polymers, such as those based on sulfobetaine and carboxybetaine, have been synthesized and evaluated as the potential for biomaterials . It is expected that continued research into polymer biomaterials will advance minimally invasive medical care and regenerative medicine in support of an aging society.…”

Section: Notes and Future Perspectivementioning

confidence: 99%

“…Recently, MPC polymer-like zwitterionic polymers, such as those based on sulfobetaine and carboxybetaine, have been synthesized and evaluated as the potential for biomaterials. 67,[123][124][125][126][127] It is expected that continued research into polymer biomaterials will advance minimally invasive medical care and regenerative medicine in support of an aging society.…”

Section: Notes and Future Perspectivementioning

confidence: 99%

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Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Ishihara

2019

J Biomedical Materials Res

166

167

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In the last 40 years, many strategies to fabricate biocompatible and antithrombogenic polymers have been proposed, especially in Japan. The development of one such polymers composed of 2‐methacryloyloxyethyl phosphorylcholine unit, is described in this review, with specific examples of use in biomedical devices. These polymers are typically incorporated into other materials to effectively prevent unfavorable biological responses and reactions. For example, the polymers suppress protein adsorption and cell adhesion to materials in contact with plasma or whole blood, even in the absence of anticoagulant. These properties are due to the extreme hydrophilicity and electrically neutral nature of the polymers, as well as to the ability of phosphorylcholine to induce bulk‐like behavior in surrounding waters. Accordingly, these polymers have been used worldwide to modify the surfaces and improve the overall biocompatibility of such medical devices as long‐term implantable artificial organs. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 933–943, 2019.

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Section: Notes and Future Perspectivementioning

confidence: 99%

Section: Notes and Future Perspectivementioning

confidence: 99%

Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Ishihara

2019

J Biomedical Materials Res

166

167

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“…S23C †). In agreement with hydrogel cloud points, the equilibrium swelling ratio of P(EG) x MA hydrogels [4][5] MA hydrogels (5 wt% in PBS) defined as the onset of turbidity (600 nm). No cloud point was observed for P(EG) [8][9] MA gels.…”

Section: Hydrogel Gelation and Characterizationmentioning

confidence: 63%

“…6). Degradation rates were controlled by polymer hydration (P(EG) 3 MA, P(EG) [4][5] MA, and P(EG) [8][9] MA) and the acidity of the crosslinker's b-hydrogen by exchanging EWG groups (4methylphenyl sulfone or 4-chlorophenyl sulfone). Because PEG M W inuenced degradation rates ( Fig.…”

Section: Tunable Degradation Of P(eg) X Ma Hydrogelsmentioning

confidence: 99%

“…3 Due to their strong hydration shells, non-specic protein adhesion to low-fouling polymers such as poly(oligo(ethylene glycol) x methyl ether methacrylate) (P(EG) x MA) and poly-(carboxybetaine methacrylamide) (PCBMAA) is energetically unfavorable. 4 P(EG) [4][5] MA coated surfaces resist protein fouling 5 and platelet binding. 6 Moreover, carboxybetaine coated surfaces have been shown to prevent non-specic protein adsorption in serum 7 and resist the FBR for up to 3 months in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Controlled degradation of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) hydrogels

et al. 2019

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Synthesis of a Stretchable Polyampholyte Hydrophilic Film with Compositional Gradient for Long‐Term Stable, Substrate‐Independent Fouling‐Resistant Coating

Kim

Song

Park

et al. 2022

Adv Funct Materials

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The prevention of nonspecific biofouling is crucial for technological development in biomaterials and medical devices. Thus, zwitterionic materials have attracted significant attention due to their effective fouling‐resistance, long‐term durability against oxidation, and biocompatibility. However, fabricating a substrate‐independent zwitterionic surface with outstanding fouling‐resistance remains a challenge. In this study, a polyampholyte coating that satisfies the aforementioned requirements is obtained using a vapor‐phase method. The polyampholyte coating consists of a bilayer of poly(1,3,5,7‐tetramethyl‐1,3,5,7‐tetravinyl cyclotetrasiloxane) (pV4D4) and polyampholyte, poly(2‐carboxyethyl acrylate‐co‐2‐(dimethylamino)ethyl acrylate) (pCD), stacked with compositional gradient, which are obtained via sequential deposition using initiated chemical vapor deposition. The heavily crosslinked pV4D4 acts as an adhesion promoter layer that may be applied conformally to various substrate materials with high interfacial adhesion. The pCD surface exhibits a long‐lasting, superior fouling‐resistance to proteins (20.3 ± 1.8 ng cm−2 for undiluted human serum) and microorganisms. The pCD‐grad‐pV4D4 films, coupled with the stress‐dissipative gradient interface, are highly stretchable up to 50% without compromising the fouling‐resistance. The fouling‐resistance is maintained after 1 day of sonication, 10 days of water flushing, and 30 days of water shearing. Further, the pCD‐grad‐pV4D4 films are fully transparent and patternable, making them a prospective alternative for future non‐fouling biomedical applications.

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Molecular level studies on interfacial hydration of zwitterionic and other antifouling polymers in situ

Cited by 161 publications

References 82 publications

Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Controlled degradation of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) hydrogels

Synthesis of a Stretchable Polyampholyte Hydrophilic Film with Compositional Gradient for Long‐Term Stable, Substrate‐Independent Fouling‐Resistant Coating

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