2011
DOI: 10.1590/s0103-50532011001200002
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Molecular interactions of mefenamic acid with lipid bilayers and red blood cells

Abstract: O ácido mefenâmico é um anti-inflamatório não esteroidal (NSAID), também prescrito no tratamento da dor. No presente trabalho, os efeitos estruturais na membrana de eritrócitos humanos e de modelos moleculares foram investigados. Esta última foi composta em bicamadas construídas de dimiristoilfosfatidilcolina (DMPC) e dimiristoilfosfatidiletanolamina (DMPE), classes de lipídios encontrados nas porções interna e externa do eritrócito e da maioria das membranas celulares, respectivamente. Este artigo apresenta e… Show more

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Cited by 12 publications
(2 citation statements)
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“…For instance, the fatty acid composition and the membrane fluidity of the erythrocytes of hypertensive patients was found to be disturbed in comparison with normotensive subjects [ 14 , 15 ]. Simultaneously, various NSAIDs were found to induce morphologic changes in red blood cells, including mefenamic acid, diclofenac, ibuprofen, naproxen, and aspirin [ 16 , 17 , 18 , 19 , 20 ]. In this sense, it is conceivable that NSAIDs-induced changes in biological membranes are an additional mechanism underlying the cardiotoxicity of these drugs.…”
Section: Introductionmentioning
confidence: 99%
“…For instance, the fatty acid composition and the membrane fluidity of the erythrocytes of hypertensive patients was found to be disturbed in comparison with normotensive subjects [ 14 , 15 ]. Simultaneously, various NSAIDs were found to induce morphologic changes in red blood cells, including mefenamic acid, diclofenac, ibuprofen, naproxen, and aspirin [ 16 , 17 , 18 , 19 , 20 ]. In this sense, it is conceivable that NSAIDs-induced changes in biological membranes are an additional mechanism underlying the cardiotoxicity of these drugs.…”
Section: Introductionmentioning
confidence: 99%
“…It has been suggested that NSAIDs should be tested in combination with chemotherapy and radiotherapy to potentiate the anti-tumor effect. Although most of the biological activities of NSAIDs are related with COX-dependent mechanisms, several studies have demonstrated that NSAIDs interact with membrane phospholipids in a COXindependent path that could be involved in their biological activity [16][17][18][19][20][21][22][23][24][25].…”
Section: Introductionmentioning
confidence: 99%