2016
DOI: 10.1016/j.bbamem.2016.06.009
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Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) represent an effective pain treatment option and therefore one of the most sold therapeutic agents worldwide. The study of the molecular interactions responsible for their physiological activity, but also for their side effects, is therefore important. This report presents data on the interaction of the most consumed NSAIDs (ibuprofen, naproxen and diclofenac) with one main phospholipid in eukaryotic cells, dimyristoylphosphatidylserine (DMPS). The applied techniq… Show more

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Cited by 58 publications
(45 citation statements)
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References 62 publications
(71 reference statements)
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“…In some cases, almost 95% removal of ibuprofen has been achieved by conventional wastewater treatment but production of by-products such as hydroxyl-IBP and carboxy-IBP is major problem which sometimes proves to be more toxic than IBP (Smook, Zho, & Zytner, 2008). The photoproducts are reported to cause phototoxic effects due to their photosensitizing properties (Manrique-Moreno, Heinbockel, Suwalsky, Garidel, & Brandenburg, 2016). Physical, chemical, or biological wastewater treatment methods are deemed less effective for complete elimination of highly persistent chemicals, thus necessitating the research on advanced oxidation processes (AOPs) (Krishnan, Rewindran, Sinnath, & Lim, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…In some cases, almost 95% removal of ibuprofen has been achieved by conventional wastewater treatment but production of by-products such as hydroxyl-IBP and carboxy-IBP is major problem which sometimes proves to be more toxic than IBP (Smook, Zho, & Zytner, 2008). The photoproducts are reported to cause phototoxic effects due to their photosensitizing properties (Manrique-Moreno, Heinbockel, Suwalsky, Garidel, & Brandenburg, 2016). Physical, chemical, or biological wastewater treatment methods are deemed less effective for complete elimination of highly persistent chemicals, thus necessitating the research on advanced oxidation processes (AOPs) (Krishnan, Rewindran, Sinnath, & Lim, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Non-steroidal anti-inflammatory drugs (NSAIDs) are potent synthetic drugs, widely used for the treatment of inflammatory diseases. Unfortunately, currently available NSAIDs have not been completely successful in clinical applications because of their serious side effects, such as gastric lesions, renal damage, bronchospasm, and cardiac abnormalities [ 20 ]. Therefore, there is a global search for new anti-inflammatory drugs as alternatives to NSAIDs.…”
Section: Introductionmentioning
confidence: 99%
“…Ibuprofen, 2‐(4‐isobutylphenyl)propionic acid, a non‐steroidal anti‐inflammatory analgesic, is commonly used as an antipyretic and anti‐rheumatic . As a pharmaceutical intermediate for ibuprofen synthesis, unsurprisingly, α‐phenylethanol (PE) has attracted wide attention.…”
Section: Introductionmentioning
confidence: 99%