Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes

Manrique-Moreno, Marcela; Heinbockel, Lena; Suwalsky, Mario; Garidel, Patrick; Brandenburg, Klaus

doi:10.1016/j.bbamem.2016.06.009

Cited by 51 publications

(36 citation statements)

References 62 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In some cases, almost 95% removal of ibuprofen has been achieved by conventional wastewater treatment but production of by-products such as hydroxyl-IBP and carboxy-IBP is major problem which sometimes proves to be more toxic than IBP (Smook, Zho, & Zytner, 2008). The photoproducts are reported to cause phototoxic effects due to their photosensitizing properties (Manrique-Moreno, Heinbockel, Suwalsky, Garidel, & Brandenburg, 2016). Physical, chemical, or biological wastewater treatment methods are deemed less effective for complete elimination of highly persistent chemicals, thus necessitating the research on advanced oxidation processes (AOPs) (Krishnan, Rewindran, Sinnath, & Lim, 2016).…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic degradation of ibuprofen in water using TiO₂ and ZnO under artificial UV and solar irradiation

Tanveer

Guyer²,

Abbas

2019

Water Environment Research

View full text Add to dashboard Cite

The degradation of anti‐inflammatory and antipyretic drug (Ibuprofen; IBP) has been described in this study by using photocatalytic‐based advanced oxidation processes. The catalysts (TiO2 and ZnO) were activated by irradiation of artificial UV lamp and solar rays for the generation of highly oxidizing species which resulted in the degradation of IBP to intermediates and finally to carbon dioxide and water. In solar reactor, quartz and borosilicate tubes were installed for absorption of required ultraviolet rays and curved chrome plates were used to reflect and concentrate rays on the tubes containing feed mixture. The liquid chromatography, Total organic carbon (TOC), and Chemical oxygen demand (COD) tests were employed to determine the degradation rates and demineralization of solution samples. At catalyst dosing of 1–1.5 g/L, TiO2‐based experiments showed high degradation rate under acidic conditions. Similarly, for ZnO catalyst, 1 g/L dozing rate was found to be effective under neutral conditions (pH = 7.0). UV lamp‐based photocatalysis had higher degradation rate as compared to that of solar reactor. Moreover, better absorption of solar rays by quartz tubes resulted in higher degradation than that in borosilicate tubes. For UV lamp photocatalysis, the TOC and COD reduction was higher. With improved catalyst doping and better solar reactor design, solar‐based IBP degradation could be more promising than UV‐based catalysis. Practitioner points TiO2 and ZnO were employed to generate oxidizing agents for comparative photocatalytic degradation. Degradation rate of Ibuprofen with TiO2 was much higher compared to ZnO. Quartz material was found more effective as radiation absorbing material than borosilicate glass for solar photo catalysis. Influence of catalyst loading (TiO2 and ZnO) and pH conditions on degradation rate and mineralization of IBP was examined. IBP is a carcinogenic and endocrine disrupting drug so its degradation in water can protect ecological and human life.

show abstract

Section: Introductionmentioning

confidence: 99%

Photocatalytic degradation of ibuprofen in water using TiO₂ and ZnO under artificial UV and solar irradiation

Tanveer

Guyer²,

Abbas

2019

Water Environment Research

View full text Add to dashboard Cite

show abstract

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are potent synthetic drugs, widely used for the treatment of inflammatory diseases. Unfortunately, currently available NSAIDs have not been completely successful in clinical applications because of their serious side effects, such as gastric lesions, renal damage, bronchospasm, and cardiac abnormalities [ 20 ]. Therefore, there is a global search for new anti-inflammatory drugs as alternatives to NSAIDs.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling

Kim¹,

Kim²,

Choi³

et al. 2018

Nutrients

View full text Add to dashboard Cite

The fruit of Stauntonia hexaphylla is commonly used as a traditional anthelmintic in Korea, Japan, and China. However, its anti-inflammatory activity and the underlying mechanisms have not been studied systematically. In the present study, we examined the anti-inflammatory activities of an aqueous extract of S. hexaphylla fruit (SHF) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. The SHF extract contained anti-inflammatory compounds, such as neochlorogenic acid, chlorogenic acid, and cryptochlorogenic acid. The extract inhibited protein levels of inducible nitric oxide synthase and the activity of cyclooxygenase enzyme, with concomitant reductions in the production of nitric oxide and prostaglandin E2 in LPS-activated RAW 264.7 cells. Additionally, the SHF extract reduced the production of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. The SHF extract attenuated LPS-induced nuclear factor-κB (NF-κB) activation by decreasing the phosphorylation of its inhibitor, IκBα. Furthermore, the SHF extract showed a significant anti-inflammatory effect in vivo by reducing the volume of carrageenan-induced paw edema in rats. Our results suggest that the SHF extract exerts potential anti-inflammatory properties against LPS-activated RAW 254.7 cells, and in an animal model of inflammation.

show abstract

“…Ibuprofen, 2‐(4‐isobutylphenyl)propionic acid, a non‐steroidal anti‐inflammatory analgesic, is commonly used as an antipyretic and anti‐rheumatic . As a pharmaceutical intermediate for ibuprofen synthesis, unsurprisingly, α‐phenylethanol (PE) has attracted wide attention.…”

Section: Introductionmentioning

confidence: 99%

Highly selective hydrogenation of acetophenone over supported amorphous alloy catalyst

Wang

Zhang

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

Alpha‐phenylethanol (PE) is an essential chemical in the field of medicine and synthetic perfumery. Therefore, in this work, we used a supported Ni–B–P amorphous alloy catalyst (Ni–B–P/SiO2) in the hydrogenation of acetophenone (AP) to α‐PE, which demonstrated excellent catalytic activity and selectivity, compared with Ni–B/SiO2 (KBH4 reduction of nickel salt). Ni–B–P/SiO2 exhibited a high AP hydrogenation conversion of approximately 99%, whereas the PE selectivity reached up to 94%, which is approximately 1.4‐fold higher than that of Ni–B/SiO2 (about 69%), thereby directly proving the unique inhibition of AP hydrogenation over hydrogenation of P in the Ni–B catalytic system. The doped P in Ni–B–P/SiO2 enhances the oxidation resistance and maintains the valence stability of Ni and B. Furthermore, sufficient experimental data were collected to determine the kinetic parameters. Based on the Langmuir–Hinshelwood model, we assumed that (i) AP and H2 compete for adsorption on Ni–B–P/SiO2; (ii) AP has strong adsorptive capacity on Ni–B–P/SiO2; and (iii) PE coverage on the catalyst was negligible. Then, the dynamic equation was derived, which indicated that experimental data agree well with the dynamic model. Finally, the activation energy was confirmed to be 50.73 KJ/mol. This report will open up an avenue for the industrialization of amorphous alloy catalysts.

show abstract

Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes

Cited by 51 publications

References 62 publications

Photocatalytic degradation of ibuprofen in water using TiO₂ and ZnO under artificial UV and solar irradiation

Photocatalytic degradation of ibuprofen in water using TiO₂ and ZnO under artificial UV and solar irradiation

Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling

Highly selective hydrogenation of acetophenone over supported amorphous alloy catalyst

Contact Info

Product

Resources

About

Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes

Cited by 51 publications

References 62 publications

Photocatalytic degradation of ibuprofen in water using TiO2 and ZnO under artificial UV and solar irradiation

Photocatalytic degradation of ibuprofen in water using TiO2 and ZnO under artificial UV and solar irradiation

Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling

Highly selective hydrogenation of acetophenone over supported amorphous alloy catalyst

Contact Info

Product

Resources

About

Photocatalytic degradation of ibuprofen in water using TiO₂ and ZnO under artificial UV and solar irradiation

Photocatalytic degradation of ibuprofen in water using TiO₂ and ZnO under artificial UV and solar irradiation