Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias

Fernandes, Tania Aparecida Rodrigues; Fukai, Regina; Souza, Cármino Antonio De; Lorand-Metze, Irene; Magna, Luís Alberto; Kraemer, Maria Helena Stangler

doi:10.1016/j.bcmd.2009.10.006

Cited by 16 publications

(9 citation statements)

References 25 publications

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“…[9] It is important to study the HLA genes and acute leukemia as these genes may have positive or negative associations in the development of leukemia. [17] In our study, no positive association was observed between HLA alleles and ALL using the PCR-SSOP technique, which is matching with that reported by Villalobos et al who worked with the PCR-sequence-specific primer and sequence-specific oligonucleotide techniques on Venezuelan population. [18] In the present study, no increased frequency of any individual HLA-A, HLA-DRB1, and HLA-DQB1 antigen was observed in patients with acute leukemia, AML, or in ALL compared with controls, but the frequency of HLA-A*11 and HLA-DRB1*11 was lower in ALL and in acute leukemia as compared with the controls, suggesting their negative association with the disease.…”

Section: Discussionsupporting

confidence: 92%

Human leukocyte antigen associations with acute leukemia: An indian perspective

Solanki

Mishra

Tiwari

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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Objective: Acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML) are neoplastic blood disorders in which the cancerous white blood cells accumulate, resulting in a significant morbidity and mortality. Human leukocyte antigen (HLA) association is observed as one of the factors in the development of leukemia. The objective of the present study was to analyze the allele frequency of HLA Class I (HLA-A, HLA-B, and HLA-C) and Class II (HLA-DRB1 and HLA-DQB1) in Indian acute leukemia patients and to compare them with the frequencies in healthy, unrelated Indian individuals. Materials and Methods: We included 500 Indian leukemic patients (AML = 324 and ALL = 176) and 1000 unrelated, healthy, Indian individuals as controls. The HLA typing was performed using polymerase chain reaction with sequence-specific oligonucleotide probes. Results: On univariate analysis, allele frequencies of HLA-AFN*0111 and HLA-DRB1FN*0111 were lower in patients with ALL ( P = 0.0181 and P = 0.0025, respectively). Whereas of HLA-AFN*0111, HLA-DRB1FN*0111, and HLA-BFN*0151, these frequencies were relatively lower in patients with acute leukemia (AML + ALL) ( P = 0.0382, P = 0.0093 and P = 0.0384, respectively) and HLA-CFNx0101 ( P = 0.0304) in AML when compared with control individuals. In contrast, the HLA-BFN*0139 and HLA-CFN*0107 allele frequency was higher in acute leukemia ( P = 0.00372 and P = 0.0463, respectively) and in AML ( P = 0.0010 and P = 0.0178, respectively) than that in controls. On multivariate analysis, BFNx0139 showed positive associations with acute leukemia ( P = 0.006) and AML ( P = 0.002). HLA-AFN*0111 and-DRB1FN*0111 showed a negative association with acute leukemia ( P = 0.009 and P < 0.0001, respectively) and ALL ( P = 0.013 and P < 0.0001, respectively). Conclusions: The HLA-BFN*0139 has a positive association with AML and acute leukemia, whereas HLA-AFN*0111 and HLA-DRB1FN*0111 alleles have negative association with ALL and HLA-BFN*0151 along with these two alleles with acute leukemia. No positive association was observed with ALL. HLA-CFN*0101 frequency was lower in AML patients than that in controls.

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Section: Discussionsupporting

confidence: 92%

Human leukocyte antigen associations with acute leukemia: An indian perspective

Solanki

Mishra

Tiwari

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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“…For example, the frequency of A*03, B*13, B*40, and DRB1*03 was inconsistent with the results of other reported Turkish studies [11,12]. In the literature, some HLA haplotypes have also been accepted as important risk factors for developing leukemia [10,19]. For example, a negative association with the A*02/B*35/DRB1*13 haplotype was observed in patients with ALL [12].…”

Section: Discussionmentioning

confidence: 99%

The Frequency of HLA-A, HLA-B, and HLA-DRB1 Alleles in Patients with Acute Lymphoblastic Leukemia in the Turkish Population: A Case-Control Study

Patıroğlu¹,

Akar²

2016

Tjh

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We studied the frequencies of human leukocyte antigen alleles (A, B, and DRB1) in 90 patients with acute lymphoblastic leukemia (ALL) and then compared them with 126 controls in this study. Although the frequencies of the A*03 allele, the DRB1*03 allele, the DRB1*04 allele, the A*02/B*35/DRB1*13 haplotype, and homozygosity of A*02 were higher in patients (p=0.006, p=0.003, p=0.002, p=0.01, and p=0.02, respectively), the frequencies of the A*23, B*13, B*40, and DRB1*13 alleles were lower (p=0.002, p=0.07, p=0.002, and p=0.003, respectively) in patients than controls. The frequencies of the DRB1*04 and DRB1*07 alleles were higher in patients in the high-risk group and standard-risk group, respectively (p=0.009 and p=0.007, respectively). This study indicated that the frequency of the A*03 allele, the DRB1*03 allele, the DRB1*04 allele, the A*02/B*35/DRB1*13 haplotype, and A*02 homozygosity may play a predisposing role in patients with ALL in the Turkish population. The frequency of the DRB1*04 and DRB1*07 alleles may also be associated with high risk and standard risk in patients with ALL, respectively.

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“…Studies of the correlation between HLA polymorphisms and susceptibility and resistance to disease began soon after serological techniques for HLA class I typing were standardized. The biological importance of associations between HLA haplotypes and acute leukaemia is emphasized by the fact that HLA may be involved in disease susceptibility or 31 The first study on HLA in human leukaemia demonstrated an increased frequency of HLA-A2 in ALL in 1967. 32 The frequency of any individual HLA-A and HLA-B antigen was not significantly higher in patients with ALL compared with controls in the present study, although HLA-A23 and HLA-B7 antigens occurred significantly less frequently in these patients than in controls.…”

Section: Discussionmentioning

confidence: 99%

The Frequency of HLA Class I and II Alleles in Turkish Childhood Acute Leukaemia Patients

et al. 2010

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In this study, blood samples were taken from 200 patients with childhood acute leukaemias, including acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML), and from 100 healthy volunteers (controls). The frequency of the human leucocyte antigen (HLA)-DRB1*04 allele was significantly higher, and the frequencies of the HLA-A23 and HLA-B7 antigens were significantly lower, in patients with ALL compared with controls. Among patients with AML, the frequency of the HLA-B49 antigen and the HLA-DRB1*15 allele were significantly higher, whereas the frequencies of the HLA-A11 and HLA-B38 antigens were significantly lower compared with controls. The frequency of the HLA-DRB1*04 allele was also significantly higher in male patients with ALL and AML, whereas the HLA-DRB1*13 allele was found significantly less frequently in male AML and female ALL patients than in controls. To date, this is the only study to evaluate the associations between HLA molecules and leukaemia in a Turkish population with acute childhood leukaemia.

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Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias

Cited by 16 publications

References 25 publications

Human leukocyte antigen associations with acute leukemia: An indian perspective

Human leukocyte antigen associations with acute leukemia: An indian perspective

The Frequency of HLA-A, HLA-B, and HLA-DRB1 Alleles in Patients with Acute Lymphoblastic Leukemia in the Turkish Population: A Case-Control Study

The Frequency of HLA Class I and II Alleles in Turkish Childhood Acute Leukaemia Patients

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