The Frequency of HLA Class I and II Alleles in Turkish Childhood Acute Leukaemia Patients

Özdilli, Kürşat; Oğuz, Fatma; Anak, S.; Kekik, Çiğdem; Çarin, Mahmut; Gedikoğlu, Gündüz

doi:10.1177/147323001003800531

Cited by 24 publications

(26 citation statements)

References 28 publications

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“…This similarity for the DRB1*13 allele among studies may be explained by geographic proximity and interactions between Iranian [10] and Turkish populations [12]. In another Turkish study, the frequency of DRB1*04 was reported to be higher and the frequency of A*23 was reported to be lower in patients with ALL, as in our study [11]. In that study, inconsistent with our data, B*07 frequency was observed to be lower in patients with ALL.…”

Section: Discussionsupporting

confidence: 82%

“…The HLA genes are the most polymorphic genes in the human genome [7]. An association between ALL and HLA alleles has been shown in the literature; however, the data are not conclusive so far [8,9,10,11,12,13]. There are no identified consistent leukemia-associated HLA class I genes to date, but investigations of HLA class II genes such as DRB3, DRB4, and DRB5 have demonstrated consistent associations in patients with leukemia [14].…”

Section: Introductionmentioning

confidence: 99%

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The Frequency of HLA-A, HLA-B, and HLA-DRB1 Alleles in Patients with Acute Lymphoblastic Leukemia in the Turkish Population: A Case-Control Study

Patıroğlu¹,

Akar²

2016

Tjh

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We studied the frequencies of human leukocyte antigen alleles (A, B, and DRB1) in 90 patients with acute lymphoblastic leukemia (ALL) and then compared them with 126 controls in this study. Although the frequencies of the A*03 allele, the DRB1*03 allele, the DRB1*04 allele, the A*02/B*35/DRB1*13 haplotype, and homozygosity of A*02 were higher in patients (p=0.006, p=0.003, p=0.002, p=0.01, and p=0.02, respectively), the frequencies of the A*23, B*13, B*40, and DRB1*13 alleles were lower (p=0.002, p=0.07, p=0.002, and p=0.003, respectively) in patients than controls. The frequencies of the DRB1*04 and DRB1*07 alleles were higher in patients in the high-risk group and standard-risk group, respectively (p=0.009 and p=0.007, respectively). This study indicated that the frequency of the A*03 allele, the DRB1*03 allele, the DRB1*04 allele, the A*02/B*35/DRB1*13 haplotype, and A*02 homozygosity may play a predisposing role in patients with ALL in the Turkish population. The frequency of the DRB1*04 and DRB1*07 alleles may also be associated with high risk and standard risk in patients with ALL, respectively.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

The Frequency of HLA-A, HLA-B, and HLA-DRB1 Alleles in Patients with Acute Lymphoblastic Leukemia in the Turkish Population: A Case-Control Study

Patıroğlu¹,

Akar²

2016

Tjh

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“…In addition, a significantly lower frequency of the HLA-DRB1*13 allele was observed among female patients compared to female controls (4).…”

Section: Discussionmentioning

confidence: 80%

“…A significant increase in the frequency of the HLA-DRB1*04 allele in the overall and male ALL patients was reported in a Turkish study (4). In addition, a significantly lower frequency of the HLA-DRB1*13 allele was observed among female patients compared to female controls (4).…”

Section: Discussionmentioning

confidence: 87%

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Human leukocyte antigen-DRB1 polymorphism in childhood acute lymphoblastic leukemia

Ansary

Mohammed

Hassan

et al. 2014

Molecular and Clinical Oncology

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Abstract. Similar to autoimmune diseases, there are clear associations between resistance or susceptibility to cancer and the classic human leukocyte antigen (HLA) profile of an individual. HLA-associated susceptibility to childhood acute lymphoblastic leukemia (ALL) may provide clues to leukemogenesis in general and to the role of other risk factors. The present study aimed to determine the association between the HLA-DRB1 genotype and susceptibility to ALL in children and to assess the prognostic value of HLA-DRB1 alleles in these patients. This study included 50 ALL patients who were consecutively admitted to the Pediatric Oncology Unit of Zagazig University Hospital and 50 gender-matched healthy volunteers as a control group. The patients were subjected to full clinical history, thorough clinical examination and routine laboratory investigations. Molecular HLA-DRB1 typing for patients and controls using the reverse sequence-specific oligonucleotide probe technique was performed. HLA-DRB1*04 allele frequency was significantly higher in female patients compared to that in female controls (P=0.03) and in patients aged <10 years compared to those aged ≥10 years at the time of diagnosis (P= 0.01). HLA-DRB1*11 allele frequency was significantly higher in high-risk compared to standard-risk patients (P= 0.01) and in refractory patients compared to those who achieved remission (P= 0.02). In conclusion, the HLA-DRB1*04 allele appears to be a female-specific susceptibility factor for the acquisition of childhood ALL and it may affect the age of onset of ALL. In addition, the HLA-DRB1*11 allele may be of prognostic significance in childhood ALL. However, further larger studies are required to support the conclusions drawn from this study. IntroductionAcute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing one quarter of all pediatric cancers worldwide (1).Over 40 years since the first associations between particular human leukocyte antigen (HLA) profiles and disease susceptibility were described, the identification of large numbers of HLA-associated diseases parallels our improved understanding of the genetic complexity of the HLA system and its extensive polymorphism. These associations involve malignant as well as autoimmune diseases, including the well-known association between HLA-B27 and ankylosing spondylitis. Over time, several hundred diseases have been reported to occur more frequently in individuals with particular HLA genotypes (2). These diseases include a broad spectrum of immune-mediated diseases involving all major organ systems, certain malignancies, infectious diseases and, more recently, adverse reactions to particular drugs (2).One of the factors that may determine whether a child develops ALL is how it responds to the candidate infection. Since immune responses to infection are under the partial control of HLA genes, an association between an HLA allele and ALL may provide support for an infectious etiology (3).The biological significance of the associati...

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The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia

Kerr

Mattey

2015

Rev. Med. Virol.

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In this article, we review the evidence suggesting a possible role for B19 virus in the pathogenesis of a subset of cases of acute leukemia. Human parvovirus B19 infection may complicate the clinical course of patients with acute leukemia, and may also precede the development of acute leukemia by up to 180 days. Parvovirus B19 targets erythroblasts in the bone marrow, and may cause aplastic crisis in patients with shortened red cell survival. Aplastic crisis represents a prodrome of ALL in 2% patients. There is significant overlap between those HLA class I and II alleles which are associated with a vigorous immune response and development of symptoms during B19 infection, and those HLA alleles which predispose to development of acute leukemia. Acute symptomatic B19 infection is associated with low level of circulating IL-10 consistent with a vigorous immune response; deficient IL-10 production at birth was recently found to be associated with subsequent development of acute leukemia. Anti-B19 IgG has been associated with a particular profile of methylation of human cancer genes in patients with acute leukemia, suggesting an additional hit and run mechanism. The proposed role for parvovirus B19 in the pathogenesis of acute leukemia fits very well with the delayed infection hypothesis and with the 2-step mutation model, which describes the carriage of the first mutation prior to birth, followed by suppression of haematopoiesis, which allows rapid proliferation of cells harbouring the first mutation, acquisition of a second activating mutation, and expansion of cells carrying both mutations, resulting in a clinical presentation of acute leukemia.

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The Frequency of HLA Class I and II Alleles in Turkish Childhood Acute Leukaemia Patients

Cited by 24 publications

References 28 publications

The Frequency of HLA-A, HLA-B, and HLA-DRB1 Alleles in Patients with Acute Lymphoblastic Leukemia in the Turkish Population: A Case-Control Study

The Frequency of HLA-A, HLA-B, and HLA-DRB1 Alleles in Patients with Acute Lymphoblastic Leukemia in the Turkish Population: A Case-Control Study

Human leukocyte antigen-DRB1 polymorphism in childhood acute lymphoblastic leukemia

The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia

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