Molecular characteristics and anti-inflammatory activity of the fucoidan extracted from Ecklonia cava

Lee, Seung‐Hong; Ko, Chang-Ik; Ahn, Ginnae; You, SangGuan; Kim, Jin-Soo; Heu, Min Soo; Kim, Jaeil; Jee, Youngheun; Jeon, You‐Jin

doi:10.1016/j.carbpol.2012.03.056

Cited by 130 publications

(69 citation statements)

References 31 publications

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“…On the other hand, fucoidans were reported to influence pro-inflammatory signalling molecules and pathways in macrophages, such as p38, Erk, JNK [34], HMGB1 and NF-κB [45]. These signalling pathways are essential for macrophages to become a major source of other pro-inflammatory cytokines and consistent with this previously described in vitro activity of fucoidans [46], we observed a marked reduction of most measured cytokines that originate from inflamed colon tissues.…”

Section: Discussionsupporting

confidence: 90%

Fucoidan Extracts Ameliorate Acute Colitis

Lean

Eri

Fitton³

et al. 2015

PLoS ONE

101

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Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn’s disease, are an important cause of morbidity and impact significantly on quality of life. Overall, current treatments do not sustain a long-term clinical remission and are associated with adverse effects, which highlight the need for new treatment options. Fucoidans are complex sulphated, fucose-rich polysaccharides, found in edible brown algae and are described as having multiple bioactivities including potent anti-inflammatory effects. Therefore, the therapeutic potential of two different fucoidan preparations, fucoidan-polyphenol complex (Maritech Synergy) and depyrogenated fucoidan (DPF) was evaluated in the dextran sulphate sodium (DSS) mouse model of acute colitis. Mice were treated once daily over 7 days with fucoidans via oral (Synergy or DPF) or intraperitoneal administration (DPF). Signs and severity of colitis were monitored daily before colons and spleens were collected for macroscopic evaluation, cytokine measurements and histology. Orally administered Synergy and DPF, but not intraperitoneal DPF treatment, significantly ameliorated symptoms of colitis based on retention of body weight, as well as reduced diarrhoea and faecal blood loss, compared to the untreated colitis group. Colon and spleen weight in mice treated with oral fucoidan was also significantly lower, indicating reduced inflammation and oedema. Histological examination of untreated colitis mice confirmed a massive loss of crypt architecture and goblet cells, infiltration of immune cells and oedema, while all aspects of this pathology were alleviated by oral fucoidan. Importantly, in this model, the macroscopic changes induced by oral fucoidan correlated significantly with substantially decreased production of at least 15 pro-inflammatory cytokines by the colon tissue. Overall, oral fucoidan preparations significantly reduce the inflammatory pathology associated with DSS-induced colitis and could therefore represent a novel nutraceutical option for the management of IBD.

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Section: Discussionsupporting

confidence: 90%

Fucoidan Extracts Ameliorate Acute Colitis

Lean

Eri

Fitton³

et al. 2015

PLoS ONE

101

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“…This indicated accelerated wound healing via the anti-inflammatory activities of LMF or promotion of the granulation phase, in agreements of another study [14]. Fucoidans mediate anti-inflammatory effects via reduction of neutrophil adhesion and leukocyte recruitment, or inhibition of proinflammatory cytokines release [19,37]. This might be an intrinsic property of fucoidans, since fucoidans obtained from nine species of brown algae showed similar effects, regardless of their fucose and sulfate contents or other structural features of their polysaccharide backbones [37].…”

Section: Discussionsupporting

confidence: 65%

“…They have received significant biotechnological research interest because of their antitumor [14], immunomodulatory [15], antioxidant [16], antivirus [17], anticoagulant [18] and anti-inflammatory [19] effects as well as for being an abundant non-animal origin and non-toxic edible resource [16]. Fucoidans possibly interact with a variety of growth factors such as basic fibroblast growth factor (bFGF) [20] and transforming growth factor-β [21], through mechanisms similar to that of heparin binding, to mediate these beneficial effects.…”

Section: Introductionmentioning

confidence: 99%

Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model

et al. 2017

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Low molecular weight fucoidan (LMF) has been reported to possess anti-inflammatory and antioxidant activities. Thus, we examined the effects of LMF extracted from Undaria pinnatifida on dermal wounds. Five round dermal wounds were created on the dorsal back of rats, and they were then treated topically with distilled water (DW), Madecasol Care™ (MC) or LMF at 200, 100 and 50 mg/mL, twice a day for a week. There were dose-dependent increases in wound contraction in the groups receiving LMF but not in the MC group, compared with the DW. Histopathological examination revealed that LMF treatment accelerated wound healing, which was supported by increases in granular tissue formation on day four post-treatment but a decrease on day seven, accompanied by an evident reduction in inflammatory cells. In the LMF-treated wounds, collagen distribution and angiogenesis were increased in the granular tissue on days four and seven post-treatment. Immunoreactive cells for transforming growth factor-β1, vascular endothelial growth factor receptor-2 or matrix metalloproteinases 9 were also increased, probably due to tissue remodeling. Furthermore, LMF treatment reduced lipid peroxidation and increased antioxidant activities. These suggested that LMF promotes dermal wound healing via complex and coordinated antioxidant, anti-inflammatory and growth factor-dependent activities.

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“…Reducing NO level by inhibiting iNOS expression has been used to assess the effect of agents on the anti-inflammatory process (Hwang, Kim, Park, Lee, & Kim, 2014;Kim et al, 2014;Lee et al, 2014). Lee et al (2012) demonstrated that fucoidans from Ecklonia cava inhibit NO production in LPS-induced Raw264.7 cells by downregulating iNOS expression. As shown in Fig.…”

Section: Effect Of Scp On Inos Expression and Mapk And Nf-kb Activationmentioning

confidence: 99%

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

et al. 2016

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Molecular characteristics and anti-inflammatory activity of the fucoidan extracted from Ecklonia cava

Cited by 130 publications

References 31 publications

Fucoidan Extracts Ameliorate Acute Colitis

Fucoidan Extracts Ameliorate Acute Colitis

Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

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