Molecular and cellular basis of pathogenesis of tick-borne encephalitis

Although studies have established that immune mechanisms are important in controlling tick-borne encephalitis virus (TBEV) infection, the interactions of different TBEV strains with cells of innate and adaptive immunity are not well understood. In this study, the ability of two Far Eastern subtype TBEV strains (Dal'negorsk and Primorye-183) with various degrees of pathogenicity for humans to modulate the expression of membrane molecules differently on human immune cells were investigated using a whole-blood flow cytometry-based assay. The whole-blood samples (from 10 healthy donors) were infected with TBEV strains and analyzed for the virus binding to the blood cells, as well as expression of adhesion (CD11b and ICAM-1) and activation (CD69, CD25, CD95) molecules on the surfaces of monocytes, granulocytes, natural killer (NK) cells, and T-lymphocytes (CD4+, CD8+) at selected times (3, 6, and 24 h post-infection). It was found that the highly pathogenic Dal'negorsk strain penetrated rapidly and was actively replicated in the blood cells, inducing downregulation of CD11b, ICAM-1, and CD69 on monocytes and a significant decrease of NK cells expressing CD69, CD25, CD95, and CD8 T-lymphocytes expressing CD69 compared with the mock-infected cells. The nonpathogenic Primorye-183 strain penetrated slowly and was replicated in the blood cells, but caused a significant increase in the adhesion and activation of molecule expression to trigger innate defense mechanisms and enable the rapid elimination of the virus from the organism. Thus, TBEV-induced activation or suppression of adhesion and activation receptors expression form an essential part of fundamental virus properties, that is, virulence and pathogenicity.

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Molecular Mechanisms of Interaction Between Human Immune Cells and Far Eastern Tick-Borne Encephalitis Virus Strains

Крылова

Smolina

Леонова

2015

Viral Immunology

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Molecular medicine and viral infections: modern view on the problemand strategy of interrelations

Ryazantseva¹

2008

Bûll. sib. med.

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The lecture presents basic directions of molecular medicine development. Special attention is devoted to prior direction of identification of molecular and genetic markers of predisposition to chronic course of socially important viral infections, development of molecular basis for personalized therapy and outcome prognosis of interrelations between an infect and a human. Analysis of literature data concerning the discussed prob lem and also the results of proper investigations are presented.

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Changing of cytokine status in acute period of tick-borne neuroinfections in children

Bedareva¹,

Попонникова²,

Galiyeva³

et al. 2009

Bûll. sib. med.

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Activity of cytokines of tick-borne infection of children was researched. Revealed low level of interferon-γ concentration testify about abnormality of cellular link immune protection and typical for focal forms of tick-borne encephalitis. Severe forms of disease run with background increase of interleukin-6 and interleukin10. Maximum increase of tumor necrosis factor-α was detected in cases of mixed-infections. Borreliosis infection flows with background domination of Th-2 over Th-1 type of immune response.

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Molecular and cellular basis of pathogenesis of tick-borne encephalitis

Cited by 3 publications

References 14 publications

Molecular Mechanisms of Interaction Between Human Immune Cells and Far Eastern Tick-Borne Encephalitis Virus Strains

Molecular Mechanisms of Interaction Between Human Immune Cells and Far Eastern Tick-Borne Encephalitis Virus Strains

Molecular medicine and viral infections: modern view on the problemand strategy of interrelations

Changing of cytokine status in acute period of tick-borne neuroinfections in children

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