Activity of cytokines of tick-borne infection of children was researched. Revealed low level of interferon-γ concentration testify about abnormality of cellular link immune protection and typical for focal forms of tick-borne encephalitis. Severe forms of disease run with background increase of interleukin-6 and interleukin10. Maximum increase of tumor necrosis factor-α was detected in cases of mixed-infections. Borreliosis infection flows with background domination of Th-2 over Th-1 type of immune response.
The activity of cytokines and featuries of humoral immunity response in acute period of mixed infection of tick-borne encephalitis and Ixodidae borreliosis in children was researched. The delay of production of antibodies is revealed at meningoencephalitis form. The revealed changes of cytokines status can be used for an estimation of efficiency and correction of spent therapy.
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