Main features of pathogenesis of tick-borne encephalitis virus’ persistense and outcome of the disease are determined by a complex xharacter of interaction between the virus and immune system of a patient. One of the main terms of pathogenetically im- portant virus activation is a low immune resistanse of an organism. The current article discusses role of modification of cellular dif- ferentiation, intercellular cooperation and cytogenetic instability of immunocytes as well as apoptosis as leading features of immu- nopathogenesis of tick-borne encephalitis.
The article presents the results of clinical and epidemiological investigations of morbidity rate of tick-borne encephalitis (TBE) in Tomsk region in a period of 1944—2005. it is shown that Tomsk region is an active natural focus of TBE, leading among other regions of the Russian Federation in morbidity rate and spreading of the infection. Main features of pathomorphosis of clinical ma- nifestitions of TBE were analysed: prevailing of fever and latent forms was determined, as well as decrese of paralytic and menin- geal forms levels.
Up-to-date information on etiology, epidemiology, pathogenesis, clinical manifestation, laboratory and differential diagnosis, treatment and prevention of Ixodes tick-borne borrelioses are given.
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