Molar-Incisor Hypomineralization: Positive Correlation with Atopic Dermatitis and Food Allergies

Hernández, M; Boj, J R; Espasa, E; Planells, Paloma; Peretz, Benjamin

doi:10.17796/1053-4625-42.5.4

Cited by 6 publications

(17 citation statements)

References 33 publications

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“…Therefore, the increase in pro‐inflammatory cytokines may be a risk marker for asthma. There are no studies demonstrating an association between HSPM and asthma, but MIH is associated with respiratory problems in general, including asthma . Hypoxia inherent to asthma inhibits the action of enzymes during the maturation stage and the development of hydroxyapatite crystals .…”

Section: Discussionmentioning

confidence: 99%

“…23 Hypoxia inherent to asthma inhibits the action of enzymes during the maturation stage and the development of hydroxyapatite crystals. 23 It is inferred that the inhibition of these enzymes can be associated with HSPM by interrupting the formation of the mineral content of the tooth. One factor that makes this relationship more worrying is the high prevalence of asthma in children, considered the most common non-communicable disease in this age group.…”

Section: Discussionmentioning

confidence: 99%

“…There are no studies demonstrating an association between HSPM and asthma, but MIH is associated with respiratory problems in general, including asthma . Hypoxia inherent to asthma inhibits the action of enzymes during the maturation stage and the development of hydroxyapatite crystals . It is inferred that the inhibition of these enzymes can be associated with HSPM by interrupting the formation of the mineral content of the tooth.…”

Section: Discussionmentioning

confidence: 99%

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Pre‐term birth and asthma is associated with hypomineralized second primary molars in pre‐schoolers: A population‐based study

Lima

Pereira

Moura

et al. 2019

Int J Paed Dentistry

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Background Hypomineralized second primary molar (HSPM) is a developmental enamel defect that represents a caries‐risk factor. There are few studies about HSPM epidemiology in representative populations. Aim To determine the prevalence and factors associated with HSPM in pre‐schoolers. Design This is a cross‐sectional population‐based study of 5‐year‐old pre‐schoolers from Teresina, Brazil. The sample was randomly selected and stratified by geographic region of the city, type of school (public and private), and sex of the pre‐schoolers (n = 811). Sociodemographic status and pre‐, peri‐, and post‐natal conditions were collected by structured questionnaires. Two calibrated examiners diagnosed HSPM using the criteria of the European Academy of Paediatric Dentistry for molar‐incisor hypomineralization. Severity, colour, location, and extent of lesions were also evaluated. Descriptive analysis of the data and a Poisson regression analysis were performed (P < .05). Results The prevalence of HSPM was 14.9. Demarcated opacities (75.6%) and white/cream colour were the most prevalent (71.4%). Pre‐term pre‐schoolers had 66% (PR = 1.66, 95% CI = 1.07‐2.58), and those who reported asthma in the first year of life had 69% (PR = 1.69, 95% CI = 1.01‐2.85) higher prevalence of HSPM. Conclusions Pre‐term birth and reported asthma in the first year of life were associated with HSPM. The prevalence of HSPM in pre‐schoolers aged 5 years old in Teresina was high.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pre‐term birth and asthma is associated with hypomineralized second primary molars in pre‐schoolers: A population‐based study

Lima

Pereira

Moura

et al. 2019

Int J Paed Dentistry

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“…Presently, we know more about MIH, but its etiology remains unknown. It is supposed to be of systemic origin and although a wide variety of etiological factors have been proposed as mediators in the onset of MIH, a definitive agreement on its etiology has not yet been reached ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…Hernández et al ( 5 ) reported the significant relationship between MIH and the presence of AD and FA, components of the so-called the atopic march, in a study on the etiological factors of MIH. Suspecting that the presence of MIH could be related to allergic march as a whole, the primary rationale for conducting the study was to analyse a sample of children diagnosed with MIH to determine whether or not there was any relationship with the components of allergic march.…”

Section: Introductionmentioning

confidence: 99%

Molar-Incisor Hypomineralisation and Allergic March

Hernández

Mendioroz

2020

Acta Stomatol Croat

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Background Molar-incisor hypomineralisation is a disturbance in dental development that involves first permanent molars as well as permanent incisors with a prevalence that ranges from 2.5% to 40%. Aim The objective of this study was to investigate the effect of atopic diseases on the development of molar-incisor hypomineralisation. Material and methods The study was based on the review of the medical records of a group of 102 children whose age was between eight and 12 years and 11 months and who had previously been diagnosed with MIH. Results An association (χ 2 , p≤0.05) has been found between molar-incisor hypomineralisation in children's mouths and the existence of: atopic dermatitis (OR=2.504; 1.54-4.05 CI 95%), food allergies (OR=2.171; 1.03-4.56 CI 95%), allergic rhinitis (OR=0.17; 0.02-1.27 CI 95%), and asthmatic bronchitis/asthma (OR=1.707; 1.05-2.76 CI 95%). When analyzing the pathologies by location, we found that atopic dermatitis, food allergies, allergic rhinitis and asthma were more frequent in children who had (p≤0.05) #12, #11, #21, #22, #36, #31, #41 and #42 affected. Conclusions The association between molar-incisor hypomineralisation and the presence of atopic diseases in the first 36 months of life underlines the convenience of approaching this problem from a multidisciplinary perspective.

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Association between asthma and enamel defects in primary and young permanent teeth – A systematic review

Rizzardi

Toledo

Ferraz

et al. 2021

Pediatric Pulmonology

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Childhood respiratory diseases, such as asthma, are important public health problems worldwide and could be associated with tooth enamel defects. This study aimed to verify the relationship between asthma and enamel defects in teeth, to answer the following question: "Could asthma in children be significantly associated with enamel defects in deciduous dentition and young permanent teeth?." PUBMED-MEDLINE, EMBASE, LILACS, and COCHRANE databases were systematically searched and assessed articles were cautiously scored according to a predetermined criterion. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses were considered. Twenty-two articles were critically appraised and used as a basis for conclusions. The relationship between asthma and enamel defects was confirmed in the majority of appraised papers, one with a high level of evidence, nine with a moderate level, and four with a low level. Out of the eight manuscripts investigating the influence of asthma medication on enamel defects, only three (one with high, one moderate, and another with a low level of evidence) suggested an association. It can be concluded that asthma is closely connected with enamel defects in young permanent teeth. However, as most of the papers appraised were of cross-sectional or case-control design, further welldesigned clinical investigations with a prospective design are welcome to reinforce our findings.

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Molar-Incisor Hypomineralization: Positive Correlation with Atopic Dermatitis and Food Allergies

Abstract: The present research reveals for the first time a statistically significant relationship between atopic dermatitis and food allergies with the presence of molar-incisor hypomineralization.

Cited by 6 publications

References 33 publications

Pre‐term birth and asthma is associated with hypomineralized second primary molars in pre‐schoolers: A population‐based study

Pre‐term birth and asthma is associated with hypomineralized second primary molars in pre‐schoolers: A population‐based study

Molar-Incisor Hypomineralisation and Allergic March

Association between asthma and enamel defects in primary and young permanent teeth – A systematic review

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