Molar-Incisor Hypomineralisation and Allergic March

Abstract

Background Molar-incisor hypomineralisation is a disturbance in dental development that involves first permanent molars as well as permanent incisors with a prevalence that ranges from 2.5% to 40%. Aim The objective of this study was to investigate the effect of atopic diseases on the development of molar-incisor hypomineralisation. Material and methods The study was based on the review of the medical records of a group of 102 children whose age was between eight and 12 years and 11 months and who had previously been diagnosed with MIH. Results An association (χ 2 , p≤0.05) has been found between molar-incisor hypomineralisation in children's mouths and the existence of: atopic dermatitis (OR=2.504; 1.54-4.05 CI 95%), food allergies (OR=2.171; 1.03-4.56 CI 95%), allergic rhinitis (OR=0.17; 0.02-1.27 CI 95%), and asthmatic bronchitis/asthma (OR=1.707; 1.05-2.76 CI 95%). When analyzing the pathologies by location, we found that atopic dermatitis, food allergies, allergic rhinitis and asthma were more frequent in children who had (p≤0.05) #12, #11, #21, #22, #36, #31, #41 and #42 affected. Conclusions The association between molar-incisor hypomineralisation and the presence of atopic diseases in the first 36 months of life underlines the convenience of approaching this problem from a multidisciplinary perspective.

Association between asthma and enamel defects in primary and young permanent teeth – A systematic review

“…In the northeast urban area of Spain (Barcelona), a cross‐sectional study comprising 705 children, aging from 6 to 14 years verified that MIH was significantly more prevalent among those who had bronchitis/asthma (OR = 5.3, CI: 2.7–10.1, p < 0.001) 28 . The same group of authors with a sample of 102 children (55 boys and 47 girls), whose age was between 8 and 12 years, reinforced the association between MIH and asthmatic bronchitis/asthma (OR: 1.70, CI: 1.05–2.76, p ≤ 0.05) 33 …”

“…1.05-2.76, p ≤ 0.05). 33 Differently from the results described above, lack of association between asthma and enamel defects in children was supported by three manuscripts, most of them rated as the moderate value of evidence. The paper of Ferrazano et al 24…”

“…Regarding research evaluating the relationship between asthma and enamel defects, 82% (14 out of 17) supported the existence of an association (1 scored "grade A," 9 scored "grade B," and 4 scored "grade C" -Table 2) and most of them considered young permanent teeth. 5,18,22,23,[25][26][27][28][29]31,33,37,38 Intriguingly, it is intrauterine that children's first permanent molars/incisors begin the amelogenesis process (from the cusps to the cervical direction of the teeth), which is completed at around 3-5 years of age. 4 Thus, during this period, systemic problems can affect the ameloblasts cells, which are highly sensitive.…”

“…44 Regarding the two studies focusing on enamel defects in primary teeth 32,34 and asthma, divergent findings were found, because one of them pointed to the existence of a significant association, 32 and the other did not 34 (Table 2). Both involved preschool children from the northeast region of Brazil, but the research of Neto et al 34 considered public schools only, 34 and the research of Lima et al 32 Interestingly, in all of the papers that investigated asthma and MIH, a positive relationship was observed 5,[25][26][27][28][29]31,33,37,38 (Table 2).…”

Hipomineralização molar-incisivo (HMI): fatores etiológicos – uma revisão de literatura / Molar incisor hypomineralization (HMI): etiological factors - a literature review

“…Com etiologia ainda indefinida, tem-se buscado evidencias sobre os fatores causadores desta lesão (RESENDE; FAVRETTO, 2019). Em 2001 o HMI foi categorizado como origem sistêmica pela European Academy of Pediatric (FATTURI et al, 2020;HERNANDEZ;MENDIOROZ, 2020). Diversos fatores podem estar associados a sua etiologia, como fatores genéticos, fatores ambientais com prejuízos sistêmicos nos períodos pré, peri e pós natais, durante a primeira infância que corresponde aos primeiros anos de vida, onde o esmalte dentário pode sofrer injurias na sua formação.…”