Moisturizing Effect of Oleogel/Hydrogel Mixtures

Sunflower Oil and Protein-based Novel Bigels as Matrices for Drug Delivery Applications—Characterization andin vitroAntimicrobial Efficiency

“…This will result in the formation of a new category of formulations known as bigels [7][8][9][10] . The main advantage of bigels is its ability to simultaneously deliver both hydrophilic and hydrophobic drugs.…”

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

“…They can also combine all advantages of both drug formulations: (i) the ability to accommodate both hydrophilic and lipophilic drugs; (ii) ensure topical or transdermal drug delivery; (iii) provide controlled drug delivery; and (iv) improve patient compliance [1,2]. Furthermore, Almeida et al [3] demonstrated that bigel formulations have an enhanced moisturizing effect. These properties make them very promising candidates for topical formulations.…”

Development and Physical Characterization of Polymer-Fish Oil Bigel (Hydrogel/Oleogel) System as a Transdermal Drug Delivery Vehicle

“…As oleogels are considered as oily in nature, difficult to remove after application and less patient compliance, therefore bigels were introduced as an alternative gel system that possess the characteristics of both oleogels and aqueous gels, such as cooling effect, increase in hydration of the stratum corneum, good spreadability, and water washable upon application to the skin. In addition, these gels are compatible with many substances, which increases the emollient and moisturizing effect on the skin and improves the penetration of drugs through the skin 11,13 .…”

“…drogels 11 . It is a semi-solid dosage form prepared by intimately mixing two different colloidal species 12 an oleogel and an aqueous gel for topical and transdermal administration of drugs.…”