Sunflower Oil and Protein-based Novel Bigels as Matrices for Drug Delivery Applications—Characterization and<i>in vitro</i>Antimicrobial Efficiency

Behera, Beauty; Sagiri, Sai Sateesh; Pal, Kunal; Pramanik, Krishna; Rana, Usman Ali; Shakir, Imran; Anis, Arfat

doi:10.1080/03602559.2014.974268

Cited by 40 publications

(25 citation statements)

References 55 publications

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“…Lower % of Span in OG1 did not promote emulgel formulation in the bigels (BG1 and BG 2) and hence, their viscosities are higher than the corresponding organogel. Both organogel and bigel formulations demonstrated non-Newtonian pseudoplastic flow and shear thinning behavior similar to that observed with sunflower oil and protein based novel bigels as matrices for drug delivery applications as reported by Behera et al [21].…”

Section: Discussionsupporting

confidence: 79%

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Formulation and in Vitro Characterisation of Soybean Oil-Hpmck4m Based Bigel Matrix for Topical Drug Delivery

Mukherjee¹,

Majee²,

Biswas³

2019

Int J App Pharm

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Objective: Hydrogels with scope for utilization in numerous fields possess limited applications due to problems in incorporating wide range of drugs and crossing the lipophilic barrier of the skin. Attempts to overcome these problems by developing organogel hold drawbacks. Challenges posed by drug lipophilicity or skin permeation can be solved by developing bigel formed via combination of lipophilic and hydrophilic gel phases in a definite proportion. The objective of the present study is to formulate and characterize matrix type bigel of soybean oil and HPMCK4M for topical drug delivery. Methods: Four batches of bigels were developed with two organogel formulations of soybean oil containing 20 and 22% w/v Span 60. Both organogels and bigels were examined for compatibility by FTIR spectroscopy, hemocompatibility and characterized for physical appearance, pH, rheological behavior and in vitro drug release pattern. Results: FTIR study confirmed compatibility between paracetamol and components of organogel or bigel. The oily feel of organogels disappeared with bigels which possessed a creamy and smooth texture. Pseudoplastic behaviour was confirmed by Ostwald-de wale power-law model in both organogels and bigels. Improved drug release was observed in bigel (BG1) formulation containing 3%w/v HPMCK4M and soybean oil based organogel with 20% w/v Span 60 as compared to the corresponding organogel (OG1). Organogels were foundto follow either zero-order kinetics (OG1) or Korsmeyer-Peppasmodel (OG2) while the formation of matrix was exhibited in bigels with drug diffusion predominantly of non-Fickian type. Conclusion: Therefore, bigels of soybean oil based organogel with HPMCK4M hydrogel formed gel matrix demonstrating improved drug release for topical application compared to organogel.

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Section: Discussionsupporting

confidence: 79%

“…Ʈ=k*ɤ n ………….. 3Where the relationship between stress (Ʈ) and shear rate ( ɤ) give the values for flow consistency index (k) and flow behaviour index (n). The rheological behavior may be stated as non-Newtonian pseudoplastic/shear-thinning if the values of n is<1 [21,22].…”

Section: Spreadabilitymentioning

confidence: 99%

Formulation and in Vitro Characterisation of Soybean Oil-Hpmck4m Based Bigel Matrix for Topical Drug Delivery

Mukherjee¹,

Majee²,

Biswas³

2019

Int J App Pharm

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“…Since then, the interest in such systems has increased due to their physicochemical and functional properties (Deng et al, 2015;Kodela et al, 2017;Patel, Mankoč, Bin Sintang, Lesaffer, & Dewettinck, 2015;Wakhet et al, 2015). The main advantage of bigels is their ability to simultaneously act as a vehicle for hydrophilic and hydrophobic compounds (Behera, Sagiri et al, 2015;. In addition, the semi-solid nature of both phases confers to these gels higher thermodynamic and kinetic stability in comparison to other biphasic systems such as emulsions and emulgels (Kodela et al, 2017;Satapathy et al, 2015;Wakhet et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Modulating process parameters to change physical properties of bigels for food applications

et al. 2021

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The effect of the process parameters involved in the production of bigels was investigated through the study of structural, mechanical and rheological properties. Four level (2 4) Central Composite Rotational Design (CCRD) configuration was applied in order to study the organogelator concentration, hydrocolloid concentration, organogel:hydrogel ratio and shear of mixing. Gellan gum and high oleic sunflower oil with glycerol monostearate were used to produce hydrogels and organogels, respectively. All formulations were water-in-oil systems with gel-like behavior. FTIR and XRD results showed that bigels were formed only by physical arrangement with no chemical interactions, but gellan gum decreased the crystallinity of the systems due to its amorphous character. However, hydrogel particles acted as an active filler, reinforcing the structure in comparison to pure gels. Also, the glycerol monostearate present in the organogel could self-assemble at the interface in order to interact with the aqueous phase, improving the interaction and affinity between the phases. Moreover, depending on the composition, systems could be softer or harder and present some frequency dependence. CCRD showed that all parameters evaluated changed with organogel:hydrogel ratio and organogel concentration. Shear of mixing was also significant for some parameters; however, hydrocolloid concentration did not exert a significant effect on the range studied. From PCA analysis it was possible to distinguish different groups, which means that some conditions produced bigels with similar characteristics. Thus, it is expected that these results will allow customizing and fine-tuning properties of structured two-phase systems for diverse applications, ranging from food to pharmaceutical and cosmetic industries.

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“…Surprisingly, cellulose thinner, isopropylalcohol, and n -butylalcohol, when used as solvents, result in a clear gel without piperidine, whereas the addition of piperidine forms solutions. The gelation of sunflower oil indicates a promising potential application of L-Tyr( t Bu)-OH in the field of drug delivery 30 – 32 . Similarly, the gelation of diesel by L-Tyr( t Bu)-OH was observed, indicating a possible function in oil-spill recovery 3 , 10 .…”

Section: Resultsmentioning

confidence: 99%

Simple Tyrosine Derivatives Act as Low Molecular Weight Organogelators

Aykent

Zeytun

Marion

et al. 2019

Sci Rep

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The gelation of L-Tyr(tBu)-OH in tetrahydrofuran (THF) was discovered serendipitously. It was noted that this tremendously low molecular weight (LMW) compound has the ability to gel a wide variety of organic solvents (e.g., N,N-Dimetylformamide (DMF), THF, butanol, toluene), even in very low concentrations (i.e., 0.1 wt/v% in DMF). Addition of bases such as NaOH and piperidine enhanced the gel property. By changing the side-chain protecting group to tert-butyldimethylsilyl (TBDMS), a fluoride ion-responsive organogel was also acquired. This new organogelator responded fluoride ion concentration as low as 0.2 ppm. Characterization of microstructures and gel behaviours were studied by powder X-Ray diffraction spectroscopy (XRD), transmission electron microscopy (TEM), rheological measurements and molecular dynamics (MD) simulations. Experimental observations and theoretical simulations consistently show a fibre-like structure of the gel, in which the organogelator molecules are held together via a dense network of hydrogen bonds, and via van der Waals interactions between hydrophobic groups.

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Sunflower Oil and Protein-based Novel Bigels as Matrices for Drug Delivery Applications—Characterization andin vitroAntimicrobial Efficiency

Cited by 40 publications

References 55 publications

Formulation and in Vitro Characterisation of Soybean Oil-Hpmck4m Based Bigel Matrix for Topical Drug Delivery

Formulation and in Vitro Characterisation of Soybean Oil-Hpmck4m Based Bigel Matrix for Topical Drug Delivery

Modulating process parameters to change physical properties of bigels for food applications

Simple Tyrosine Derivatives Act as Low Molecular Weight Organogelators

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