Development and Physical Characterization of Polymer-Fish Oil Bigel (Hydrogel/Oleogel) System as a Transdermal Drug Delivery Vehicle

Rehman, Khurram; Amin, Mohd Cairul Iqbal Mohd; Zulfakar, Mohd Hanif

doi:10.5650/jos.ess14101

Cited by 86 publications

(72 citation statements)

References 22 publications

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“…16 The following points were noted: the bigel played a stabilizing role on the fish oil fatty acids, demonstrated excellent mechanical properties, and the drug permeation was enhanced. Olive oil, sesame oil, and fish oil are the oils most commonly used for the preparation of bigels.…”

Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

“…13,[15][16][17] Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers such as guar gum, gelatin, sodium alginate, hydroxypropyl methylcellulose, and carbopol. 12,[15][16][17] In a previous study, we established the stabilizing role of poly(vinyl acetate) (pVAc) nanocarriers on the included drug (indomethacin) and the possibility of a controlled release, provided by copolymers and polymeric mixtures with hydrophilic polymers. [18][19][20] In the present study, different in situloaded polymer carriers of KP were obtained by one stage emulsifier-free radical homopolymerization of vinyl acetate (VAc) and copolymerization of VAc and 2-(dimethylamino) ethyl methacrylate (DMAEMC).…”

Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

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Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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The purpose of the study was to investigate the stability and biopharmaceutical characteristics of ketoprofen, loaded in polymeric carriers, which were included into a bigel in a semisolid dosage form. The polymer carriers with in situ-included ketoprofen were obtained by emulsifier-free emulsion polymerization of the monomers in aqueous medium or a solution of the polymers used. The morphological characteristics of the carriers, the in vitro release and the photochemical stability of ketoprofen were evaluated. The model with optimal characteristics was included in a bigel formulation. The bigel was characterized in terms of pH, rheological behavior, spreadability, and in vitro drug release. Acute skin toxicity, antinociceptive activity, anti-inflammatory activity, and antihyperalgesic effects of the prepared bigel with ketoprofen-loaded polymer carrier were evaluated. The carriers of ketoprofen were characterized by a high yield and drug loading. The particle size distribution varied widely according to the polymer used, and a sustained release was provided for up to 6 hours. The polymer mixture poly(vinyl acetate) and hydroxypropyl cellulose as a drug carrier, alone or included in the bigel composition, improved the photostability of the drug compared with unprotected ketoprofen. The bigel with ketoprofen-loaded particles provided sustained release of the drug and had optimal rheological parameters. In vivo experiments on the bigel showed no skin inflammation or irritation. Four hours after its application, a well-defined analgesic, anti-inflammatory, and antihyperalgesic effect was registered. The polymer mixture of poly(vinyl acetate) and hydroxypropyl cellulose as a carrier of ketoprofen and the bigel in which it was included provided an enhanced photostability and sustained drug release.

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Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

Section: Ketoprofen ([Rs]2-[3-benzoylphenyl]-propionic Acid) (Kp) Is mentioning

confidence: 99%

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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show abstract

“…Olive oil [2], sesame oil [4,5], sunflower oil [6], soybean oil [1,7] and fish oil [8,9] are the most commonly used oils for bigel preparation. Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%

“…Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Andonova¹,

Peneva²,

Apostolova³

et al. 2017

Trop. J. Pharm Res

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“…Singh et al [8] studied the microscopic morphology of samples and the rheological properties in terms of viscosities and 'creep and recovery' tests; the same group carried out also small amplitude oscillation tests for similar systems [7] and fluorescent microphotographs were moreover taken in their work based on carbopol-based bigels [15]. Texture analysis (creep recovery tests) were also taken by Satapathy et al [4] in their study comparing gelatin-based hydrogels, emulsion hydrogels, and bigels, while Rehman et al [16] characterised the polarized optical microscopy, viscosity and texture properties of polymer-fish oil bigels. Finally, flourence microscopy and rheological tests (texture analysis, viscosity, stickiness and stress relaxation) was investigated by Behera et al [14].…”

Section: Introductionmentioning

confidence: 99%

Olive oil and hyperthermal water bigels for cosmetic uses

Lupi

Gentile

Gabriele

et al. 2015

Journal of Colloid and Interface Science

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Development and Physical Characterization of Polymer-Fish Oil Bigel (Hydrogel/Oleogel) System as a Transdermal Drug Delivery Vehicle

Cited by 86 publications

References 22 publications

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Olive oil and hyperthermal water bigels for cosmetic uses

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