Mohs Micrographic Surgery for Lentigo Maligna and Lentigo Maligna Melanoma. A Follow-up Study

Cohen, Lisa M.; McCall, Michael W.; Zax, Robert H.

doi:10.1111/j.1524-4725.1998.tb04226.x

Cited by 131 publications

(154 citation statements)

References 40 publications

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“…Case series have supported the efficacy of Mohs surgery for MIS, with longterm cure rates equaling or exceeding historical cure rates with conventional wide local excision. [42][43][44] In our study, more than half of all respondents reported the use of Mohs micrographic surgery in the surgical treatment of facial MIS, whereas most respondents favored traditional surgical excision for nonfacial lesions. This differential practice in treating facial vs nonfacial MIS is likely due to the finding that recurrence rates on the head and neck are especially high after local excision.…”

Section: Mohs Micrographic Surgerymentioning

confidence: 84%

Variation in the Diagnosis, Treatment, and Management of Melanoma In Situ

Charles

Yee²,

Dusza³

et al. 2005

Arch Dermatol

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Section: Mohs Micrographic Surgerymentioning

confidence: 84%

Variation in the Diagnosis, Treatment, and Management of Melanoma In Situ

Charles

Yee²,

Dusza³

et al. 2005

Arch Dermatol

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“…Although many authors have reported on recurrence rates, 3,9,21,24,26,27 only a few have obtained longterm (5-year) follow-up. 9,24,26 Additionally, results may not be comparable because follow-up methods are not always adequately described.…”

Section: Mohsmentioning

confidence: 99%

“…3,[24][25][26][27] However, since most recurrences of LM do not occur until 3 to 5 years after initial excision, long-term follow-up is needed to determine the success rate of any treatment modality. Although many authors have reported on recurrence rates, 3,9,21,24,26,27 only a few have obtained longterm (5-year) follow-up. 9,24,26 Additionally, results may not be comparable because follow-up methods are not always adequately described.…”

Section: Mohsmentioning

confidence: 99%

Management of Lentigo Maligna and Lentigo Maligna Melanoma With Staged Excision

Bub¹,

Berg²,

Slee³

et al. 2004

Arch Dermatol

165

133

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“…These other histologic types, such as lentigo maligna or dermatofibrosarcoma protuberans, are subject to much more variability in terms of MMS technique. 53,54 We therefore chose to focus on 1095 cases of nonmelanoma skin cancer treated according to standard MMS.…”

Section: Commentmentioning

confidence: 99%

Predictors of Extensive Subclinical Spread in Nonmelanoma Skin Cancer Treated With Mohs Micrographic Surgery

Batra¹

2002

Arch Dermatol

158

130

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Background: In nonmelanoma skin cancer, the clinically visible portion may represent a small fraction of microscopic tumor spread. Previous studies have examined individual risk factors for subclinical spread based on patient and tumor characteristics. However, these risk factors have not been prioritized or studied in combination.Objective: To identify the most predictive risk factors for extensive subclinical tumor spread.Design: Retrospective analysis of 1131 Mohs micrographic surgical cases. Variables analyzed included patient age, sex, and immune status and lesion size, location, histologic subtype, and recurrence. Logistic regression was applied to identify important combinations of tumor characteristics and to quantify relative odds of spread.Setting: Academic referral center.Patients: Consecutive sample of all referred patients treated by a single Mohs micrographic surgeon in a 3-year period.Main Outcome Measure: Number of Mohs micrographic surgical layers required to clear a tumor, with 3 or more layers defined as extensive subclinical spread.Results: The highest-risk tumors, with odds ratios greater than 6.0, were basosquamous and morpheaform basal cell carcinoma (BCC) on the nose, morpheaform BCC on the cheek, and those with a preoperative size greater than 25 mm. Other important risk factors were recurrent and nodular BCC on the nose; location on the eyelid, temple, or ear helix; neck tumors and recurrent BCC in men; and tumor size greater than 10 mm. Patients younger than 35 years were at lower risk. Increasing age and immunocompromise were not significant predictors. Conclusion:Identification of lesions likely to exhibit extensive subclinical spread can help guide management to ensure complete tumor eradication and thereby reduce the risk of recurrence and its associated morbidity and cost.

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Mohs Micrographic Surgery for Lentigo Maligna and Lentigo Maligna Melanoma. A Follow-up Study

Abstract: MMS using frozen and rush permanent sections resulted in a 97% cure rate for LM and LMM. Because MMS minimizes the removal of normal tissue, and the cure rate exceeds that of conventional therapies, the authors recommend this technique for the treatment of LM and LMM.

Cited by 131 publications

References 40 publications

Variation in the Diagnosis, Treatment, and Management of Melanoma In Situ

Variation in the Diagnosis, Treatment, and Management of Melanoma In Situ

Management of Lentigo Maligna and Lentigo Maligna Melanoma With Staged Excision

Predictors of Extensive Subclinical Spread in Nonmelanoma Skin Cancer Treated With Mohs Micrographic Surgery

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