Modulatory potential of ellagic acid, a natural plant polyphenol on altered lipid profile and lipid peroxidation status during alcohol‐induced toxicity: A pathohistological study

Abstract

Polyphenol-rich dietary foodstuffs, consumed as an integral part of vegetables, fruits, and beverages have attracted attention due to their antioxidant and anticancer properties. Ellagic acid (EA), a polyphenolic compound widely distributed in fruits and nuts, has been reported to scavenge free radicals and inhibit lipid peroxidation. Chronic consumption of alcohol potentially results in serious illness including hepatitis, fatty liver, hypertriglyceridemia, and cirrhosis. A little is known about the influence of EA on alcohol toxicity in vivo. Accordingly, in the present study, we have evaluated the protective effects of EA on lipid peroxidation and lipid levels during alcohol-induced toxicity in experimental rats. Forty female albino Wistar rats, which were weighing between 150-170 g were used for the study. The toxicity was induced by administration of 20% alcohol orally (7.9 g/kg body wt.) for 45 days. Rats were treated with EA at three different doses (30, 60, and 90 mg/kg body wt.) via intragastric intubations together with alcohol. At the end of experimental duration, liver marker enzymes (i.e., aspartate transaminase, alanine transaminase), lipid peroxidative indices (i.e., thiobarbituriacid reactive substances and hydroperoxides) in plasma, and lipid levels (i.e., cholesterol, free fatty acids, triglycerides and phospholipids) in tissues were analyzed to evaluate the antiperoxidative and antilipidemic effects of EA. Liver marker enzymes, lipid peroxidative indices, and lipid levels, i.e., cholesterol, triglycerides and free fatty acids, were significantly increased whereas phospholipid levels were significantly decreased in the alcohol-administered group. EA treatment resulted in positive modulation of marker enzymes, peroxidative indices, and lipid levels. EA at the dose of 60 mg/kg body wt. was found to be more effective when compared to the other two doses. Histological changes observed were also inconsistent with the biochemical parameters. Our study suggests that EA exerts beneficial effects at the dosage of 60 mg/kg body wt. against alcohol-induced damage, and it can be used as a potential drug for the treatment of alcohol-abuse ailments in the near future.

Feeding on ripening and over-ripening fruit: interactions between sugar, ethanol and polyphenol contents in a tropical butterfly

“…Indeed, polyphenol intake had no significant effects on oxidative damage and significantly decreased antioxidant defences. Lower oxidative damage as a result of polyphenol consumption has been reported by studies examining the oxidative status of animals consuming ethanol (Devipriya et al, 2007(Devipriya et al, , 2008Faremi et al, 2008;Kasdallah-Grissa et al, 2007). In contrast to these studies, ethanol consumption per se was not associated with pro-oxidant effects in our study.…”

“…Such adverse effects may, however, be reduced if frugivorous animals are able to benefit from antioxidant compounds present in fruit if ingested along with ethanol (Beaulieu and Schaefer, 2013). Indeed, several studies have shown that the pro-oxidant effects of ethanol disappear when it is consumed together with antioxidant compounds such as polyphenols (Devipriya et al, 2007(Devipriya et al, , 2008Faremi et al, 2008;Kasdallah-Grissa et al, 2007). Moreover, the solubility and the absorption of polyphenols can be enhanced when consumed in combination with ethanol (Manach et al, 2004;Scholz and Williamson, 2007).…”

Effects of Ellagic Acid on Copper, Zinc, and Biochemical Values in Serum and Liver of Experimental Cholestatic Rats

“…EA may decrease the utility of Zn thioniens and other Zn-containing enzymes like SOD and matrix metalloproteinases by its effective antioxidant property, maintaining the levels of Zn [15,16]. Decreased Cu levels during EA treatment maybe due to its effective metal-chelating property [29].…”

“…It occurs in various foods such as pomegranate, strawberry, grape, walnut, etc. Its antioxidative, antiinflammatory, anticarcinogenic, and anti-hyperlipidaemic activities have been shown in various in vitro and in vivo studies [15]. In addition, it has been reported that ellagic acid decreased the Cu levels and increased the Zn levels during alcohol-induced toxicity in experimental rats [16].…”

Influence of antihypertensive and metabolic drugs on fatty acids content of lipids in cardiomyocytes of rats with spontaneous hypertension

“…На нашу думку, елгацин нормалізує вміст ЖК у кардіоміоцитах завдяки прямому атирадикальному ефекту, який обумовлений наявністю фенольних гідроксильних угру-повань та стабільністю структури елагової кислоти, а також протекторного впливу на ензими, що беруть участь у рециркулюванні внутрішньоклітинного пулу глутатіону, за ра-хунок того, що рухомі атоми водню в складі фенольних гідроксилів, в першу чергу, є до-наторами водню для ензимів, залежних від NADP-H. результати інших досліджень також свідчать про здатність амлодипіну та елагової кислоти впливати на рівень ЖК у плазмі крові, щодо бісопрололу -даних в літературі не знайдено [19,20].…”