Effects of Ellagic Acid on Copper, Zinc, and Biochemical Values in Serum and Liver of Experimental Cholestatic Rats

Gümüş, Metehan; Yüksel, Hatice; Evliyaoğlu, Osman; Kapan, Murat; Böyük, Abdullah; Önder, Akın; Aldemir, Mustafa

doi:10.1007/s12011-010-8863-2

Cited by 19 publications

(9 citation statements)

References 25 publications

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“…2), which is characteristic of all groups of rats with induced cancer, irrespectively of the applied supplementation, resulted from the discussed earlier drastic decrease of iron content in the serum of the examined rats as compared with the control group. The fact of an altered ratio of elements in the blood of patients suffering from different types of cancer, including breast cancer, irrespectively of the diet, was also observed in other investigations [40, 41]. …”

Section: Discussionsupporting

confidence: 69%

Copper and Resveratrol Attenuates Serum Catalase, Glutathione Peroxidase, and Element Values in Rats with DMBA-Induced Mammary Carcinogenesis

Skrajnowska

Bobrowska-Korczak

Tokarz

et al. 2013

Biol Trace Elem Res

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In this paper, a hypothesis was assessed whether or not the intoxication with copper and supplementation with copper plus resveratrol would result in changes in the activities of catalase and glutathione peroxidase and moreover if the characteristic changes would appear in concentrations of copper, iron, calcium, magnesium, and zinc in the serum of rats with chemically induced carcinogenesis. Female Sprague-Dawley rats were divided into study groups which, apart from the standard diet, were treated with copper (42.6 mg Cu/kg food as CuSO4·5H2O) or copper plus resveratrol (0.2 mg/kg body) via gavage for a period from 40 days until 20 weeks of age. In cancer groups, the rats were treated with a dose of 80 mg/body weight of 7,12-dimethyl-1,2-benz[a]anthracene (DMBA) given in rapeseed oil at 50 and 80 days of age to induce mammary carcinogenesis. The control groups included the rats kept in the same conditions and fed with the same diet as the animals from the study groups, but not DMBA-treated. The activity of catalase significantly decreased in groups of rats with mammary carcinogenesis that were supplemented with copper (p < 0.05) or copper plus resveratrol (p < 0.001) in comparison with the control groups that received the same diets. In cancer groups of nonsupplemented rats, the increase of glutathione peroxidase activity was observed. The process of carcinogenesis and the applied supplementation significantly altered the concentrations of trace elements in serum, in particular as concerns iron and copper. The mean serum iron levels in rats with breast cancer were significantly lower than those in the control groups (p < 0.001). The mean serum copper levels significantly decreased in the groups of rats with mammary carcinogenesis that were supplemented with copper or copper plus resveratrol in comparison with the control groups that received the same diets (p < 0.001). The characteristic changes in iron content and the zinc/copper and zinc/iron ratios in blood may be used as one of the prognostic factors in breast cancer research.

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Section: Discussionsupporting

confidence: 69%

Copper and Resveratrol Attenuates Serum Catalase, Glutathione Peroxidase, and Element Values in Rats with DMBA-Induced Mammary Carcinogenesis

Skrajnowska

Bobrowska-Korczak

Tokarz

et al. 2013

Biol Trace Elem Res

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“…Walnuts, tomatoes, grape juice, blackberries, carrots, grape wine, pomegranate, strawberries and blueberries have been shown to comprise EA 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis

et al. 2016

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PURPOSE:To investigate the therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis in rats. METHODS:Thirty-two were split into four groups. Group 1 (control) rats were performed only laparotomy, no drugs were administered. Group 2 (control+EA) rats were administered 85mg/kg EA orally. Rats were sacrificed by cardiac puncture 24 hours after the administration. Group3 (AP) 24 hours after intraperitoneal L-arginine administration, rats were sacrificed by cardiac puncture.Group 4 (EA)-(AP): 85mg/kg EA was administered orally after the L-arginine administration. 24 hours later, rats were sacrificed by cardiac puncture. Serum TNF-α, IL-1β, IL-6, total oxidative status (TOS), total antioxidant capacity (TAC), amylase levels were determined in all groups. RESULTS:Group 3 (AP) rats showed significantly raised TOS level as compared to Group1 (control) rats (p<0.001). Following the EA therapy, a decrease in TOS was observed in Group 4 (AP+EA). TAC levels were significantly raised in the Group 4 (AP+EA) compared to the Group 3 (AP) (p=0.003). Group 3 (AP) showed significantly increased TNF-α, IL-1β and IL-6 serum levels as compared to Group 4 (AP+EA). Histopathological changes were supported our result. CONCLUSION:The healing effects of ellagic acid on inflammatory and oxidative stress were confirmed by histopathological and biochemical evaluations of the pancreatic tissue.

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“…D'Uscio et al (14) found that treatment with EPO increased the vascular ex pression of SOD1 (superoxide dismutase). Although modulatory effects of EPO on Cu and Zn levels in certain liver and kidney diseases have been reported in some studies, its effects in OJ have not been clarified (3,15). In general, the increase of Cu and decrease of Zn levels in the liver tissue and serum may be the characteristics of chronic diseases, such as severe cholestasis, biliary atresia and cirrhosis (16,17).…”

Section: Discussionmentioning

confidence: 99%

“…The release of free oxygen radicals, due to bile acid damage, results in interference with Kupffer cells and neutrophils, and this clinical picture may not be limited to the liver, but its systemic effects could cause damage of various organs (2). OJ causes dilatation in hepatocytes and bile ducts, and due to high concentrations of hydrofobic bile acids it causes oxidative damage and inflammation (3). Mediators liberated as a result of oxidative damage, by increasing the quantity of free radicals, cause activation of the coagulation cascade, impairment of microcirculation and clinical pictures which may lead to multiple organ failure (4).…”

Section: Introductionmentioning

confidence: 99%

Effects of Erythropoietin on the Serum and Liver Tissue Levels of Copper and Zinc in Rats with Obstructive Jaundice / Efekti Eritropoetina Na Nivoe Bakra I Cinka U Serumu I Tkivima Jetre Kod Pacova Sa Opstruktivnom Žuticom

Aliosmanoglu¹,

Kapan²,

Gül³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: Erythropoietin is an anti-apoptotic, anti-inflammatory, angiogenetic cytokine and has protective properties against oxidative stress. In this study we investigated the effects of erythropoietin on the le vels (serum and liver tissue) of copper and zinc in cholestatic rats. Methods: Thirty-two Wistar albino rats used in the study were divided into four groups -Group I: Sham; Group II: Erythropoietin; Group III: Obstruc tive Jaundice; Group IV: Obstructive Jaundice+Erythro poietin. After the first operation, rats were followed up for seven days and then operated for the second time. Rats were sacrificed by intracardiac blood taking, and the liver tissue samples were obtained immediately. Results: Erythropoietin reduces copper, and increases zinc levels in serum and liver tissues after obstructive jaundice (p<0.05). Furthermore, it has been shown that the levels of alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, alkaline phosphatase and total bilirubin/direct bilirubin were significantly lower in Obstructive Jaundice+Erythropoietin group than Obstructive Jaundice group. Conclusions: Erythropoietin affects the changes in copper and zinc levels, thus decrea sing the liver damage biochemically in rats with obstructive jaundice. However, further investigations are needed to discover how erythropoietin therapy might reduce target organ damage in cholestatic liver cases by affecting copper and zinc levels.

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Effects of Ellagic Acid on Copper, Zinc, and Biochemical Values in Serum and Liver of Experimental Cholestatic Rats

Cited by 19 publications

References 25 publications

Copper and Resveratrol Attenuates Serum Catalase, Glutathione Peroxidase, and Element Values in Rats with DMBA-Induced Mammary Carcinogenesis

Copper and Resveratrol Attenuates Serum Catalase, Glutathione Peroxidase, and Element Values in Rats with DMBA-Induced Mammary Carcinogenesis

Therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis

Effects of Erythropoietin on the Serum and Liver Tissue Levels of Copper and Zinc in Rats with Obstructive Jaundice / Efekti Eritropoetina Na Nivoe Bakra I Cinka U Serumu I Tkivima Jetre Kod Pacova Sa Opstruktivnom Žuticom

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