Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin–nicotinamide diabetic rats

Abstract

Spices which show hypoglycaemic, hypolipidaemic and antioxidant activities may have a role in the treatment of diabetes and its complications. The present study aimed to compare the modulatory effects of garlic, ginger, turmeric and their mixture on the metabolic syndrome and oxidative stress in streptozotocin (STZ) -nicotinamide diabetic rats. Diabetes was induced in overnight fasted rats by a single intraperitoneal injection of STZ (65 mg/kg body weight) and nicotinamide (110 mg/kg body weight, 15 min before STZ injection). Diabetic rats orally received either distilled water (as vehicle) or 200 mg/kg body weight of garlic bulb, ginger rhizome or turmeric rhizome powder suspension separately or mixed together (GGT mixture) for twenty-eight consecutive days. The results showed that these spices and their mixture significantly alleviated (80 -97 %, P, 0·05 -0·001) signs of the metabolic syndrome (hyperglycaemia and dyslipidaemia), the elevation in atherogenic indices and cellular toxicity in STZ -nicotinamide diabetic rats by increasing the production of insulin (26-37 %), enhancing the antioxidant defence system (31 -52 %, especially GSH) and decreasing lipid peroxidation (60 -97 %). The greatest modulation was seen in diabetic rats that received garlic and the GGT mixture (10 -23 % more than that in the ginger and turmeric groups). In conclusion, garlic or the mix including garlic appears to have an impact on each of the measures more effectively than ginger and turmeric and may have a role in alleviating the risks of the metabolic syndrome and cardiovascular complications.

Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe

“…Although several studies have mentioned antidiabetic activity of Zingiber officinale (Grover et al, 2002;Akhani et al, 2005;Kelble, 2005;Al-Amin et al, 2006;Büyükbalci, Sedef, 2008;Islam, Choi, 2008;Abd-Elraheem et al, 2009;Saraswat et al, 2009;Ogbera et al, 2010;Saraswat et al, 2010;Madkor et al, 2011;Ramudu et al, 2011;Rani et al, 2011), no data is available on protein glycation and glucose absorption inhibitory potential of native Zingiber officinale rhizomes at national level. The present study was undertaken to investigate the antidiabetic effects of Zingiber officinale in terms of glucose diffusion and glycation inhibition.…”

Effect of Anogeissus leiocarpus Guill and Perr Leaf on Hyperglycaemia and Associated Dyslipidaemia in Alloxan-induced Diabetic Rats

“…5,10,11 It has also been shown that plant nutrients play protective roles against oxidative stress in diabetic rats. 15,16 The ability of the A. leiocarpus ethanolic leaf extract to protect the rats against oxidative stress could be attributed to its hypoglycaemic principles. [17][18][19][20] The mechanism of action that brings about the hypoglycaemic effect may be by increasing either the pancreatic secretion of insulin from β-cells of the islet of Langerhans or its release from pro-insulin form.…”

Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

“…Type 2 diabetes mellitus is related to defects in insulin release or lipid and glucose metabolisms [36] . Prevention and treatment of diabetes are among the priority issues.…”