Modulatory effect of Prosopis juliflora leaves on hepatic fibrogenic and fibrolytic alterations induced in rats by thioacetamide

Hassan, Samah; Taha, AlShaimaa M.; Eldahshan, Omayma A.; Sayed, Ahmed; Salem, Ahmed M.

doi:10.1016/j.biopha.2019.108788

Cited by 12 publications

(9 citation statements)

References 71 publications

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“…Based on the plant cytotoxicity and the present results of IC 50 on the different cancer cells, it was clear that the plant leave extract showed higher cytotoxic specificity against the breast cancer cell line, MCF-7, rather than the other cancer cell lines; HePG2 and LS-174T, of liver and colorectal cancer, respectively. Our results were consistent to recent study reported that MCF-7 is highly sensitive to the killing effect of P. juliflora methanol extract that exerting low IC 50 ; 19.4 μg/ml (Hassan et al, 2019[ 15 ]). The time, order and sequence of cell cycle events are monitored by the checkpoints occurred at the G1/S boundary, S-phase, and G2/M-phases (MacLachlan et al, 1995[ 23 ]).…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, other studies reported the potency of P. juliflora extract in inhibiting cancer cell growth (Sathiya and Muthuchelian, 2011[ 29 ]). Recent studies have shown variant cytotoxic potencies of P. juliflora extracts against the breast/MCF-7 (Gurushidhappa et al, 2018[ 12 ]) or the liver/HePG2 (Hassan et al, 2019[ 15 ]) cancer cells showing strong cytotoxic effect. On the other hand, no study investigated the effects of P. juliflora on the colorectal cancer cell line, but other Prosopis species, i.e.…”

Section: Introductionmentioning

confidence: 99%

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Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell lines

Elbehairi

Ahmed

Alshati

et al. 2020

EXCLI Journal; 19:Doc1282; ISSN 1611-2156

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell lines

Elbehairi

Ahmed

Alshati

et al. 2020

EXCLI Journal; 19:Doc1282; ISSN 1611-2156

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“…In an attempt to shed light on the mechanisms involved in the cell-matrix degradation (ECM), we also evaluated the mRNA expression of MMP-9. It is known that extracts containing plant secondary metabolites can be associated with a reduction in fibrosis [38]. We demonstrated that the administration of resveratrol and ε-viniferin also exerted hepatoprotective effects against TAA damage, possibly via downregulation of MMP-9 mRNA expression, leading to an inhibition of cell-matrix degradation caused by TAA (Figure 5).…”

Section: Discussionmentioning

confidence: 71%

Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression

et al. 2021

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Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory development an in vivo model of severe acute liver failure induced with TAA. Trans-resveratrol + trans-ε-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + ε-viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in the treated group. This stilbene combination reduced the expression of TNFα, iNOS, and COX-2, and inhibited MMP-9. The combination of resveratrol + ε-viniferin had a hepatoprotective effect, reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD, CAT, and GST activities; by downregulating TNFα, COX-2, and iNOS; and upregulating IL-10. Our results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than resveratrol alone, opening a new perspective on using this stilbene combination in functional diets.

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“…Potent MMP-2 enzyme inhibition was also observed with caffeic acid derivatives such as esters and amides 71 , 72 . Furthermore, isorhamnetin-3-O-rutinoside is a polyphenolic flavone found in many herbal species that can depress MMP-2 levels in various conditions 73 , 74 . The combined presence of these top scored compounds affecting MMP-2 in As-ar and At-rt may explain the observed less hepatic MMP-2 levels in rats treated with these extracts than other treated groups.…”

Section: Discussionmentioning

confidence: 99%

Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study

Ibrahim

El–Mezayen

El‐Banna

2022

Sci Rep

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Liver cirrhosis is a late-stage liver disease characterized by excessive fibrous deposition triggering portal-hypertension (PH); the prime restrainer for cirrhosis-related complications. Remedies that can dually oppose hepatic fibrosis and lower PH, may prevent progression into decompensated-cirrhosis. Different Astragalus-species members have shown antifibrotic and diuretic actions with possible subsequent PH reduction. However, A.spinosus and A.trigonus were poorly tested for eliciting these actions. Herein, A.spinosus and A.trigonus roots and aerial parts extracts were subjected to comprehensive metabolic-fingerprinting using UHPLC-MS/MS resulting in 56 identified phytoconstituents, followed by chemometric untargeted analysis that revealed variable metabolic profiles exemplified by different species and organ types. Consequently, tested extracts were in-vivo evaluated for potential antifibrotic/anticirrhotic activity by assessing specific markers. The mechanistic prospective to induce diuresis was investigated by analyzing plasma aldosterone and renal-transporters gene-expression. Serum apelin and dimethylarginine-dimethylaminohydrolase-1 were measured to indicate the overall effect on PH. All extracts amended cirrhosis and PH to varying extents and induced diuresis via different mechanisms. Further, An OPLS model was built to generate a comprehensive metabolic-profiling of A.spinosus and A.trigonus secondary-metabolites providing a chemical-based evidence for their efficacious consistency. In conclusion, A.spinosus and A.trigonus organs comprised myriad pharmacologically-active constituents that act synergistically to ameliorate cirrhosis and associated PH.

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Modulatory effect of Prosopis juliflora leaves on hepatic fibrogenic and fibrolytic alterations induced in rats by thioacetamide

Cited by 12 publications

References 71 publications

Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell lines

Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell lines

Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression

Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study

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