Modulations in human neutrophil metabolome and S-glutathionylation of glycolytic pathway enzymes during the course of extracellular trap formation

Awasthi, Deepika; Nagarkoti, Sheela; Sadaf, Samreen; Aggarwal, Hobby; Gupta, Sonu Kumar; Chandra, Tulika; Kumar, Yashwant; Kumar, Sachin; Dikshit, Madhu

doi:10.1016/j.bbadis.2022.166581

Cited by 4 publications

(1 citation statement)

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“…In general, under normal conditions, nuclei DNA strands in neutrophils are highly wrapped around histones into heterochromatin with protein-DNA interactions to constrain the potential energy for DNA extension and transcriptional activity ( Shao et al, 2021a ; Sorensen & Borregaard, 2016 ). However, in the challenge of certain stimuli such as exogenous invasion, intracellular calcium ion flux and agents including lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA), the condensed DNA strands in nucleus are uncoiled as fibrous polymers and released outside the nucleus to form NETs ( Awasthi et al, 2023 ; Domer et al, 2021 ; Radermecker et al, 2019 ; Shao et al, 2021a ). Based on the current knowledge, two proteases are vital in the process of NET formation, namely peptidyl arginine deiminase 4 (PAD4) and NE ( Al-Kuraishy et al, 2022 ; Shao et al, 2021a ; Zhu et al, 2022 ).…”

Section: Part I: Biological Features Of Netsmentioning

confidence: 99%

Neutrophil extracellular traps in central nervous system (CNS) diseases

Shao,

Jiang,

Zhao

et al. 2024

PeerJ

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Excessive induction of inflammatory and immune responses is widely considered as one of vital factors contributing to the pathogenesis and progression of central nervous system (CNS) diseases. Neutrophils are well-studied members of inflammatory and immune cell family, contributing to the innate and adaptive immunity. Neutrophil-released neutrophil extracellular traps (NETs) play an important role in the regulation of various kinds of diseases, including CNS diseases. In this review, current knowledge on the biological features of NETs will be introduced. In addition, the role of NETs in several popular and well-studied CNS diseases including cerebral stroke, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), and neurological cancers will be described and discussed through the reviewing of previous related studies.

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