Modulation of the ubiquitin-proteasome system by marine natural products

Vasilopoulou, Mary A.; Iοannou, Efstathia; Roussis, Vassilios; Chondrogianni, Niki

doi:10.1016/j.redox.2021.101897

Cited by 14 publications

(8 citation statements)

References 227 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nair S et al found that cathepsin K may be a feasible drug target for the treatment of DOXinduced cardiotoxicity [29]. Based on the TCM theories on CHF therapy [30], the methodology has focused on using native compounds against DOX-induced cardiac toxicity. Previous studies have found that Chinese herbal medicines, date palm pollen extract and liensinine, can alleviate the DOX-induced cardiotoxicity [31,32].…”

Section: Discussionmentioning

confidence: 99%

Shenlijia Attenuates Doxorubicin-Induced Chronic Heart Failure by Inhibiting Cardiac Fibrosis

Sun

Song

Xie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Application of the anticancer drug doxorubicin (DOX) is restricted due to its adverse, cardiotoxic side effects, which ultimately result in heart failure. Moreover, there are a limited number of chemical agents for the clinical prevention of DOX-induced cardiotoxicity. Based on the theories of traditional Chinese medicine (TCM) on chronic heart failure (CHF), Shenlijia (SLJ), a new TCM compound, has been developed to fulfill multiple functions, including improving cardiac function and inhibiting cardiac fibrosis. In the present study, the protective effects and molecular mechanisms of SLJ on DOX-induced CHF rats were investigated. The CHF rat model was induced by intraperitoneal injection of DOX for six weeks with the cumulative dose of 15 mg/kg. All rats were then randomly divided into the control, CHF, CHF + SLJ (3.0 g/kg per day), and CHF + captopril (3.8 mg/kg per day) groups and treated for further four weeks. Echocardiography and the assessment of hemodynamic parameters were performed to evaluate heart function. A protein chip was applied to identify proteins with diagnostic values that were differentially expressed following SLJ treatment. The data from these investigations showed that SLJ treatment significantly improved cardiac function by increasing the left ventricular ejection fraction, improving the hemodynamic index, and inhibiting interstitial fibrosis. Protein chip analysis revealed that SLJ upregulated MCP-1, MDC, neuropilin-2, TGF-β3, thrombospondin, TIE-2, EG-VEGF/PK1, and TIMP-1/2/3 expressions and downregulated that of MMP-13. In addition, immunohistochemistry and western blot results further confirmed that SLJ promoted TIMP-1/2/3 and inhibited MMP-13 expression. The results of the present study suggest that SLJ was effective against DOX-induced CHF rats and is related to the improvement of heart function and ultrastructure and the inhibition of myocardial fibrosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Shenlijia Attenuates Doxorubicin-Induced Chronic Heart Failure by Inhibiting Cardiac Fibrosis

Sun

Song

Xie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In this respect, a challenge facing the aging population is to decrease the impact of aging on health and avoid the occurrence and development of age-related diseases. The plethora of literature has supported that bioactive compounds from traditional Chinese medicine or natural products could be an effective and safe strategy to protect against aging and age-related diseases [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Zhou

Luo

Huang

et al. 2021

Oxidative Medicine and Cellular Longevity

150

View full text Add to dashboard Cite

The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.

show abstract

“…Due to the low number of studies reporting the effects of marine natural products on the proteasome [ 26 ], we initially screened a panel of structurally diverse compounds isolated from marine macro- and micro-organisms for their potential to act as structural proteasome activators, thus activating the proteasome in cell-free lysates through direct stereochemical alterations. We selected and tested 24 metabolites belonging to different chemical classes, including sesquiterpenes, diterpenes, triterpenes, steroids, carotenoids, acetogenins, nitrogenous compounds and sulfur-containing compounds, obtained from marine organisms of the eastern Mediterranean Sea ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…It is worth noting that the majority of the natural products that have been described for their anti-aggregation properties and neuroprotective effects on AD models are of terrestrial origin, while only few are derived from marine organisms [ 26 ]. Marine metabolites, quite less explored as compared to compounds of terrestrial origin, often feature diversified chemical structures with novel carbocycles or uncommon functional groups, displaying more potent biological activities.…”

Section: Introductionmentioning

confidence: 99%