Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Abstract

The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.

Pharmacological Approaches to Decelerate Aging: A Promising Path

“…Studies have shown that resveratrol has beneficial effects on longevity in Drosophila melanogaster [ 160 ], Caenorhabditis elegans [ 160 ], Saccharomyces cerevisiae [ 161 ], Nothobranchius furzeri [ 162 ], and Honey bees [ 163 ]. Many studies have also been performed on mice, rats, and human cells [ 164 ].…”

“…Disorders such as memory loss or cognitive impairments that occur following aging can be due to oxidative stress, inflammation, and apoptosis in neurons as well as dysregulation in autophagy [ 167 , 166 ]. The antiaging effect of resveratrol in neurodegenerative diseases is due to its neuroprotective effects and by means of reducing inflammation and oxidative stress in neurons, as well as increasing neurogenesis and secretion of neurotransmitters [ 164 ].…”

“…Consumption of red wine which is rich in resveratrol has been reported to reduce the incidence of CVDs [ 168 ]. Resveratrol encompasses its cardioprotective effects by regulating the renin-angiotensin system (RAS) and increasing nitric oxide (NO) production, as well as reducing oxidative stress [ 164 ].…”

Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

“…With the accumulation and oxidation of fatty acids in the liver, the antioxidants are consumed and excessive reactive oxygen species are produced, gradually destroying the structure and function of hepatocytes and eventually accelerating the process of NAFLD (33,34). MDA is a representative product of lipid peroxidation (35). This study found that HFD led to an escalating trend of MDA level in mice, while some green teas, namely, Jieyang Chaoqing Tea (GT2) and Fenggang Zinc-Selenium-Enriched Tea (GT3), could significantly lower the MDA level, hence inhibiting the lipid peroxidation and oxidative stress.…”

Dietary resveratrol improved production performance, egg quality, and intestinal health of laying hens under oxidative stress

“…Resveratrol (trans-3, 5, 40-trihydroxytilbene; RV ) is a naturally polyphenol compound found in berries, nuts, skins of grapes and thus in red wine ( Jang et al., 1997 ). RV has antioxidant, antitumor, antiviral, and free radical scavenging properties, that is thought to be an effective compound for the prevention aging and age-related diseases ( Li et al., 2018 ; Nunes et al., 2018 ; Zhou et al., 2021 , Wang et al., 2021 ). Also, RV is associated with protection against oxidative stress of ovary to increase follicle numbers and prolong the ovary life-extending effect in human and rat model ( Liu et al., 2013 ; Li and Liu, 2018 ; Ochiai and Kuroda, 2019 ).…”