Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives

Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis

“…Chrysin is present in honey, propolis, and other plants and herbs (5). Chrysin was initially identified for its anti-oxidant effects and has been shown to possess cancer chemopreventive and anti-tumor effects (6)(7)(8). It inhibits proliferation and induces apoptosis in a variety of cancer cells in vitro, including cells from the prostate, skin, breast, lung, cervix, thyroid cancer and leukemia (5,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Anti-asthmatic potential of chrysin on ovalbumin-induced bronchoalveolar hyperresponsiveness in rats

“…Some of the pathways implicated comprise those involving the Src-family tyrosine kinases, the serine/threonine kinases protein kinase A and C, mitogen-activated protein kinase and protein kinase B/ Akt. Certain flavonoids including chrysin, luteolin, apigenin, quercetin, kaempferol have been reported previously to inhibit protein kinase B/Akt, COX/LOX, NF-kB, iNOS, protein kinase C, tyrosine kinase and phospholipases A2 and C (Cho et al, 2004;Comalada et al, 2006;Chen et al, 2007). The structural analogues of chrysins such as apigenin ) and luteolin (Das et al, 2003) demonstrated an ability to reduce OVAinduced asthmatic conditions in experimental animals.…”

“…Anti-asthmatic potential of chrysin on ovalbumin-induced bronchoalveolar hyperresponsiveness in rats (Caprifoliaceae) (Rahman Kang, 2009), Cyclanthera pedata Scrabs (Caigua) (Montoro et al, 2005), and bee propolis (Burdock, 1998), was reported to possess inhibition of IgE and Th2 cytokine (Yano et al, 2007), inhibition of cyclooxygenase (COX), inducible nitric oxide synthase (iNOS) (Liang et al, 2001;Cho et al, 2004;Hougee et al, 2005;Woo et al, 2005;Comalada et al, 2006;Harris et al, 2006), and hypoxia-inducible factor-1 expression (Fu et al, 2007).…”

Natural Flavonoids in StAR Gene Expression and Testosterone Biosynthesis in Leydig Cell Aging

“…The modification significantly improves the activities of the derivatives in inhibiting COX2. Some of the chrysin derivatives are able to bind to COX2 molecule and selectively inhibit COX2 activity (Cho et al, 2004;Dao et al, 2004). Chrysin has been described as a testosterone-increasing agent that blocks further testosterone metabolism by inhibiting aromatase activity (Dhawan et al, 2002;Kellis & Vickery, 1984).…”