Anti-asthmatic potential of chrysin on ovalbumin-induced bronchoalveolar hyperresponsiveness in rats

Wadibhasme, Pankaj G.; Ghaisas, Mahesh M.; Thakurdesai, Prasad

doi:10.3109/13880209.2010.521754

Cited by 38 publications

(17 citation statements)

References 38 publications

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“…Chrysin (C 15 H 10 O 4 ) has been shown to be a very active flavonoid exerting some pharmacological properties, such as anti-inflammatory activity through blocking histamine release and expression of proinflammatory cytokines [44,45]. Antiasthmatic activity occurs via suppressing the nuclear factor-kB (NF-kB) and inducible nitric oxide synthase (iNOS) [46]. The anticancer activity of chrysin was also reported [47,48], as well antihypercholesterolemic and cardioprotective activities [49,50].…”

Section: Discussionmentioning

confidence: 99%

Ginger Water Reduces Body Weight Gain and Improves Energy Expenditure in Rats

Sayed

Ahmed

El-Shehawi

et al. 2020

Foods

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Obesity is a serious global problem that causes predisposition to numerous serious diseases. The current study aims to investigate the effect of ginger water on body weight and energy expenditure through modulation of mRNA expression of carbohydrate and lipid metabolism. A white colored liquid obtained during freeze-drying of fresh rhizomes of Zingiber officinal was collected and named ginger water. It was used to treat rats, then blood and tissue samples were collected from the liver and white adipose at the end of the experiment. The serum was prepared and used for biochemical assays, while tissue samples were used for RNA isolation and gene expression analysis via Reverse transcription polymerase chain reaction (RT-PCR). Results of High Performance Liquid Chromatography (HPLC) analysis of ginger water revealed the presence of chrysin and galangin at concentrations of 0.24 µg/mL and 0.53 µg/mL, respectively. Average body weight gain decreased significantly in groups that received ginger water. In addition, both total cholesterol and serum triacylglycerol were reduced in the groups that received ginger water. Furthermore, mRNA expression of Sterol regulatory element-binding protein 1 (SREBP-1c) in the liver and leptin in adipose tissues were downregulated, while those of adiponectin, hepatic carnitine palmitoyltransferase1 (CPT-1), acyl-coA oxidase (ACO), Glucose transporter 2 (GLUT-2), and pyruvate kinase (PK) were upregulated in ginger water-treated groups. These results clearly revealed the lowering body weight gain effect of ginger water, which most likely occurs at the transcriptional level of energy metabolizing proteins.

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Section: Discussionmentioning

confidence: 99%

Ginger Water Reduces Body Weight Gain and Improves Energy Expenditure in Rats

Sayed

Ahmed

El-Shehawi

et al. 2020

Foods

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“…They suggested that antiasthmatic effects of CH may be related to the modulation of Th1/Th2 via suppressing iNOS and NF-κB. 19 …”

Section: Methodsmentioning

confidence: 99%

Protective Effects of Chrysin Against Drugs and Toxic Agents

2017

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Issues:Polyphenolic compounds, especially flavonoids, are known as the most common chemical class of phytochemicals, which possess a multiple range of health-promoting effects. Flavonoids are ubiquitous in nature. They are also present in food, providing an essential link between diet and prevention of several diseases.Approach:Chrysin (CH), a natural flavonoid, was commonly found in propolis and honey and traditionally used in herbal medicine. A growing body of scientific evidence has shown that CH possesses protective effects against toxic agents in various animal tissues, including brain, heart, liver, kidney, and lung.Key Findings:This study found that CH may be effective in disease management induced by toxic agents. However, due to the lack of information on human, further studies are needed to determine the efficacy of CH as an antidote agent in human.Conclusion:The present article aimed to critically review the available literature data regarding the protective effects of CH against toxic agent–induced toxicities as well as its possible mechanisms.

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“…It has been reported that chrysin has various beneficial pharmacological properties, including anti-oxidant (Bors andSaran, 1987, Lapidot et al, 2002), anti-hypertensive (Villar et al, 2002), anti-cancer (Li et al, 2010) and anti-estrogenic (Wang and Kurzer, 1998) effects. Reports showed that chrysin could attenuate airway inflammation by modulating Th1/Th2 polarization through suppressing the inducible nitric oxide synthase (iNOS) and nuclear factor-κB (NF-κB) (Wadibhasme et al, 2011, Du et al, 2012. Also, chrysin pretreatment inhibited phosphorylation extracellular signal-regulated kinase (ERK), p38 and inflammatory cytokines release in mice induced with airway inflammation .…”

Section: Introductionmentioning

confidence: 99%