Modulation of object memory consolidation by heroin and heroin-conditioned stimuli: Role of opioid and noradrenergic systems

Wolter, Michael; Huff, Andrew E.; Baidoo, Nana; Jardine, Kristen H.; Pulles, Zoey; Winters, Boyer D.; Leri, Francesco

doi:10.1016/j.euroneuro.2020.01.010

Cited by 16 publications

(35 citation statements)

References 74 publications

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“…Contextual conditioning was conducted in six semitransparent Plexiglas compartments (30 × 40 × 26 cm) as described by Wolter et al 3,7 Locomotion was measured by automatic video tracking (EthoVision v3, Noldus, The Netherlands).…”

Section: Methodsmentioning

confidence: 99%

“…After a 72‐h retention interval, each animal was tested on a choice phase for 2 min, during which a copy of the sample object was presented in one arm and a novel object in the other. A 72‐h retention interval was used because it is a suboptimal condition in which drug‐naive rats do not show object memory 3,7,24 . All animals were tested twice, once with 0 NTX and once with 3 NTX, in a counterbalanced order, and the two sample/ choice OR sessions were separated by 24 h. After the last choice phase, the minipumps were removed, and 7 days later, the entire OR testing protocol was repeated.…”

Section: Methodsmentioning

confidence: 99%

“…One aspect of direct drug reinforcement is the enhancement of consolidation of memories for stimuli and behaviors linked to drug intake 2 . In fact, experimental posttraining administration of drugs of abuse such as alcohol, opioids, cocaine, nicotine, and amphetamine can improve the performance of various learning tasks 3–7 . Interestingly, it is possible that the persistence of behaviors aimed at avoiding the highly aversive affective state of drug withdrawal (hyperkatifeia) 8 also involves an action on memory consolidation.…”

Section: Introductionmentioning

confidence: 99%

“…As well, opioid withdrawal stimulates the release stress hormones 13,14 and facilitates cholinergic neurotransmission, 15 also key processes involved in the stabilization of memory traces 12 . Finally, considering that opioid withdrawal can be triggered by environmental stimuli that have been consistently paired with this state 16,17 and that posttraining exposure to environments paired with the effects of drug reinforcers enhances memory consolidation, 3,7 it is conceivable that conditioned withdrawal could also enhance memory consolidation.…”

Section: Introductionmentioning

confidence: 99%

“…The first objective of this study was to ascertain whether acute precipitated morphine withdrawal could impact consolidation of memory tested by the spontaneous object recognition (OR) task. This task is based on rodents' innate preference to explore novel versus familiar objects 18 and was chosen because of its sensitivity to posttraining administration of cocaine, nicotine, and heroin 3,7 . The second objective was to ascertain whether a context paired with instances of acute precipitated morphine withdrawal could also impact OR memory.…”

Section: Introductionmentioning

confidence: 99%

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The effects of morphine withdrawal and conditioned withdrawal on memory consolidation and c‐Fos expression in the central amygdala

et al. 2020

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The current study tested the hypothesis that drug withdrawal contributes to the addiction cycle in part because of an action on memory consolidation. Hence, four experiments in male Sprague–Dawley rats compared the effects of precipitated morphine withdrawal and conditioned morphine withdrawal on the consolidation of object memory and on activation of c‐Fos in the central nucleus of the amygdala (CeA). It was found that immediate, but not 6 h delayed, post sample administration of 3 mg/kg of naltrexone significantly enhanced object memory in rats maintained, or previously maintained, on 10 mg/kg/day of morphine via osmotic minipumps. To establish whether conditioned withdrawal could also alter object memory, a contextual conditioning procedure was employed whereby morphine‐maintained (10 mg/kg/day) animals received naltrexone (3 mg/kg) in a distinctive context (CS+) and vehicle in a separate context (CS−) for 10 days. During conditioning in the CS+, naltrexone suppressed locomotor activity, caused a rapid body weight loss and increased frequency of wet dog shakes. Interestingly, confinement to this CS+ immediately, but not 6 h, after the sample phase, also enhanced object memory. Finally, posttraining naltrexone and exposure to the CS+ both induced significant expression of c‐Fos in the CeA. Therefore, this study reports for the first time that both acute precipitated withdrawal and conditioned withdrawal can facilitate memory consolidation, possibly through a common neural pathway that involves the central amygdala.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%