Double dissociation of perirhinal nicotinic acetylcholine receptors and dopamine D2 receptors in modulation of object memory consolidation by nicotine, cocaine and their conditioned stimuli

Wolter, Michael; Lapointe, Thomas; Baidoo, Nana; Mitchnick, Krista A.; Wideman, Cassidy E.; Winters, Boyer D.; Leri, Francesco

doi:10.1016/j.euroneuro.2023.04.002

Cited by 2 publications

(1 citation statement)

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“…Acute cocaine use has been shown to increase dopamine and 5-HT [94]. Cocaine has been found to enhance memory consolidation by D2R agonism, which may contribute to cocaine conditioning [95]. Cocaine also induces tPA mRNA in the perirhinal cortex.…”

Section: Discussionmentioning

confidence: 99%

Exercise Influences the Brain’s Metabolic Response to Chronic Cocaine Exposure in Male Rats

Powell,

Hanna,

Sajjad

et al. 2024

JPM

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Cocaine use is associated with negative health outcomes: cocaine use disorders, speedballing, and overdose deaths. Currently, treatments for cocaine use disorders and overdose are non-existent when compared to opioid use disorders, and current standard cocaine use disorder treatments have high dropout and recidivism rates. Physical exercise has been shown to attenuate addiction behavior as well as modulate brain activity. This study examined the differential effects of chronic cocaine use between exercised and sedentary rats. The effects of exercise on brain glucose metabolism (BGluM) following chronic cocaine exposure were assessed using Positron Emission Tomography (PET) and [18F]-Fluorodeoxyglucose (FDG). Compared to sedentary animals, exercise decreased metabolism in the SIBF primary somatosensory cortex. Activation occurred in the amygdalopiriform and piriform cortex, trigeminothalamic tract, rhinal and perirhinal cortex, and visual cortex. BGluM changes may help ameliorate various aspects of cocaine abuse and reinstatement. Further investigation is needed into the underlying neuronal circuits involved in BGluM changes and their association with addiction behaviors.

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Section: Discussionmentioning

confidence: 99%