Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists

Wolter, Michael; Lapointe, Thomas; Melanson, Brett; Baidoo, Nana; Francis, Travis; Winters, Boyer D.; Leri, Francesco

doi:10.1007/s00213-021-05884-x

Cited by 9 publications

(8 citation statements)

References 86 publications

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“…Following this period, however, memories become resilient. For example, dihydrokainic acid administration at 0h impaired memory performance, while at 6h had no effect [15]; similarly, sulfur dioxide administration 0h after reactivation, but not 6h, impaired reward memory reconsolidation [19]，while nicotine injection at 0h rather than 6h after sample or reactivation enhanced both memory consolidation and reconsolidation [17,18]. In the present study, we found that UCA injection at 0h rather than 6h after sample or reactivation improves, respectively, memory consolidation and reconsolidation.…”

Section: Discussionsupporting

confidence: 48%

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Urocanic acid enhances memory consolidation and reconsolidation in novel object recognition task

et al. 2021

Biochemical and Biophysical Research Communications

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Section: Discussionsupporting

confidence: 48%

“…Evidence suggests that memory changes from an initial unstable state to a stable state following acquisition or reactivation, this stabilization occuring in a critical time window, usually 1-6h [15,[17][18][19]. During this window, memory can be shifted, modified, strengthened or deleted.…”

Section: Discussionmentioning

confidence: 99%

Urocanic acid enhances memory consolidation and reconsolidation in novel object recognition task

et al. 2021

Biochemical and Biophysical Research Communications

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“…Such interpretation is consistent with measures of DA concentrations in the NAc indicating that both passive 18,49,50 and self-administered 51 morphine/heroin elevate DA, but that this DA response is lost after repeated heroin self-administration 18 . Because DA plays key role in memory consolidation [52][53][54] , and our laboratory has demonstrated that DA antagonists can block the facilitation of memory consolidation by cocaine and nicotine when passively administered 55 , it is possible that self-administered heroin in well trained rats can no longer modulate memory consolidation. Clearly, it will be important to directly explore whether the memory enhancing function of post-sample passive heroin is dependent on DA activity.…”

Section: Discussionmentioning

confidence: 99%

The effects of passive and active administration of heroin, and associated conditioned stimuli, on consolidation of object memory

Francis

Wolter

Leri

2022

Sci Rep

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Mode of administration (i.e., active vs passive) could influence the modulatory action that drugs of abuse exert on memory consolidation. Similarly, drug conditioned stimuli modulate memory consolidation and, therefore, acquisition and extinction of this conditioned response could also be influenced by mode of drug administration. Exploring these questions in male Sprague–Dawley rats, Study 1 assessed memory modulation by post-training 0, 0.3 and 1 mg/kg heroin injected subcutaneously in operant chambers (i.e., drug conditioned context). Study 2 asked a similar question but in rats trained to self-administer 0.05 mg/kg/infusion heroin intravenously, as well as in rats that received identical amounts of intravenous heroin but passively, using a yoked design. The period of heroin exposure was followed by repeated drug-free confinement in the conditioned context, and by sessions during which responses on the active lever had no scheduled consequences. Study 2 also included a cue-induced reinstatement session during which lever responses reactivated a light cue previously paired with intravenous heroin infusions. The post-training effects of injected/self-administered/yoked heroin, extinction and reinstatement sessions on memory consolidation were tested using the object location memory task. It was found that post-sample heroin enhanced memory in injected and yoked, but not self-administering, rats. However, post-sample exposure to the heroin cues (i.e., context or/and light cue) modulated memory equally in all groups. Taken together, these data support the conclusion that mode of administration impacts the cognitive consequences of exposure to drugs but not of environmental stimuli linked to their reinforcing effects.

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“…In fact, it is known that a prediction error is generated when there is a discrepancy between what occurs and what is expected [33][34][35] and that the neurobiological correlate of this cognitive response is activation of mesolimbic DA [36][37][38][39] . It is also known that DA plays a key role in memory consolidation [40][41][42] , and our laboratory has demonstrated that DA antagonists can indeed block the facilitation of memory consolidation by cocaine and nicotine when passively administered [43] . Accordingly, it is possible that once drug-taking behaviour becomes well established and the outcome of lever pressing is anticipated by the subject, the experience of engaging in those behaviours and the pharmacological effects of the drug become expected, the dopamine signal is reduced/lost, and the experience can no longer modulate memory consolidation.…”

Section: Discussionmentioning

confidence: 88%

The effects of active and passive intravenous heroin and heroin conditioned stimuli on consolidation of object memory

Francis

Wolter

Leri

2022

Preprint

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Drugs of abuse and their associated conditioned stimuli (CS) modulate memory consolidation, but it is possible that these effects are influenced by the mode of administration (i.e., active vs passive). This study employed a self-administration/yoked design in male Sprague-Dawley rats (N = 36): one group (n = 18) intravenously self-administered infusions of 0.05 mg/kg heroin paired with the activation of a light CS, and a yoked group (n = 18) received an equal number of infusions and light CS presentations independent of their lever responses. Self-administration/yoked training was followed by extinction during which responses on the active lever had no consequences, and by a cue-induced reinstatement session during which active lever responses resulted in the reactivation of the light CS, but no heroin delivery. The post-training effects of self-administered/yoked heroin, extinction and reinstatement sessions on memory consolidation were tested using the object location memory task. It was found that post-sample heroin enhanced object location memory in yoked, but not self-administering rats. However, post-sample extinction and reinstatement sessions equally modulated memory in both groups. Taken together, these data in rats support the perspective that mode of administration impacts the cognitive consequences of exposure to drugs and environmental stimuli linked to their reinforcing effects.

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Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists

Cited by 9 publications

References 86 publications

Urocanic acid enhances memory consolidation and reconsolidation in novel object recognition task

Urocanic acid enhances memory consolidation and reconsolidation in novel object recognition task

The effects of passive and active administration of heroin, and associated conditioned stimuli, on consolidation of object memory

The effects of active and passive intravenous heroin and heroin conditioned stimuli on consolidation of object memory

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