Urocanic acid enhances memory consolidation and reconsolidation in novel object recognition task

Yu, Xiaohua; Mo, Yan-Xin; He, Zhiming; Reilly, James; Tian, Shuo; Shu, Xinhua

doi:10.1016/j.bbrc.2021.09.055

Cited by 6 publications

(1 citation statement)

References 31 publications

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“…The behavioral procedure employed was based on earlier studies [12]. The procedure comprised three phases—sample, reactivation, and the test phase—with a 24 h between each phase (long-term memory).…”

Section: Methodsmentioning

confidence: 99%

The role of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type receptor modulators in object recognition memory reconsolidation

Man

Chang

et al. 2022

NeuroReport

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Objective Numerous studies suggest that the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidtype (AMPA) receptor appears to play a central role in mediating brain functions, such as learning and memory. Trafficking of this receptor is related to different long-term memory processes. This study explores the role of two AMPA receptor (AMPAR) modulators in object recognition memory (ORM) reconsolidation.Methods First, the effects of immediate administration of each drug after memory reactivation were investigated and compared. Then, this drug's efficient time window and its effects without memory reactivation were investigated. ResultsImmediate CX546 administration after reactivation did not affect ORM reconsolidation. In contrast, administration of 10-mg/kg NBQX significantly impaired ORM reconsolidation within a 6-h time window. Importantly, the observed effects were not attributed to the exploratory behavior or locomotor activity of mice. ConclusionThese findings provide new evidence that the AMPA receptor plays an important role in the reconsolidation phase of ORM.

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Section: Methodsmentioning

confidence: 99%