Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields

Premi, Enrico; Benussi, Alberto; Gatta, Antonio La; Visconti, Stefano; Costa, Angelo; Gilberti, Nicola; Cantoni, Valentina; Padovani, Alessandro; Borroni, Barbara; Magoni, Mauro

doi:10.1186/s12868-018-0434-z

Cited by 23 publications

(29 citation statements)

References 31 publications

(29 reference statements)

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“…Energy changes are often used as features to characterize activity that triggers brain signals [28], [33], [34]. Given a raw signal sequence x(t), j layer decomposition is carried out through wavelet packet transformation (WPT or WPD).…”

Section: ) Recmentioning

confidence: 99%

Detection of Acute Tonic Cold Pain From Microwave Transcranial Transmission Signals Obtained via the Microwave Scattering Approach

et al. 2019

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To investigate the feasibility of detecting acute tonic cold pain (CP) perception from recordable microwave transcranial transmission (MTT) signals by using machine learning techniques. CP and no-pain (NP) MTT signals collected from 15 young subjects are analyzed in the wavelet packet transformation (WPT) and variational mode decomposition (VMD) domains. In addition, features such as relative energy change, refined composite multiscale dispersion entropy, refined composite multiscale fuzzy entropy, and autoregressive model coefficients are extracted in the WPD, VMD, VMD-WPD, and WPD-VMD domains. Simultaneously, support vector machine (SVM) is selected as the classifier, and feature indexes are input into the classifier by using the 10-fold cross validation method to obtain the best training and test datasets. Principal component analysis is used to reduce the feature dimensions of the training and test datasets and to improve classification accuracy. Then, the test dataset is imported into the trained classifier for the calculation and evaluation of the model's classification performance. In the validation of the SVM classifier, feature extraction in the WPD-VMD domain is the best pain detection algorithm. It provides high values of sensitivity (91.30%), specificity (90.47%), positive predictive value (91.30%), accuracy (90.90%), and area under curve (0.806). The microwave scattering technique can be used as a direct, objective, and experimentally stable method to detect acute CP perception, this approach has a high application prospect for clinical real-time diagnosis.

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Section: ) Recmentioning

confidence: 99%

Detection of Acute Tonic Cold Pain From Microwave Transcranial Transmission Signals Obtained via the Microwave Scattering Approach

et al. 2019

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“…Diamagnetic therapy movement of liquids protocol may favor fluid drainage, tissue stimulation, nutrient and metabolite transport, cellular homeostasis. These effects are possible according to diamagnetic therapy action on water and intracellular/extracellular environment [ 46 , 59 , 60 ]. Our study evidenced an important benefit in patients.…”

Section: Discussionmentioning

confidence: 99%

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field

et al. 2022

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High-intensity, low-frequency magnetic fields (MFs) have been widely used in the treatment of diseases and in drug delivery, even though they could induce structural changes in pharmacological molecules. Morphological changes in ketoprofen and KiOil were investigated through Fourier-transform infrared spectroscopy (FT-IR). Unsupervised principal component analysis was carried out for data clustering. Clinical validation on 22 patients with lower back pain was managed using diamagnetic therapy plus topical ketoprofen or KiOil. The Numerical Rating Scale (NRS) and Short-Form Health Survey 36 (SF-36) were used to evaluate clinical and functional response. Ketoprofen showed clear clustering among samples exposed to MF (4000–650 cm−1), and in the narrow frequency band (1675–1475 cm−1), results evidenced structural changes which involved other excipients than ketoprofen. KiOil has evidenced structural modifications in the subcomponents of the formulation. Clinical treatment with ketoprofen showed an average NRS of 7.77 ± 2.25 before and an average NRS of 2.45 ± 2.38 after MF treatment. There was a statistically significant reduction in NRS (p = 0.003) and in SF-36 (p < 0.005). Patients treated with KiOil showed an average NRS of 7.59 ± 2.49 before treatment and an average NRS of 1.90 ± 2.26 after treatment (p < 0.005). SF-36 showed statistical significance for all items except limitations due to emotional problems. A high-intensity pulsed magnetic field is an adjunct to topical treatment in patients with localized pain, and the effect of MF does not evidence significant effects on the molecules.

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“…As mentioned, other electromagnetic stimulation methods may also be useful versus AD, but they would operate through different pathways than REMF. TMS, for example, induces an electric current that depolarizes neurons and trigger action potentials using a field strength of about 1 tesla (T), it allows stimulating the brain areas located up to 2 cm from its surface 100 . REMFS may not depolarize neurons.…”

Section: Discussionmentioning

confidence: 99%

Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures

Perez

Maloney

Chopra

et al. 2021

Sci Rep

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Late Onset Alzheimer’s Disease is the most common cause of dementia, characterized by extracellular deposition of plaques primarily of amyloid-β (Aβ) peptide and tangles primarily of hyperphosphorylated tau protein. We present data to suggest a noninvasive strategy to decrease potentially toxic Aβ levels, using repeated electromagnetic field stimulation (REMFS) in primary human brain (PHB) cultures. We examined effects of REMFS on Aβ levels (Aβ40 and Aβ42, that are 40 or 42 amino acid residues in length, respectively) in PHB cultures at different frequencies, powers, and specific absorption rates (SAR). PHB cultures at day in vitro 7 (DIV7) treated with 64 MHz, and 1 hour daily for 14 days (DIV 21) had significantly reduced levels of secreted Aβ40 (p = 001) and Aβ42 (p = 0.029) peptides, compared to untreated cultures. PHB cultures (DIV7) treated at 64 MHz, for 1 or 2 hour during 14 days also produced significantly lower Aβ levels. PHB cultures (DIV28) treated with 64 MHz 1 hour/day during 4 or 8 days produced a similar significant reduction in Aβ40 levels. 0.4 W/kg was the minimum SAR required to produce a biological effect. Exposure did not result in cellular toxicity nor significant changes in secreted Aβ precursor protein-α (sAPPα) levels, suggesting the decrease in Aβ did not likely result from redirection toward the α-secretase pathway. EMF frequency and power used in our work is utilized in human magnetic resonance imaging (MRI, thus suggesting REMFS can be further developed in clinical settings to modulate Aβ deposition.

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Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields

Cited by 23 publications

References 31 publications

Detection of Acute Tonic Cold Pain From Microwave Transcranial Transmission Signals Obtained via the Microwave Scattering Approach

Detection of Acute Tonic Cold Pain From Microwave Transcranial Transmission Signals Obtained via the Microwave Scattering Approach

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field

Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures

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