Modulation of gut microbiota by polyphenols from adlay (Coix lacryma-jobiL. var.ma-yuenStapf.) in rats fed a high-cholesterol diet

Abstract

This study aimed to evaluate the beneficial effects of polyphenol extract of adlay (Coix lacryma-jobi L. var. ma-yuen Stapf.) (PEA) on gut microbiota in rats fed a high-cholesterol diet (HCD). Rats were fed HCD containing 1% cholesterol (w/w), with or without a daily intragastric supplement of 200 mg/kg body weight PEA. Results showed that PEA significantly ameliorated increases in serum cholesterol and low-density lipoprotein cholesterol values and significantly restored high-density lipoprotein cholesterol values. The HCD-induced imbalance of gut microflora was modulated by the consumption of PEA. Most bacterial strains influenced by PEA are related to host lipid metabolism. The abundances of one Erysipelotrichales strains and two Clostridia strains were lower in the PEA group than in the control. Phenolic compounds in PEA were identified by HPLC. The findings indicate that PEA may be a useful dietary supplement in the treatment of elevated cholesterol levels and the imbalanced gut microbial ecology.

Fiber and phenolic compounds contribution to the hepatoprotective effects of mango diets in rats fed high cholesterol/sodium cholate

“…For example, Guo, Shu, and Yang () determined that green tea ( Camellia sinensis L.) fiber significantly decrease hepatic cholesterol concentration, due to its cholesterol‐ and bile‐binding ability (particularly at intestinal pH values), which promoted fecal cholesterol excretion. On the other hand, Wang et al () administered 200 mg of polyphenols from adlay ( Coix lacryma‐jobi L. var. ma‐yuen Stapf.)…”

Beneficial Effects of Dietary Polyphenols on High-Fat Diet-Induced Obesity Linking with Modulation of Gut Microbiota

“…Sinapic acid is a derivative of cinnamic acid and extensively exists in edible plants and fruits. It possessed efficient anti-inflammatory and antioxidative properties. , Ferulic acid, p -coumaric acid, and sinapic acid, mainly composing the polyphenols from adlay, improved the imbalance of gut microbiota and lowered the relative abundance of strains from Erysipelotrichales and Clostridia in high-cholesterol fed-rats …”

“…183,184 Ferulic acid, p-coumaric acid, and sinapic acid, mainly composing the polyphenols from adlay, improved the imbalance of gut microbiota and lowered the relative abundance of strains from Erysipelotrichales and Clostridia in high-cholesterol fed-rats. 185 Hydroxybenzoic Acids. Hydroxybenzoic acid derivatives mainly consist of gallic acid, vanillic acid, and protocatechuic acid.…”

Modelling hypercholesterolaemia in rats using high cholesterol diet

“…Of the 208 articles initially analysed, 33 met the inclusion criteria and were included in the present study. It is noticable that the most commonly used protocol for inducing hypercholesterolaemia was the addition of 1% cholesterol to animal diets which appears in 12.1% of the analysed articles, [14][15][16][17] followed by the addition of 2% cholesterol 18,19 and 2% cholesterol + 0.5% cholic acid, 20,21 Both of the latter protocols were used by 6% of the analysed articles. Only one study used each of the other listed protocols.…”