Modulation of Gut Microbiota by Fucoxanthin During Alleviation of Obesity in High-Fat Diet-Fed Mice

Sun, Xiaowen; Zhao, Hailong; Liu, Zonglin; Sun, Xun; Zhang, Dandan; Wang, Shuhui; Xu, Ying; Zhang, Guofang; Wang, Dongfeng

doi:10.1021/acs.jafc.0c01467

Cited by 78 publications

(57 citation statements)

References 50 publications

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“…All data presented herein were obtained from refs. [44,54,55,70,72,74,75,78,88,95,96,98,[102][103][104][105][106][107][108][109][110][111]116,[119][120][121][124][125][126][127][128][129][130]132,[134][135][136][137][140][141][142][143][144][147][148][149][150][151][152][153][154]…”

Section: Resultsmentioning

confidence: 99%

“…All data presented herein were obtained from refs. [44,54,55,70,72,74,75,78,88,95,96,98,102–111,116,119–121,124–130,132,134–137,140–144,147–156,158,159,161,163–171,173–176...…”

Section: Diet Composition and Exposure Timementioning

confidence: 99%

“…All data presented herein were obtained from refs. [70,72,74,77,78,88,95,96,98,104,105,107,109–112,114–128,130,132,133,135–142,144–146,148,150,151,153,154,157,159,161–168,174,176–184,187,188,190,191,194,196–198,200–204,206,208–212,215,217,219–226,229,230,232–235,237,239–242,244,250–253,257,258,263,264,266–268,270–276,278,285,287–290,292,295,296,298–301,303,304,308–310,314,316,317,319,321,322,324,325,329,331–342].…”

Section: Diet Composition and Exposure Timementioning

confidence: 99%

See 2 more Smart Citations

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Leonardi

Gosmann

Zimmer

2020

Molecular Nutrition Food Res

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Standardized animal models represent one of the most valuable tools available to understand the mechanism underlying the metabolic syndrome (MetS) and to seek for new therapeutic strategies. However, there is considerable variability in the studies conducted with this essential purpose. This review presents an updated discussion of the most recent studies using diverse experimental conditions to induce MetS in rodents with unbalanced diets, discusses the key findings in metabolic outcomes, and critically evaluates what we have been learned from them and how to advance in the field. The study includes scientific reports sourced from the Web of Science and PubMed databases, published between January 2013 and June 2020, which used hypercaloric diets to induce metabolic disorders, and address the impact of the diet on metabolic parameters. The collected data are used as support to discuss variables such as sex, species, and age of the animals, the most favorable type of diet, and the ideal diet length to generate metabolic changes. The experimental characteristics propose herein improve the performance of a preclinical model that resembles the human MetS and will guide researchers to investigate new therapeutic alternatives with confidence and higher translational validity.

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Section: Resultsmentioning

confidence: 99%

Section: Diet Composition and Exposure Timementioning

confidence: 99%

Section: Diet Composition and Exposure Timementioning

confidence: 99%

See 1 more Smart Citation

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Leonardi

Gosmann

Zimmer

2020

Molecular Nutrition Food Res

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“…Sun et al showed that the administration of a high-fat diet containing Fx (1 mg Fx/g diet) decreased the rate of Lachnospiraceae and Erysipelotrichaceae and increased the rates of Lactobacillus , Lactococcus , Bifidobacterium and several butyrate-producing bacteria in feces of an obese murine C57BL/6J model, along with decreasing serum levels of TNF-α and IL-6. In addition, the gut bacterial taxa were significantly associated with obesity phenotypes and the degree of inflammation [ 135 ]. Another group reported that Fx administration (125 mg/kg bw) for 4 weeks reduced BW and changed the cecal and fecal microbiota in BALB/c mice given a normal or a high-fat diet.…”

Section: Cancer Preventive Effect Of Brown Algae and Fx In Crc Model Animalsmentioning

confidence: 99%

Fucoxanthin and Colorectal Cancer Prevention

Terasaki

Kubota

Kojima

et al. 2021

Cancers

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Colorectal cancer (CRC), which ranks among the top 10 most prevalent cancers, can obtain a good outcome with appropriate surgery and/or chemotherapy. However, the global numbers of both new cancer cases and death from CRC are expected to increase up to 2030. Diet-induced lifestyle modification is suggested to be effective in reducing the risk of human CRC; therefore, interventional studies using diets or diet-derived compounds have been conducted to explore the prevention of CRC. Fucoxanthin (Fx), a dietary carotenoid, is predominantly contained in edible brown algae, such as Undaria pinnatifida (wakame) and Himanthalia elongata (Sea spaghetti), which are consumed particularly frequently in Asian countries but also in some Western countries. Fx is responsible for a majority of the anticancer effects exerted by the lipophilic bioactive compounds in those algae. Interventional human trials have shown that Fx and brown algae mitigate certain risk factors for CRC; however, the direct mechanisms underlying the anti-CRC properties of Fx remain elusive. Fx and its deacetylated type “fucoxanthinol” (FxOH) have been reported to exert potential anticancer effects in preclinical cancer models through the suppression of many cancer-related signal pathways and the tumor microenvironment or alteration of the gut microbiota. We herein review the most recent studies on Fx as a potential candidate drug for CRC prevention.

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“…Fucoxanthin is a xanthophyll exhibiting several health benefits. This compound has remarkable biological properties for human health [109], such as anti-inflammatory activity [108][109][110][111][112][113][114][115], hepatoprotective effect [12,98,[116][117][118], cardioprotective activity [119][120][121], anticancer [26,116,119,[122][123][124][125][126][127][128][129][130][131], antidiabetic [75,[132][133][134], antiobesity [135][136][137][138][139], antioxidant [65,131,[140][141][142][143][144][145][146], skin protective effect…”

Section: Fucoxanthin and Their Biological Activitiesmentioning

confidence: 99%

Fucoxanthin, A Xanthophyll from Macro- and Microalgae: Extraction Techniques, Bioactivities and Their Potential Application in Nutra- and Cosmeceutical Industries

Noviendri

Fithriani

Hasrini³

2021

E3S Web Conf.

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Some works of literature reported that fucoxanthin has diverse potential benefits for human health. Thus, this review would explain the sources of fucoxanthin, extraction techniques, bioactivities, and its potential application in Nutra- and cosmeceutical industries. Brown algae, such as Padina australis, Undaria pinnatifida; and the microalgae, such as Chaetoceros gracilis, Phaeodactylum tricornutum were sources of fucoxanthin. Then, the chemical structure of this xanthophyll is unique and that confers its biological activities. And then, the extraction process of fucoxanthin from macro- and microalgae is more safe, accessible, and economic, although this xanthophyll can be synthesized chemically. Generally, there are two techniques for the extraction of fucoxanthin, namely liquid solvent (conventional), and supercritical carbon dioxide (non-conventional) extractions. Furthermore, there are some bioactivities of fucoxanthin, including its activities of anticancer, antidiabetic, antiobesity, antioxidant; protective effects of skin, bone, and eyes. Based on in vivo assay of the animal, it has no adverse effects of fucoxanthin supplementation. Therefore, this xanthophyll might be applied in both the Nutra- and cosmeceutical industries. In the future, fucoxanthin and its derivatives would be important for human health, contributing to the beauty industry, and playing an important in the prevention of cancer and the disease related to lifestyle.

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Modulation of Gut Microbiota by Fucoxanthin During Alleviation of Obesity in High-Fat Diet-Fed Mice

Cited by 78 publications

References 50 publications

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Fucoxanthin and Colorectal Cancer Prevention

Fucoxanthin, A Xanthophyll from Macro- and Microalgae: Extraction Techniques, Bioactivities and Their Potential Application in Nutra- and Cosmeceutical Industries

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