Modulation of Fenthion-Induced Oxidative Effects by BSO in the Liver of<i>Cyprinus carpio</i>L

Üner, Nevin; Sevgiler, Yusuf; Piner, Petek; Durmaz, Hülya

doi:10.1080/01480540802171233

Cited by 8 publications

(5 citation statements)

References 32 publications

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“…GSH and its related enzymes also play a primary role in protecting against oxidative stress-induced cellular damage (Hung et al, 2006). In addition, GSH works as an electron donor for GSH-px to protect cells from oxidative stress, thereby an excessive amount of oxidized GSH (GSSG) is generated in this process and GSSG is recycled to GSH by the action of GSH-red (Uner et al, 2008). Our results showed that DLWE pretreatment suppressed oxidative stress by enhancing GSH and antioxidative enzyme activities.…”

Section: Status Of Oxidative Stress and Antioxidative Enzyme Activitiesmentioning

confidence: 74%

Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in sprague‐dawley rats

Park

Suk

Youn

et al. 2010

Phytotherapy Research

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The protective effects of common dandelion leaf water extract (DLWE) were investigated by carbon tetrachloride (CCl4) induced hepatitis in Sprague-Dawley rats. The animals were divided into five groups: normal control, DLWE control, CCl4 control, and two DLWE groups (0.5 and 2 g/kg bw). After 1 week of administering corresponding vehicle or DLWE, a single dose of CCl4 (50% CCl4/olive oil; 0.5 mL/kg bw) was administered 24 h before killing in order to produce acute liver injury. The DLWE treatment significantly decreased CCl4-induced hepatic enzyme activities (AST, ALT and LDH) in a dose dependent manner. Also, the obstructed release of TG and cholesterol into the serum was repaired by DLWE administration. Hepatic lipid peroxidation was elevated while the GSH content and antioxidative enzyme activities were reduced in the liver as a result of CCl4 administration, which were counteracted by DLWE administration. Furthermore, the hepatocytotoxic effects of CCl4 were confirmed by significantly elevated Fas and TNF-α mRNA expression levels, but DLWE down-regulated these expressions to the levels of the normal control. Highly up-regulated cytochrome P450 2E1 was also lowered significantly in the DLWE groups. These results indicate that DLWE has a protective effect against CCl4-induced hepatic damage with at least part of its effect being attributable to the attenuation of oxidative stress and inflammatory processes resulting from cytochrome P450 activation by CCl4.

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Section: Status Of Oxidative Stress and Antioxidative Enzyme Activitiesmentioning

confidence: 74%

Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in sprague‐dawley rats

Park

Suk

Youn

et al. 2010

Phytotherapy Research

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“…Any change in the G6PD, (reduced glutathione) GSH, and glutathione S-transferase (GST) can cause LPO and tissue damage. 11,12,64,80,88,93,[123][124][125][126][127][128][129][130][131][132][133] It should be noticed that antioxidative defense mechanisms and even LPO in various tissues varies according to the type of pesticide and the doses used. 87 Oxidative stress leads to DNA damage and affects genes encoding cytochrome P450s and UDP-glucuronosyl/ UDP-glucosyltransferases that are involved in body metabolism.…”

Section: Brainmentioning

confidence: 99%

“…195 Application of buthionine sulfoximine reversed inhibitory effect of fenthion on SOD and GPx, whereas GST was elevated. 129 Recently, it was found that essential oil from Satureja khuzestanica improves malathion-induced AChE inhibition and hepatic mitochondrial GP and PEPCK activities, by its antioxidant potential. 81 Protective effects of alpha-tocopherol and N -acetyl-cysteine (NAC) on diazinon-induced oxidative stress and AChE inhibition in rats have been also reported.…”

Section: Blood Glucose Alteration In Clinical and Animal Studiesmentioning

confidence: 99%

Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates

2010

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Pesticides, including organophosphate (OP), organochlorine (OC), and carbamate (CB) compounds, are widely used in agricultural and indoor purposes. OP and CB act as acetyl cholinesterase (AChE) inhibitors that affect lots of organs such as peripheral and central nervous systems, muscles, liver, pancreas, and brain, whereas OC are neurotoxic involved in alteration of ion channels. There are several reports about metabolic disorders, hyperglycemia, and also oxidative stress in acute and chronic exposures to pesticides that are linked with diabetes and other metabolic disorders. In this respect, there are several in vitro and in vivo but few clinical studies about mechanism underlying these effects. Bibliographic databases were searched for the years 1963–2010 and resulted in 1652 articles. After elimination of duplicates or irrelevant papers, 204 papers were included and reviewed. Results indicated that OP and CB impair the enzymatic pathways involved in metabolism of carbohydrates, fats and protein within cytoplasm, mitochondria, and proxisomes. It is believed that OP and CB show this effect through inhibition of AChE or affecting target organs directly. OC mostly affect lipid metabolism in the adipose tissues and change glucose pathway in other cells. As a shared mechanism, all OP, CB and OC induce cellular oxidative stress via affecting mitochondrial function and therefore disrupt neuronal and hormonal status of the body. Establishing proper epidemiological studies to explore exact relationships between exposure levels to these pesticides and rate of resulted metabolic disorders in human will be helpful.

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“…OPs are oxidants and impair enzymatic antioxidant defences, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione S-transferase (GST) (23,34,44,(114)(115)(116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128)(129). Malathion, methyl parathion, and parathion in HepG2 cell lines, as well as chlorpyrifos, methidathion, chlorfenvinphos, and dimethoate in rat liver and diazinon in fish most probably disrupt membrane lipids through oxidative stress (23,35,61,116,118,(130)(131)(132)(133)(134)(135). Table 1 summarises the key changes in antioxidant defence and oxidative stress biomarkers caused by OPs.…”

Section: Possible Effects Of Ops On Hepatic Oxidative Stress Pathwaysmentioning

confidence: 99%

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Karami‐Mohajeri

Ahmadipour

Rahimi

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Organophosphorus pesticides (OPs) are widely used volatile pesticides that have harmful effects on the liver in acute and chronic exposures. This review article summarises and discusses a wide collection of studies published over the last 40 years reporting on the effects of OPs on the liver, in an attempt to propose general mechanisms of OP hepatotoxicity and possible treatment. Several key biological processes have been reported as involved in OP-induced hepatotoxicity such as disturbances in the antioxidant defence system, oxidative stress, apoptosis, and mitochondrial and microsomal metabolism. Most studies show that antioxidants can attenuate oxidative stress and the consequent changes in liver function. However, few studies have examined the relationship between OP structures and the severity and mechanism of their action. We hope that future in vitro, in vivo, and clinical trials will answer the remaining questions about the mechanisms of OP hepatotoxicity and its management.

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Modulation of Fenthion-Induced Oxidative Effects by BSO in the Liver ofCyprinus carpioL

Cited by 8 publications

References 32 publications

Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in sprague‐dawley rats

Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in sprague‐dawley rats

Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

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