Modulation of Chemical Carcinogenesis by Hormones

Hilf, Russell

doi:10.1016/b978-0-12-452806-2.50010-8

Cited by 2 publications

(1 citation statement)

References 115 publications

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“…A number of reports from work with mammals suggest possibilities, but none as yet provides us with a satisfactory hypothesis. Thus, a study made on Sprague-Dawley rats showed that a single injection of DMBA was highly efficient in inducing mammary cancer (Hilf, 1979). However, other work demonstrated that in the susceptible mammary tissue, there was persistent binding of the carcinogen to DNA, whilst in less susceptible tissues such as liver, spleen and kidney, the amount of DMBA bound to cellular protein exceeded that bound to DNA.…”

Section: Discussionmentioning

confidence: 99%

Effects of polycyclic aromatic hydrocarbons on the proliferation of ectopic thyroid tissue in Poecilia formosa, the Amazon molly*

Woodhead

Setlow

Pond

1982

Journal of Fish Biology

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A single intraperitoneal injection of any one of several polycyclic aromatic hydrocarbons given to young Amazon mollies induces massive enlargement of the spleen. This enlargement is the result of splenic tissue being partially or wholly replaced by proliferating thyroid tissue. The pharyngeal thyroid gland is stimulated but to a lesser degree. No exuberant thyroid tissue is found at any other extrapharyngeal site. We discuss the possible causes of this finding.

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Section: Discussionmentioning

confidence: 99%

Effects of polycyclic aromatic hydrocarbons on the proliferation of ectopic thyroid tissue in Poecilia formosa, the Amazon molly*

Woodhead

Setlow

Pond

1982

Journal of Fish Biology

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Effects of carcinogen and/or mutagen on normal and gonadotropin‐primed ovaries of mice

1981

Intl Journal of Cancer

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The influence of pregnant mare serum gonadotropin (PSGM) on the induction of ovarian tumors by carcinogen(DMBA) and/or mutagens (EMS and BMS) has been studied in Swiss albino mice. Priming of the ovaries of 6-week-old mice with PMSG (50 IU/mouse) 24 h before intragastric intubation of DMBA (5 mg/mouse) resulted in a significant increase in ovarian tumors when harvested 6 months after the treatment. A similar experiment done on 8-week-old mice yielded confirmatory results. Mutagens (EMS and BMS) failed, at given dose levels (200 mg/kg and 300 mg/kg body weight), to induce tumors in normal as well as PMSG-primed ovaries. Pretreatment of animals with PMSG-enhanced DMBA-induced oocyte depletion and also increased the DMBA-3H activity in the ovaries. The augmentation of DMBA-induced tumors in PMSG-primed ovaries could be due to increased uptake of DMBA and increased depletion of oocytes. It is also possible that PMSG-primed ovaries provided more proliferating granulosa cells (and macromolecules) for the interaction of DMBA (or its metabolites) and thereby increased the chances of cell transformation in the ovaries.

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Modulation of Chemical Carcinogenesis by Hormones

Cited by 2 publications

References 115 publications

Effects of polycyclic aromatic hydrocarbons on the proliferation of ectopic thyroid tissue in Poecilia formosa, the Amazon molly*

Effects of polycyclic aromatic hydrocarbons on the proliferation of ectopic thyroid tissue in Poecilia formosa, the Amazon molly*

Effects of carcinogen and/or mutagen on normal and gonadotropin‐primed ovaries of mice

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