Effects of polycyclic aromatic hydrocarbons on the proliferation of ectopic thyroid tissue in <i>Poecilia formosa</i>, the Amazon molly*

Woodhead, Avril D.; Setlow, R. B.; Pond, Virginia

doi:10.1111/j.1095-8649.1982.tb03938.x

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…A single i.p. injection of any one of several PAHs into Amazon mollies ( Poecilia formosa ) stimulated proliferation of both pharyngeal and ectopic thyroid tissue in the spleen [62]. The water‐soluble components of petroleum products are the only other aromatic hydrocarbons to receive attention as potential thyroid disruptors.…”

Section: Studies Of Thyroid Disruptionmentioning

confidence: 99%

Contaminant effects on the teleost fish thyroid

Brown

Adams

Cyr

et al. 2004

Enviro Toxic and Chemistry

226

139

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Abstract-Numerous environmentally relevant chemicals, including polychlorinated hydrocarbons, polycyclic aromatic hydrocarbons, organochlorine pesticides, chlorinated paraffins, organophosphorous pesticides, carbamate pesticides, cyanide compounds, methyl bromide, phenols, ammonia, metals, acid loads, sex steroids, and pharmaceuticals, exert acute or chronic effects on the thyroid cascade in the approximately 40 teleost fish species tested to date. Thyroid endpoints, therefore, serve as biomarkers of exposure to environmental pollutants. However, the mechanisms underlying thyroid changes and their physiological consequences are poorly understood because the thyroid cascade may respond indirectly and it has considerable capacity to compensate for abuses that otherwise would disrupt thyroid hormone homeostasis. Indeed, a xenobiotic-induced change in fish thyroid function has yet to be conclusively causally linked to decreased fitness or survival. Other complications in interpretation arise from the diversity of test conditions employed and the often indiscriminate use of numerous thyroid endpoints. Future work should be directed toward standardizing test conditions and thyroid endpoints and investigating causal links between thyroid changes and fish growth, reproduction, and development. Development may be particularly susceptible to thyroid disruption, and thyroid endpoints appropriate for early life stages need to be applied.

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Section: Studies Of Thyroid Disruptionmentioning

confidence: 99%

Contaminant effects on the teleost fish thyroid

Brown

Adams

Cyr

et al. 2004

Enviro Toxic and Chemistry

226

139

View full text Add to dashboard Cite

show abstract

“…Histological examination showed that there had been a proliferation of the pharyngeal thyroid gland and that much of the splenic tissue had been replaced by thyroid follicles and cells (Woodhead et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

“…During experiments to compare the carcinogenicity of several polycyclic aromatic hydrocarbons (PAHs) in the Amazon molly, Poecilaformosa, it was observed that groups of fish given the compounds by intraperitoneal injection (ip) developed enlarged spleens, seen at post-mortem some 9 months' later. Histological examination showed that there had been a proliferation of the pharyngeal thyroid gland and that much of the splenic tissue had been replaced by thyroid follicles and cells (Woodhead et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

“…Firstly, cells from the proliferating thyroid tissue in the pharynx may have moved there, either by active migration or by passive transport, by the blood or the lymphatic systems. An alternative suggestion, was that there are already present in the spleen primordial thyroid cells which were stimulated to differentiate in the presence of PAHs; neither idea was without its drawbacks (Woodhead et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

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The pattern of distribution of dimethylbenz(a)anthracene in the Amazon molly, Poecilia formosa (Girard), after intraperitoneal injection*

Woodhead

Bornbusch

1983

Journal of Fish Biology

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The present paper describes the distribution and accumulation of labelled dimethylbenz (a)anthracene (DMBA) in the Amazon molly after intraperitoneal injection. The study was made to see whether there was preferential accumulation of the compound in the spleen; the findings showed that this was not the case. Two hours after injection, DMBA was present throughout the body, except in the brain and the ovary. There was enhanced deposition at four sites, in the macrophages of the atrium of the heart and the peritoneum, the liver and the exocrine pancreas. DMBA was taken up by reticuloendothelial macrophages for 78 h after injection, then it was lost. The accumulation and disappearance of radioactive label seen in the liver and pancreatic cells probably represented the pattern of metabolism of the compound. By 400 h after injection there was little DMBA remaining. Label accumulated in the ameloblasts, which secrete the enamel capping of the teeth.

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Increased Thyroid Hormone Levels in Tree Swallows (Tachycineta bicolor) on Reclaimed Wetlands of the Athabasca Oil Sands

Gentes

McNabb

Waldner

et al. 2007

Arch Environ Contam Toxicol

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The oil sands of Alberta, Canada are one of the world's largest reserves of crude oil. Oil sands mining companies are now investigating the ecological impacts of reclamation strategies in which wetlands are used for the bioremediation of waste materials. To examine the endocrine disrupting potential of chemicals in Oil Sands Process Materials (OSPM), thyroid hormone concentrations were measured in plasma and thyroid glands of nestling tree swallows (Tachycineta bicolor) from wetlands partly filled with mine tailings. Plasma triiodothyronine (T(3)) concentrations and thyroxine (T(4)) content within thyroid glands were elevated in nestlings from OSPM sites compared to those from the reference site. Results suggested enhanced hormone synthesis by the thyroid glands independently of activation of the pituitary-thyroid axis, as well as increased deiodination of T(4) into T(3) in peripheral tissues. This might have resulted from exposure to oil sands associated chemicals such as polycyclic aromatic hydrocarbons and from environmental factors such as food availability. Modulation of thyroid function might have negative effects on metabolism, behavior, feather development, and molt, which could compromise postfledging survival.

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Effects of polycyclic aromatic hydrocarbons on the proliferation of ectopic thyroid tissue in Poecilia formosa, the Amazon molly*

Cited by 7 publications

References 10 publications

Contaminant effects on the teleost fish thyroid

Contaminant effects on the teleost fish thyroid

The pattern of distribution of dimethylbenz(a)anthracene in the Amazon molly, Poecilia formosa (Girard), after intraperitoneal injection*

Increased Thyroid Hormone Levels in Tree Swallows (Tachycineta bicolor) on Reclaimed Wetlands of the Athabasca Oil Sands

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