Modulation of cell adhesion to conductive polymers

Malmström, Jenny; Hackett, Alissa J.; Feisst, Vaughan; Sejdic, Jadranka Travas

doi:10.1504/ijnt.2017.082470

Cited by 5 publications

(5 citation statements)

References 54 publications

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“…These effects were useful in controlling fouling by serum proteins, tuning the surface from fouling to completely antifouling, depending on the copolymer brush composition of di(ethylene glycol) methyl ether methacrylate (DEGMMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMMA) grafted onto PEDOT. This approach was expanded into the adhesion of fibroblast cells onto such surfaces, where changing the brush composition and incorporation of the cell adhesion RGD peptide converted the non-cell-adhesive surface into cell-adhesive . Other types of polymer brushes, such as poly(acrylic acid) (PAA), grafted from PEDOT, showed responsiveness to pH (as shown in Figure ), where the collapse of the brushes upon changing the acidity, in turn, controlled the surface electrochemical activity.…”

Section: Grafting From Conjugated Polymers Deposited On Surfaces For ...mentioning

confidence: 97%

“…As previously mentioned, PEGMMA and DEGMMA copolymerized side chains grafted from a PEDOT surface showed dynamic switching of their conformation induced by the changes in temperature and salt concentration; which are dependent on the brush copolymer composition . Certain compositions of these brushes afforded protein antifouling from a serum solution and modulated fibroblast cell adhesion . On the other hand, multifunctional and photoluminescent PThP- graft -PEGMMAs are water-soluble and thermoresponsive, due to additional grafting of PnPropOx, providing a water-based optical temperature indicator …”

Section: Grafting Of Conjugated Polymers In Solution For Physicochemi...mentioning

confidence: 99%

“…This approach was expanded into the adhesion of fibroblast cells onto such surfaces, where changing the brush composition and incorporation of the cell adhesion RGD peptide converted the non-celladhesive surface into cell-adhesive. 15 Other types of polymer brushes, such as poly(acrylic acid) (PAA), grafted from PEDOT, showed responsiveness to pH (as shown in Figure 1), where the collapse of the brushes upon changing the acidity, in turn, controlled the surface electrochemical activity. As a result, PAA grafted CP films showed preserved and even enhanced electroactivity.…”

Section: Grafting From Conjugated Polymers Deposited On Surfaces For ...mentioning

confidence: 99%

“…22 Certain compositions of these brushes afforded protein antifouling from a serum solution and modulated fibroblast cell adhesion. 15 On the other hand, multifunctional and photoluminescent PThP-graf t-PEGMMAs are water-soluble and thermoresponsive, due to additional grafting of PnPropOx, providing a water-based optical temperature indicator. 45 CPs are widely used in biosensing applications.…”

Section: Applicationsmentioning

confidence: 99%

“…The choice of side chain polymers governs the functionality to be added. For instance, grafting of biomolecules, such as cell adhesion peptides and DNA, renders CPs cell-adhesive or for use as sensing elements, while grafting of poly(acrylic acid), poly( n -butyl acrylate), or poly(acrylate urethane) provides stimuli-responsiveness (pH, for instance) (Adapted with permission from ref . Copyright 2013 American Chemical Society), dry adhesion (Adapted from ref .…”

Section: Introductionmentioning

confidence: 99%

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Molecular Approach to Conjugated Polymers with Biomimetic Properties

et al. 2018

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The field of bioelectronics involves the fascinating interplay between biology and human-made electronics. Applications such as tissue engineering, biosensing, drug delivery, and wearable electronics require biomimetic materials that can translate the physiological and chemical processes of biological systems, such as organs, tissues. and cells, into electrical signals and vice versa. However, the difference in the physical nature of soft biological elements and rigid electronic materials calls for new conductive or electroactive materials with added biomimetic properties that can bridge the gap. Soft electronics that utilize organic materials, such as conjugated polymers, can bring many important features to bioelectronics. Among the many advantages of conjugated polymers, the ability to modulate the biocompatibility, solubility, functionality, and mechanical properties through side chain engineering can alleviate the issues of mechanical mismatch and provide better interface between the electronics and biological elements. Additionally, conjugated polymers, being both ionically and electrically conductive through reversible doping processes provide means for direct sensing and stimulation of biological processes in cells, tissues, and organs. In this Account, we focus on our recent progress in molecular engineering of conjugated polymers with tunable biomimetic properties, such as biocompatibility, responsiveness, stretchability, self-healing, and adhesion. Our approach is general and versatile, which is based on functionalization of conjugated polymers with long side chains, commonly polymeric or biomolecules. Applications for such materials are wide-ranging, where we have demonstrated conductive, stimuli-responsive antifouling, and cell adhesive biointerfaces that can respond to external stimuli such as temperature, salt concentration, and redox reactions, the processes that in turn modify and reversibly switch the surface properties. Furthermore, utilizing the advantageous chemical, physical, mechanical and functional properties of the grafts, we progressed into grafting of the long side chains onto conjugated polymers in solution, with the vision of synthesizing solution-processable conjugated graft copolymers with biomimetic functionalities. Examples of the developed materials to date include rubbery and adhesive photoluminescent plastics, biomolecule-functionalized electrospun biosensors, thermally and dually responsive photoluminescent conjugated polymers, and tunable self-healing, adhesive, and stretchable strain sensors, advanced functional biocidal polymers, and filtration membranes. As outlined in these examples, the applications of these biomimetic, conjugated polymers are still in the development stage toward truly printable, organic bioelectronic devices. However, in this Account, we advocate that molecular engineering of conjugated polymers is an attractive approach to a versatile class of organic electronics with both ionic and electrical conductivity as well as mechanical properties required fo...

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Section: Grafting From Conjugated Polymers Deposited On Surfaces For ...mentioning

confidence: 97%

Section: Grafting Of Conjugated Polymers In Solution For Physicochemi...mentioning

confidence: 99%

Section: Grafting From Conjugated Polymers Deposited On Surfaces For ...mentioning

confidence: 99%