Conducting polymer hydrogels with electrically-tuneable mechanical properties as dynamic cell culture substrates

Ting, Matthew S.; Vella, Joseph; Raos, Brad; Narasimhan, Badri Narayanan; Svirskis, Darren; Travaš-Sejdić, Jadranka; Malmström, Jenny

doi:10.1016/j.msec.2021.112559

Cited by 5 publications

(4 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…; which may cause concern in biomedical application. A few recent investigations were reported on PNIPAM-based copolymeric hydrogel systems, e.g., Laponite ® platelets/PNIPAM hydrogel [ 162 ], polypyrrole/PNIPAM hydrogel [ 163 ], polyethylene glycol diacrylate (PEGDA)/chitosan (CS)/PNIPAM hydrogel [ 164 ], chitosan– N -2-hydroxypropyl trimethylammonium chloride (HACC)/PNIPAM hydrogel [ 165 ] etc. ; where biological properties and mechanical properties were improved.…”

Section: Formulation Approaches For Tailoring the Mechanical Behavior...mentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Ansari

Rajendran

Mohanto

et al. 2022

Gels

View full text Add to dashboard Cite

A prominent research topic in contemporary advanced functional materials science is the production of smart materials based on polymers that may independently adjust their physical and/or chemical characteristics when subjected to external stimuli. Smart hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) demonstrate distinct thermoresponsive features close to a lower critical solution temperature (LCST) that enhance their capability in various biomedical applications such as drug delivery, tissue engineering, and wound dressings. Nevertheless, they have intrinsic shortcomings such as poor mechanical properties, limited loading capacity of actives, and poor biodegradability. Formulation of PNIPAM with diverse functional constituents to develop hydrogel composites is an efficient scheme to overcome these defects, which can significantly help for practicable application. This review reports on the latest developments in functional PNIPAM-based smart hydrogels for various biomedical applications. The first section describes the properties of PNIPAM-based hydrogels, followed by potential applications in diverse fields. Ultimately, this review summarizes the challenges and opportunities in this emerging area of research and development concerning this fascinating polymer-based system deep-rooted in chemistry and material science.

show abstract

Section: Formulation Approaches For Tailoring the Mechanical Behavior...mentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Ansari

Rajendran

Mohanto

et al. 2022

Gels

View full text Add to dashboard Cite

show abstract

“…13,14 Engineering composites of conducting polymers and hydrogels has been extensively studied, as hydrogels are biocompatible, as soft as tissues and allow flexible fabrication. 15–17 These composites result in an interpenetrating network of conducting polymers within the hydrogel bulk and therefore have improved mechanical properties but at the cost of reduced electronic conductivity. 18–21 Recently, a pure PEDOT:PSS hydrogel was reported, based on an interconnected network of pure polymer fibrils, without the need of any additional cross-linking, resulting in a material with a low Young's modulus and good electrical and electrochemical properties.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 Engineering composites of conducting polymers and hydrogels has been extensively studied, as hydrogels are biocompatible, as soft as tissues and allow flexible fabrication. [15][16][17] These composites result in an a Laboratory of Organic Electronics, Department of Science and Technology, Linko ¨ping University, Norrko ¨ping 601 74, Sweden. E-mail: eleni.stavrinidou@liu.se b POLYMAT, University of the Basque Country UPV/EHU, Avenida Tolosa 72,…”

Section: Introductionmentioning

confidence: 99%

Electrochemical modulation of mechanical properties of glycolated polythiophenes

Abdel Aziz,

Gladisch,

Musumeci

et al. 2024

Mater. Horiz.

View full text Add to dashboard Cite

show abstract

“…Due to their unique properties, hydrogels have attracted considerable attention in the field of bioelectronics to provide seamless interfacing between biological tissues and electronics. , Based on this idea, hydrogels have been incorporated with CPs to form a hybrid material known as conducting polymer hydrogels (CPHs) in which a CP is grown within a hydrogel matrix. The hydrogel component provides a highly hydrophilic and porous network, and the CP component imparts electrical conductivity. − CPH coatings have found applications in drug delivery, , bioelectronics, and biosensors . CPH coatings have been recently explored for various bioelectronics applications offering mechanical properties similar to biological tissues and electrical properties comparable to conducting polymers. ,− Recently, researchers have reported the fabrication of CPH using an aqueous suspension of PEDOT:PSS dispersed within a hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Patternable Gelatin Methacrylate/PEDOT/Polystyrene Sulfonate Microelectrode Coatings for Neuronal Recording

Bansal

Vyas

Aqrawe

et al. 2022

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

This manuscript addresses the need for new soft biomaterials that can be fabricated on the surface of microelectrodes to reduce the mechanical mismatch between biological tissues and electrodes and improve the performance at the neural interface. By electrochemical polymerization of poly(3,4-dioxythiophene) (PEDOT)/polystyrene sulfonate (PSS) through a gelatin methacrylate (GelMA) hydrogel, we demonstrate the synthesis of a conducting polymer hydrogel (CPH) to meet the performance criteria of bioelectrodes. The hybrid material can be photolithographically patterned and covalently attached to gold microelectrodes, forming an interpenetrating network, as confirmed by infrared spectroscopy. The GelMA/PEDOT/PSS coatings were found to be reversibly electroactive by cyclic voltammetry and had low impedance compared to bare gold and GelMA-coated microelectrodes. The CPH coatings showed impedance at levels similar to conventional PEDOT/PSS coatings at a frequency of 1000 Hz. CPH exhibited electrochemical stability over 1000 CV cycles, and its performance was maintained over 14 days. Biocompatibility of the CPH coatings was confirmed by primary hippocampal neuronal cultures via a neuronal viability assay. The CPH-coated microelectrode arrays (MEAs) successfully recorded neuronal activity from primary hippocampal neuronal cells. The CPH GelMA/PEDOT/PSS is a highly promising coating material to enhance microelectrode performance at the neural interface.

show abstract

Conducting polymer hydrogels with electrically-tuneable mechanical properties as dynamic cell culture substrates

Cited by 5 publications

References 80 publications

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Electrochemical modulation of mechanical properties of glycolated polythiophenes

Patternable Gelatin Methacrylate/PEDOT/Polystyrene Sulfonate Microelectrode Coatings for Neuronal Recording

Contact Info

Product

Resources

About