Polymer‐Grafted Conjugated Polymers as Functional Biointerfaces

Hackett, Alissa J.; Strover, Lisa T.; Baek, Paul; Malmström, Jenny; Travaš-Sejdić, Jadranka

doi:10.1002/9783527342747.ch13

Cited by 8 publications

(10 citation statements)

References 212 publications

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“…Synthesis of P3HT-b-P3TEGT, schematic view of the approach for the preparation process of P3HTb-P3TEGT nanomicelles, schematic representation of self-assembly and nanomicelle formation, 1 H-NMR spectrum, 13…”

Section: * Sı Supporting Informationmentioning

confidence: 99%

“…9 , 10 The potential applications of CP materials in biosensors and biological applications have been reviewed extensively in the literature. 11,12,13 Biosensing applications of CP require bioconjugation of receptor such as proteins, peptides, lipids, or carbohydrates in the polymeric system to afford specific targeting. Such bioconjugation techniques usually require the introduction of chemical functions, typically amine or carboxylic acid, and chemical control over the ligand functionalization of the CP via pre-or post-functionalization.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the sensors reported are in line with the main requirements for selectivity, sensitivity, and fast analysis, with a detection limit down to the level of few hundreds of colony-forming units (cfu) per milliliters. Processable conjugated polymers (CPs) have been widely used as sensing materials in electrochemical sensors, thanks to their unique electrical and electrochemical responses in the presence of different analytes. , The potential applications of CP materials in biosensors and biological applications have been investigated extensively in the literature. − Biosensing applications of CP require bioconjugation of the receptor such as proteins, peptides, lipids, or carbohydrates in the polymeric system to afford specific targeting. Such a bioconjugation technique usually requires the introduction of chemical functions, (typically amine or carboxylic acid), and a chemical control over the ligand functionalization of the CP via pre- or postfunctionalization.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dispersible Conjugated Polymer Nanoparticles as Biointerface Materials for Label-Free Bacteria Detection

Elgiddawy

Ren

Yassar

et al. 2020

ACS Appl. Mater. Interfaces

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Fast and efficient identification of bacterial pathogens in water and biological fluids is an important issue in medicine, food safety and public health concerns that requires low-cost and improved sensing strategies. Impedimetric sensors are promising tools for monitoring bacteria detection, due to their reliability and ease-of-use. We herein report a study on a new bio-interface-based amphiphilic poly(3-hexylthiophene)-bpoly(3-triethylene-glycol-thiophene), P3HT-b-P3TEGT, for label-free impedimetric detection of Escherichia coli (E. coli). This bio-interface is fabricated by selfassembly of P3HT-b-P3TEGT into core-shell nanoparticles, which are further decorated with mannose, leading to an easy-to-use solution-processable nanoparticle material for biosensing. The hydrophilic block, P3TEGT promotes antifouling and prevents non-specific interactions while improving the ionic and electronic transport properties, thus enhancing the electrochemical-sensing capability in aqueous solution. Self-assembly and micelle formation of P3HT-b-P3TEGT were analyzed by 2D-NMR, FTIR, DLS, contact angle and microscopy characterizations. Detection of E. coli was characterized and evaluated by electrochemical impedance spectroscopy, optical and scanning electron microscopy techniques. The sensing layer based on mannose-functionalized P3HT-b-P3TEGT nanoparticles demonstrates targetingability toward E. coli pili protein with a detection range from 10 3 CFU/mL to 10 7 CFU/mL and selectivity studied with Gram(+)bacteria. Application to real samples was performed by detection of bacteria in tap water and Nile water. The approach developed here shows that water/alcohol-processable functionalized conjugated polymer nanoparticles are suitable for use as electrode materials for the fabrication of a low-cost label-free impedimetric biosensor for the detection of bacteria in water.

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Section: * Sı Supporting Informationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dispersible Conjugated Polymer Nanoparticles as Biointerface Materials for Label-Free Bacteria Detection

Elgiddawy

Ren

Yassar

et al. 2020

ACS Appl. Mater. Interfaces

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“…It ensures a highest degree of property mixing among associated species and thus, offers the scope of material design as per the requirement. General methods to synthesize graft copolymers are of three types: (i) 'grafting to', (ii) 'grafting from' and (iii) 'grafting through' (Figure 1) [35]. In brief, 'grafting to' method involves attachment of pre-polymerized chains to backbone polymer having reactive end-groups [36].…”

Section: Covalent Grafting Of Conducting Polymersmentioning

confidence: 99%

“…In a similar way, Abd El- Generalized categories of graft copolymer synthesis: grafting through (macromonomer approach), grafting from (macroinitiator approach), and grafting to. Reproduced with permission [35].…”

Section: Covalent Grafting Of Conducting Polymersmentioning

confidence: 99%

Conducting Polymer Grafting: Recent and Key Developments

Maity

Dawn

2020

Polymers

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Since the discovery of conductive polyacetylene, conductive electroactive polymers are at the focal point of technology generation and biocommunication materials. The reasons why this research never stops growing, are twofold: first, the demands from the advanced technology towards more sophistication, precision, durability, processability and cost-effectiveness; and second, the shaping of conducting polymer research in accordance with the above demand. One of the major challenges in conducting polymer research is addressing the processability issue without sacrificing the electroactive properties. Therefore, new synthetic designs and use of post-modification techniques become crucial than ever. This quest is not only advancing the field but also giving birth of new hybrid materials integrating merits of multiple functional motifs. The present review article is an attempt to discuss the recent progress in conducting polymer grafting, which is not entirely new, but relatively lesser developed area for this class of polymers to fine-tune their physicochemical properties. Apart from conventional covalent grafting techniques, non-covalent approach, which is relatively new but has worth creation potential, will also be discussed. The aim is to bring together novel molecular designs and strategies to stimulate the existing conducting polymer synthesis methodologies in order to enrich its fascinating chemistry dedicated toward real-life applications.

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