Modulation by Casein and Soybean Protein Amino Acid Mixtures of Insulin- and Glucagon-dependent Linoleic Acid Desaturation in Primary-cultured Rat Hepatocytes

Koba, Kazunori; Imaizumi, Kazunori; Obata, Keisuke; Hirata, Keizaburo; Sugano, Michihiro

doi:10.1271/bbb.58.1073

Cited by 4 publications

(1 citation statement)

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“…It markedly decreases the activity of hepatic lipogenic enzymes (Iritani and others 1986). Soy protein in relation to casein tends to reduce the metabolism of linoleic and arachidonic acid and hence the production of several eicosanoids (Koba and others 1994). Soy protein isolate, in comparison with casein, induces a low postprandial insulin/glucagon ratio (Sanchez and Hubbard 1991) and promoted a decrease of lipid peroxide, cholesterol, and triglyceride content of atherogenic lipoproteins, which had beneficial effects over atherosclerosis progression in cholesterol‐fed rabbits (Damasceno and others 2001).…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic Effect of Sesame (Sesamum indicum L.) Protein Isolate in Rats Fed a Normal and High Cholesterol Diet

Biswas

Dhar

Ghosh

2010

Journal of Food Science

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The dietary influence of sesame protein isolate (protein content 91.5%), produced from dehulled, defatted sesame meal, on blood and tissue lipid profile and lipid peroxidation has been assessed in normal and hypercholesterolemic rats. To evaluate their hypocholesterolemic and antioxidative activity in vivo, we fed 18% sesame protein isolate with or without 2% cholesterol in comparison with casein to rats for 28 d. We determined plasma total protein, total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triacylglycerol as well as susceptibility of plasma and erythrocyte membrane lipid to oxidation ex vivo. Liver tissue lipid, cholesterol, phospholipids, and lipid peroxidations were also determined. The total cholesterol, LDL-cholesterol and triacylglycerol levels were significantly reduced in the sesame protein isolate and isolate containing cholesterol group than the corresponding control casein groups. HDL-cholesterol level was also increased in sesame protein isolate (41%) and protein isolate containing cholesterol group (38%) than the corresponding control casein and casein containing cholesterol groups. There was 49% and 64% lowering of plasma lipid peroxidation as well as 36% and 56% lowering of lipoprotein oxidation susceptibility (LOS) in the 2 experimental groups (sesame protein isolate and isolate containing cholesterol group) than the corresponding control (casein and casein containing cholesterol) groups. There was significant lowering of erythrocyte membrane lipid peroxidation (68% and 63% lowering in sesame protein isolate and isolate containing cholesterol groups) and liver lipid peroxidation (61% and 76% lowering in the 2 experimental groups than the corresponding control casein groups). Therefore, our results indicate that sesame protein isolate decreases cholesterol concentration in plasma, increases HDL-cholesterol, and also decreases plasma and erythrocyte membrane lipid peroxidation with or without cholesterol fed diet in rats.

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