Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK)

Aoyama, Toyohiko; Fukui, Kensuke; Takamatsu, Kiyoharu; Hashimoto, Yukio; Yamamoto, Takashi

doi:10.1016/s0899-9007(00)00230-6

Cited by 183 publications

(126 citation statements)

References 17 publications

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“…Current evidence from in vitro and animal studies suggest that soy protein and isoflavones may promote weight loss and prevent body fat gain, with additional benefits over other protein sources. [7][8][9] Epidemiologic observations also indicated that persons with high soy food consumption have lower BWs than those with low soy intakes. 10,11 A crosssectional study in western postmenopausal women 10 suggested a significant inverse relation between isoflavone consumption and BW, body mass index (BMI), waist circumference (WC), and total body FM (assessed by bioelectric impedance analysis).…”

Section: Introductionmentioning

confidence: 99%

A mild favorable effect of soy protein with isoflavones on body composition—a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women

et al. 2009

Int J Obes

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Background: In vitro and animal studies suggested that soy protein and isoflavones promote weight and body fat loss. However, clinical trials in humans were few and the effects remained uncertain. Objectives: To examine whether soy protein with isoflavones and isoflavone extracts exert beneficial effects on body composition among postmenopausal women. Design: A double-blind randomized placebo-controlled trial was conducted among 180 postmenopausal Chinese women with mild hyperglycemia. After a 2-week adaptation, participants were randomly assigned to one of the three arms to receive 15 g soy protein and 100 mg isoflavones (Soy group), or 15 g milk protein and 100 mg isoflavones (Iso group), or 15 g milk protein (placebo group) on a daily basis for 6 months. Results: We observed a mild but significant favorable effect of soy protein with isoflavones on the changes of body weight (BW), body mass index, and body fat percentage relative to isoflavone extracts and milk protein after 6-month supplementation. The mean differences of BW between the Soy and the Iso groups were À0.75 kg (95% CI: À1.363 to À0.136, P ¼ 0.017), and between the Soy and the placebo groups were À0.60 kg (95% CI: À1.209 to À0.019, P ¼ 0.047). The mean difference of change percentage in body fat percentage between the Soy and the Iso groups was À3.74% (95% CI: À6.88 to À0.60%, P ¼ 0.02), and between the Soy and the placebo groups was À2.54% (95% CI: À5.69 to 0.12%. P ¼ 0.08). Conclusions: Six-month supplementation of soy protein with isoflavones had a mild favorable effect on body composition in postmenopausal women.

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Section: Introductionmentioning

confidence: 99%

A mild favorable effect of soy protein with isoflavones on body composition—a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women

et al. 2009

Int J Obes

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“…It is also reported that the isolated protein maintains in a low levelplasma triglycerides, increases adiponectin, accelerates lipid metabolism and decreases the body fat of obese rats and mice 61,62 .…”

Section: Bioactive Peptidesmentioning

confidence: 96%

Cholesterol Metabolism and Its Regulation by Functional Foods

Yasser¹,

Betancur‐Ancona²,

Cristian³

et al. 2016

IJEAB

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“…Aoyama et al 5,6 fed fattened Sprague-Dawley rats energy-restricted, low-fat 5 , and high-protein 35 casein, soy protein isolate SPI , or soy protein isolate hydrolysate SPI-H diets for 4 weeks at 60 of the level of the energy intake of rodents on laboratory chow, and found that the apparent absorbability of dietary energy and fat was signifi cantly lower in the SPI and SPI-H groups than in the casein group. They concluded that SPI and SPI-H were suitable protein sources in energy-restricted diets for the treatment of obesity.…”

Section: Dicussionmentioning

confidence: 99%

The Mechanism of Weight-Loss Promoting Effects of Oil Heated with Vegetable Protein

et al. 2010

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We have previously reported that a soy oil-containing experimental diet (fat-free AIN93G containing oil thermally processed with soybean protein followed by filtration), inhibited body weight increases without any adverse effects when given ad libitum to male Wistar rats for 12 weeks. In the present paper, the mechanism of weight-loss promoting effects was investigated. Fasted 10-week-old rats were fed a slurry composed of AIN93G (fat-free), Cr 2 O 3 (marker), water, and 7 wt% soy oil or fresh oil (control) and sacrifi ced at 20, 60, 90, 120, 150, 210, 270 or 360 min. The stomach, small intestine, cecum, colon and feces were then collected to determine the distribution of the slurry in the digestive tract. The results indicated that the content was transferred faster from stomach to small intestine in the soy oil group than in the control group. Fecal excretion (derived from a commercial standard diet ingested before slurry administration) in the soy oil group was signifi cantly higher than in the control group. Digestive enzyme activities, lipase, sucrose, and maltose, were not inhibited by soy oil. In addition, feces collected in the 12-week feeding experiment were more in the dry weight and contained higher levels of nitrogen and water in the soy oil group than in the control group, revealing that an increased amount of nutrition was continuously excreted in the former group. The above-described findings suggest that soy oil stimulated peristalsis of the gastrointestinal tract and that colon contents are actively excreted, resulting in safe and steady body weight decreases.

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Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK)

Cited by 183 publications

References 17 publications

A mild favorable effect of soy protein with isoflavones on body composition—a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women

A mild favorable effect of soy protein with isoflavones on body composition—a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women

Cholesterol Metabolism and Its Regulation by Functional Foods

The Mechanism of Weight-Loss Promoting Effects of Oil Heated with Vegetable Protein

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