Modulating Efficiency of γ-Irradiated Rosemary in Improving the Hepatic Antioxidant Status of Ethanol Administrated Rats

Abstract

Especially during picking, processing and packing, rosemary is susceptible to contamination by pathogenic microorganisms [12]. Gamma radiation is a highly effective means of inhibiting the growth of undesirable microbes and avoiding the occurrence of food-transmitted diseases. This is substantiated by the fact that an increasing number of countries have adopted irradiation as a way to ensure the hygienic quality of dehydrated foods [13]. The international safe dose clearance is up to 10 kGy, though some countries, including Argentina, have increased this level to 30 kGy without any harmful effects being observed [14]. Also, the effect of irradiation on some of the compounds responsible for antioxidant activity in rosemary has been reported by Koseki et al. [15], Calucci et al. [16] and El-Beltagi et al. [17]. The objective of the study is therefore to evaluate the efficiency of dietary supplementation with raw and γ-irradiated rosemary in improving the hepatic antioxidant status of ethanol administrated rats. Material and Methods Materials Rosemary (Rosmarinus officinalis L.) powder and standard commercial rodent diet were purchased from local herbal market (Cairo, Egypt), while ethanol was purchased from Sigma Company. Gamma irradiation process The samples of dry rosemary powder were transferred into polyethylene bags and treated with 10 kGy of gamma rays, using a 60Co source at a dose rate of 4.70 kGy/h at the National Centre for Radiation Research and Technology (NCRRT), Egypt.

Protective Effect of Nutmeg and Rosemary on Oxidative Stress in Hypercholesterolemic Rats

“…Under normal conditions, there is a natural defense system provided by several enzymes such as Superoxide Dismutase (SOD), Catalase (CAT) , Glutathione Peroxidase (GSH-Px) and nonenzymatic antioxidants Glutathione reduced (GSH) which performs a vital role for detoxification of free radicals. The use of antioxidant rich food or antioxidant food supplements became immensely popular since many diseases have been associated with oxidative stress [61].Therefore the objective of this research was to investigate the effect of nutmegs, rosemary essential oils on antioxidant enzyme in rats hypercholesterolemic diet after 8weeks of treatment. Nutmegs and rosemary contains characteristic polyphenolic compounds .The most important function of these compounds can either stimulate endogenous antioxidant defense systems or scavenge reactive species [44].…”

Hazardous Effects of HighVoltage on Albino Rats and Role of Rosmarinus Officinalis

“…Rosemary has increased renal CAT reduction and decreased MDA scale elevation, which can be due to the antioxidant properties that inhibit LPO(Hassanen 2015). The Usage of food, which contains high antioxidants, became immensely popular since plentiful diseases have been associated with oxidative stress(Hamzaa et al 2012). The most crucial function of antioxidants is to stimulate endogenous antioxidant defense systems or scavenge interactive species…”