Modulated release of triterpenic compounds from a O/W/O multiple emulsion formulated with dimethicones: infrared spectrophotometric and differential calorimetric approaches

A comparison of topical formulations for the prevention of human schistosomiasis

“…However, the fact that the anti-penetration ability of the water-in-oil dimeticone formulation persists under similar conditions indicates that it is not simply acting as a barrier and that its site of action probably lies within the stratum corneum. It has previously been reported that silicones interact with the lipids of the skin and that this interaction is most apparent with lower-molecular-weight dimeticones (Laugel et al 2000). Thus, it is possible that the fact that the silicone formulation is a water-in-oil emulsion containing dimeticone 350 may facilitate its interaction with the stratum corneum.…”

Mass Transfers Within Emulsions Studied by Differential Scanning Calorimetry (DSC) - Application to Composition Ripening and Solid Ripening

“…The extracted molecule is then directly released in the external phase which ruins the extraction process (Yan & Pal, 2001, 2004Mortaheb et al, 2008). If O/W/O multiple emulsions have been less extensively studied, they can also finds potential applications in food, cosmetics and controlled delivery drugs Mishra & Pandit, 1989;Laugel et al, 1998Laugel et al, , 2000Yu et al, 2003). They are found also in application in separation processes of hydrocarbons (Krishna et al, 1987;Garti & Kovacs, 1991).…”

Natural polymer-stabilized multiple water-in-oil-in-water emulsions: a novel dermal drug delivery system for 5-fluorouracil

“…[1,2,[4][5][6][7][8] With the use of multiple W/O/W emulsions, we can expect two principal advantages: (1) hydrophilic drugs incorporated in aqueous droplets will be protected by a hydrophobic layer; and (2) due to this protection, these formulations should influence the skin distribution of actives after topical application. [2,9] To maintain these advantages, the preservation of the microstructure is of great importance.…”