Natural polymer-stabilized multiple water-in-oil-in-water emulsions: a novel dermal drug delivery system for 5-fluorouracil

Hoppel, Magdalena; Mahrhauser, Denise-Silvia; Stallinger, Christina; Wagner, Florian; Wirth, Michael; Valenta, Claudia

doi:10.1111/jphp.12194

Cited by 18 publications

(6 citation statements)

References 37 publications

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“…In this technique, elevated temperatures or agents for inducing phase separation are not needed, and sterile microcapsules can also be produced by scaling up microencapsulation (ME) [124,125]. Based on the drug state in the polymer solution and the dispersion medium, the emulsion method is categorized into oil-in-water (o/w), waterin-oil (w/o), and water-in-oil-in-water (w/o/w) double emulsion methods [126,127]. Among the methods used for MS preparation, the w/o/w solvent evaporation is the most commonly practiced technique [128].…”

Section: Water-in-oil-in-water (W/o/w) Double Emulsion Methodsmentioning

confidence: 99%

An overview of the development of composites containing Mg and Zn for drug delivery

Niazvand¹,

Cheshmi

Zand

et al. 2020

jcc

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Section: Water-in-oil-in-water (W/o/w) Double Emulsion Methodsmentioning

confidence: 99%

An overview of the development of composites containing Mg and Zn for drug delivery

Niazvand¹,

Cheshmi

Zand

et al. 2020

jcc

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“…Natural polymers are biogenic, and their biological properties such as cell recognition and interactions, enzymatic degradation, extracellular matrix-like appearance, and chemical stability make them materials of choice for drug delivery [6]. The natural polymers have the varieties of role in the drug delivery system such as emulsification [7], suspension [8], retarding the drug release [9], film coating [10], disintegration [11], solubilization, bioadhesion, gelling, thickening, viscosity modulation, bulking agent [12], drug encapsulation, and mechanical enhancer [13][14][15]. The use of natural polymers in the targeted drug delivery system is also increasing day by day.…”

Section: Introductionmentioning

confidence: 99%

Extraction, Modification, and Characterization of Natural Polymers Used in Transdermal Drug Delivery System: An Updated Review

Biswas¹,

Das²,

Mohanto³

et al. 2020

Asian J Pharm Clin Res

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The modified/regulated drug delivery system helps to sustain the delivery of the drug for a prolonged period. The modified drug delivery system is primarily aimed at ensuring protection, the effectiveness of the drug, and patient compliance. The transdermal drug delivery system (TDDS) falls within the modified drug delivery system, in which the goal is to deliver the drug at a fixed dose and regulated rate through the skin. Polymers are the backbone of the framework for providing transdermal systems. The polymer should be stable, non-toxic, economical, and provide a sustainable release of the drug. In general, natural polymers used in the TDDS as rate-controlling agents, protective, and stabilizing agents and also used to minimize the frequency of dosing and improve the drug’s effectiveness by localizing at the site of action. Nowadays, manufacturers are likely to use natural polymers due to many issues associated with drug release and side effects with synthetic polymers. Drug release processes from natural polymers include oxidation, diffusion, and swelling. Natural polymers may be used as the basis to achieve predetermined drug distribution throughout the body. The use of natural materials for traditional and modern types of dosage forms are gums, mucilages, resins, and plant waste etc. Thus, the main objective of this review article is to give a brief knowledge about the extraction, modification, characterization, and biomedical application of conventional natural polymers used in the transdermal drug delivery system and their future prospective.

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“…7 Recently, the multiple water-in-oil-in-water (W/O/W) emulsions are of great interest, due to the opportunity to delivery hydrophilic active ingredients through the skin. [8][9][10] Hoppel et al reported that W/O/W emulsions could significantly increase penetration of acetyl hexapeptide-8 into porcine skin compared to simple water-in-oil and oil-in-water emulsions. 8 However, W/O/W emulsions are thermodynamically unstable with a strong tendency towards coalescence, flocculation, and creaming.…”

Section: Introductionmentioning

confidence: 99%

Transdermal solid delivery of epigallocatechin-3-gallate using self-double-emulsifying drug delivery system as vehicle: Formulation, evaluation and vesicle-skin interaction

Fang

et al. 2015

J Biomater Appl

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The present study investigated a self-double-emulsifying drug delivery system loaded with epigallocatechin-3-gallate to improve epigallocatechin-3-gallate skin retention. The long chain solid lipids (cetostearyl alcohol) and macadamia oil were utilized as a carrier to deliver the bioactive ingredient. Response surface methodology was used to optimize the formulation, and the solid lipid to total lipid weight ratio, concentration of epigallocatechin-3-gallate and hydrophilic surfactant on skin retention were found to be the principal factors. The optimum formulation with high encapsulation efficiency (95.75%), self-double-emulsification performance (99.58%) and skin retention (87.24%) were derived from the fitted models and experimentally examined, demonstrating a reasonable agreement between experimental and predicted values. Epigallocatechin-3-gallate-self-double-emulsifying drug delivery system was found to be stable for 3 months. Transdermal studies could explain a higher skin diffusion of epigallocatechin-3-gallate from the self-double-emulsifying drug delivery system compared with EGCG aqueous solution. In vitro cytotoxicity showed that epigallocatechin-3-gallate-self-double-emulsifying drug delivery system did not exert hazardous effect on L929 cells up to 1:10.

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Natural polymer-stabilized multiple water-in-oil-in-water emulsions: a novel dermal drug delivery system for 5-fluorouracil

Abstract: Solagum AX is highly suitable for stabilization of the created multiple emulsions. Moreover, these formulations showed superiority over a simple O/W-macroemulsion regarding skin permeation and penetration of 5-fluorouracil.

Cited by 18 publications

References 37 publications

An overview of the development of composites containing Mg and Zn for drug delivery

An overview of the development of composites containing Mg and Zn for drug delivery

Extraction, Modification, and Characterization of Natural Polymers Used in Transdermal Drug Delivery System: An Updated Review

Transdermal solid delivery of epigallocatechin-3-gallate using self-double-emulsifying drug delivery system as vehicle: Formulation, evaluation and vesicle-skin interaction

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