Modifying Fe₃O₄-Functionalized Nanoparticles with N-Halamine and Their Magnetic/Antibacterial Properties

Abstract

Magnetic/antibacterial bifunctional nanoparticles were fabricated through the immobilization of antibacterial N-halamine on silica-coated Fe(3)O(4)-decorated poly(styrene-co-acrylate acid) (PSA) nanoparticles. The samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectra (XPS), X-ray diffraction (XRD), energy-dispersive X-ray spectrometry (EDX), Fourier transform infrared (FTIR), and thermogravimetric analysis (TGA). The N-halamine was developed from the precursor 5,5-dimethylhydantoin (DMH) by chlorination treatment, and experimental results showed that the loading amount of DMH on the silica-coated Fe(3)O(4)-decorated poly(styrene-co-acrylate acid) nanoparticles was adjustable. The as-synthesized nanoparticles exhibited superparamagnetic behavior and had a saturation magnetization of 18.93 emu g(-1). Antibacterial tests showed that the resultant nanoparticles displayed enhanced antibacterial activity against both Gram-positive and Gram-negative bacteria compared with their bulk counterparts.

High-flux, antibacterial ultrafiltration membranes by facile blending with N-halamine grafted halloysite nanotubes

“…18 An alternative approach is to use N-halamine nanocomposites as antibacterial additives. 17 Several kinds of N-halamine additives loaded on different mineral llers, magnetic silica nanoparticles 15,19 and calcium carbonate, 17 have been developed. Halloysite (Al 2 Si 2 O 5 (OH) 4 $2H 2 O) is one of the most widely used mineral llers to modify various polymer materials such as polyetherimide, polyamide, epoxy resin and rubbers due to its high surface area, large aspect ratio and hollow structure.…”

Bactericidal evaluation of N-halamine-functionalized silica nanoparticles based on barbituric acid

“…Therefore, an area of ongoing research has focused on effective fabrication of antibacterial materials with nanostructure as novel antimicrobial agents to improve their antibacterial performances [25]. In our previous study, we carried out the synthesis of hydantoin-originated N-halamine nanoparticles with 3-(methacryloxy)propyl trimethoxysilane grafted silica nanoparticles, polystyrene-functionalized silica nanoparticles, magnetic silica nanoparticles, and magnetic poly(styrene-co-acrylic acid) nanoparticles as support materials, respectively [26][27][28][29]. Introduction of these nanostructures as template successfully enhanced the activated surface, and all these as-prepared N-halaminefunctionalized nanoparticles possessed enhanced antibacterial activity against both Gram-positive and Gram-negative bacteria compared with their bulk powder counterparts.…”

A Facile Sonochemical Route for the Fabrication of Magnetic Protein Microcapsules for Targeted Delivery

“…[32] Briefly, a mixture of FeCl 3 ·6 H 2 O (2.017 g) and FeCl 2 ·4 H 2 O (0.742 g) was dissolved in water (100 mL degassed by bubbling N 2 prior to use) and heated to 80 8C under N 2 protection. [32] Briefly, a mixture of FeCl 3 ·6 H 2 O (2.017 g) and FeCl 2 ·4 H 2 O (0.742 g) was dissolved in water (100 mL degassed by bubbling N 2 prior to use) and heated to 80 8C under N 2 protection.…”