A Facile Sonochemical Route for the Fabrication of Magnetic Protein Microcapsules for Targeted Delivery

Cui, Xuejun; Li, Zhanfeng; Zhong, Shuangling; Wang, Bingnan; Han, Yongsheng; Wang, Hongyan; Möhwald, Helmuth

doi:10.1002/chem.201301302

Cited by 25 publications

(14 citation statements)

References 33 publications

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“…First of all, core-shell BSA@Fe 3 O 4 MNPs were prepared by BSA molecules binding with Fe 3 O 4 MNPs (Scheme 1A), which had been discussed in our previous papers [39,40]. For BSA@Fe 3 O 4 MNPs, there were plenty of cysteine residues with sulfhydryl groups in the BSA layers, which was one of critical factors to fabricate BSA MCs [41].…”

Section: Synthesis Schematic Of Fa-bsa@fe 3 O 4 Mcsmentioning

confidence: 99%

Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Synthesis Schematic Of Fa-bsa@fe 3 O 4 Mcsmentioning

confidence: 99%

Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…For some magnetic protein microcapsules, magnetic nanoparticles can be first modified with protein molecules to form composite nanoparticles with core–shell structure before the implementation of high‐intensity ultrasound at the diphase interface, and subsequently are doped in aqueous protein solution to fabricate magnetic shells via the in situ sonication. From TEM images of BSA‐Fe 3 O 4 microcapsules (Image a in Figure ), it is clearly seen that Fe 3 O 4 nanoparticles are embedded evenly in the microcapsules, forming a dense magnetic protein layer. To confirm their existence sites more veritably, the green fluorescein isothiocyanate (FITC) labeling BSA, namely FITC‐BSA, is used to modify Fe 3 O 4 nanoparticles instead of pure BSA, and takes part in the preparation of magnetic microcapsules.…”

Section: Targeting and Stimuli‐responsive Behaviors Of Pmsmentioning

confidence: 99%

“…a) TEM image of the MPMCs, b) a confocal fluorescence microscopy image of the MPMCs labeled the BSA‐Fe 3 O 4 MNPs in the shell with a green dye (BSA‐FITC). Reproduced with permission . Copyright 2013, Wiley‐VCH Verlag GmbH & Co. KGaA.…”

Section: Targeting and Stimuli‐responsive Behaviors Of Pmsmentioning

confidence: 99%

Sonochemistry‐Assembled Stimuli‐Responsive Polymer Microcapsules for Drug Delivery

Wang

et al. 2018

Adv Healthcare Materials

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Stimuli-responsive polymer microcapsules (PMs) fabricated by the sonochemical method have emerged for developing useful drug delivery systems, and the latest developments are mainly focusing on the synthetic strategies and properties such as structure, size, stability, loading capacity, drug delivery, and release. There, the primary attribution of sonochemistry is to offer a simple and practical approach for the preparation of PMs. Structure, size, stability, and properties of PMs are designed mainly according to synthetic materials, implementation schemes, or specific demands. Numerous functionalities of PMs based on different stimuli are demonstrated: targeting motion in a magnetic field or adhering to the living cells with sensitive sites through molecular recognition, and stimuli-triggered release including enzymatic catalysis, chemical reaction as well as physical or mechanical process. The current review discusses the basic principles and mechanisms of stimuli effects, and describes the progress in the application such as targeted drug systems and controlled drug systems, and also gives an outlook on the future challenges and opportunities for drug delivery and theranostics.

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“…By encapsulated inside these microcapsules, drugs or chemicals can be released at a desired rate only when and/or where the release is needed . A considerable amount of researches have been carried out on temperature‐responsive, pH‐responsive, magnetic‐responsive, and other stimuli‐responsive microcapsules in recent years. However, in many cases, different environmental changes may occur at the same time, thus single stimulus‐responsive microcapsules are insufficient for practical applications.…”

Section: Introductionmentioning

confidence: 99%

Multi‐Stimuli‐Responsive Microcapsules for Adjustable Controlled‐Release

Wei

Zou

et al. 2014

Adv Funct Materials

150

122

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Novel multi‐stimuli‐responsive microcapsules with adjustable controlled‐release characteristics are prepared by a microfluidic technique. The proposed microcapsules are composed of crosslinked chitosan acting as pH‐responsive capsule membrane, embedded magnetic nanoparticles to realize “site‐specific targeting”, and embedded temperature‐responsive sub‐microspheres serving as “micro‐valves”. By applying an external magnetic field, the prepared smart microcapsules can achieve targeting aggregation at specific sites. Due to acid‐induced swelling of the capsule membranes, the microcapsules exhibit higher release rate at specific acidic sites compared to that at normal sites with physiological pH. More importantly, through controlling the hydrodynamic size of sub‐microsphere “micro‐valves” by regulating the environment temperature, the release rate of drug molecules from the microcapsules can be flexibly adjusted. This kind of multi‐stimuli‐responsive microcapsules with site‐specific targeting and adjustable controlled‐release characteristics provides a new mode for designing “intelligent” controlled‐release systems and is expected to realize more rational drug administration.

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A Facile Sonochemical Route for the Fabrication of Magnetic Protein Microcapsules for Targeted Delivery

Cited by 25 publications

References 33 publications

Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release

Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release

Sonochemistry‐Assembled Stimuli‐Responsive Polymer Microcapsules for Drug Delivery

Multi‐Stimuli‐Responsive Microcapsules for Adjustable Controlled‐Release

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