Bactericidal evaluation of N-halamine-functionalized silica nanoparticles based on barbituric acid

Dong, Alideertu; Xue, Min; Lan, Shi; Wang, Qin; Zhao, Yue; Wang, Ying; Zhang, Yanling; Gao, Ge; Liu, Fengqi; Harnoode, Chokto

doi:10.1016/j.colsurfb.2013.09.048

Cited by 43 publications

(37 citation statements)

References 56 publications

(59 reference statements)

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“…The N-halamines with larger surface area can give more antibacterial functional sites to combat bacteria as a result showing enhanced biocidal efficiency. Thereby, nano-sized N-halamines could appear more overwhelming bactericidal activity over their bulk powder counterparts which has been proven repeatedly in our previous reports (Dong et al, , 2011a(Dong et al, -c, 2013(Dong et al, , 2014a. Stability is another decisive factor determining the antibacterial activity and even the subsequent applications of N-halamines (Barnes et al, 2006).…”

Section: Introductionmentioning

confidence: 89%

“…On contrary, the population reduction of the bacterial colonies is visible after contacting with the ANHP NPs which demonstrates the excellent antimicrobial activity of the ANHP NPs towards E. coli. We believe that such a powerful antibacterial activity of the ANHP NPs is competitive enough to those reported previously (Dong et al, , 2011a(Dong et al, -c, 2013(Dong et al, , 2014a. In order to investigate the role of DksA, we constructed the DksA deletion mutant strain via replacing DksA with cat by one step inactivation method (Datsenko and Wanner, 2000) from E. coli wildtype strain BW25113, named as MOR1050.…”

Section: Antibacterial Evaluation Of the Anhp Npsmentioning

confidence: 99%

“…Oxidative chlorine content of the ANHP NPs was determined by the modified iodometric/thiosulfate titration procedure (Dong et al, 2014a). The percentage of active chlorine (Cl %) for the sample was calculated according to the following equation (Dong et al, 2014a).…”

Section: Determination Of Oxidative Chlorine Contentmentioning

confidence: 99%

“…%) and stirred at room temperature. The as-prepared ANHP NPs were washed thoroughly with a mixture of water and ethanol and then dried at 40°C for 24 h to remove any remaining free chlorine from the surface of the sample (Dong et al, 2014a).…”

Section: Synthesis Of Anhp Npsmentioning

confidence: 99%

“…The percentage of active chlorine (Cl %) for the sample was calculated according to the following equation (Dong et al, 2014a).…”

Section: Determination Of Oxidative Chlorine Contentmentioning

confidence: 99%

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Effect of DksA Protein on the Susceptibility of Escherichia coli Towards Novel Amine N-Halamine Polymeric Nanoparticles as Powerful Antibiotics

Dong¹,

Fan²,

Dong³

2015

Biotechnology

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A B S T R A C TA novel amine N-halamine polymeric nanoparticles (ANHP NPs) based on 4-(allyloxy)-2,2,6,6-tetramethylpiperidine (ATMP) were well developed as an antimicrobial agents by the aid of the radical copolymerization for deactivating pathogenic bacteria. The as-prepared ANHP NPs were systematically characterized by the different physical and chemical techniques like 1 H NMR, FTIR, SEM and the modified iodometric/thiosulfate method. Sterilizing action of the ANHP NPs on bacterial strain was evaluated by selecting different types of Escherichia coli (E. coli) strains as model microorganisms. The effect of DksA protein on the susceptibility of E. coli towards the ANHP NPs was investigated via the plate counting technique and the zone of inhibition test. The experimental results showed that DksA protein has an excellent resistance against the ANHP NPs. Such an in-depth study on the DksA effect on the susceptibility of E. coli against the antibiotics opens up a new thought for us to develop the novel potential antibiotics.

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Section: Introductionmentioning

confidence: 89%

Section: Antibacterial Evaluation Of the Anhp Npsmentioning

confidence: 99%

Section: Determination Of Oxidative Chlorine Contentmentioning

confidence: 99%

Section: Synthesis Of Anhp Npsmentioning

confidence: 99%

“…The percentage of active chlorine (Cl %) for the sample was calculated according to the following equation (Dong et al, 2014a).…”

Section: Determination Of Oxidative Chlorine Contentmentioning

confidence: 99%

See 3 more Smart Citations

Effect of DksA Protein on the Susceptibility of Escherichia coli Towards Novel Amine N-Halamine Polymeric Nanoparticles as Powerful Antibiotics

Dong¹,

Fan²,

Dong³

2015

Biotechnology

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Construction of silicone with quaternized hydantoin‐based N‐chloramines on cotton with aid of supercritical interpenetration for antibacterial synergism

Chen,

Suo,

Pei

et al. 2024

J of Applied Polymer Sci

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A silicone carrying combined functionalities of different mechanisms and physiochemical properties is synthesized as a strategy for faster and broader bacterial eliminations. Briefly, ring‐opening alcoholysis of succinic anhydride with 2‐dimethylaminoethanol and subsequent esterification of the alcoholysis product with 5‐(4‐hydroxyphenyl)imidazolidine‐2,4‐dione produced a structure with one tertiary amine and two hydantoinyl NH bonds. The tertiary amine was quaternized with 3‐chloro‐1‐propanol whose OH was then alcoholyzed with SiH of poly(methylhydrosiloxane). The polymeric product was interpenetrated into cotton at 30 MPa and 50°C in supercritical CO2 and treated with tert‐butyl hypochlorite to chlorinate its hydantoinyl NH bonds, forming a 78 nm biocidal layer of silicone with quaternized hydantoin‐based N‐chloramines. Antibacterial tests showed that the quaternary ammonium salt and two hydantoin‐based N‐chloramines act synergistically due to their complementary features, killing both Staphylococcus aureus and Escherichia coli much more efficiently than each functionality. More importantly, the ratio of N‐chloramine to quaternary ammonium salt of 2:1 herein also provided higher efficacy than a reported counterpart with a 1:1 ratio. Biocidability of the modified cotton had promising stability and rechargeability, which indicates that supercritical interpenetration produced a durable interfacial layer without the necessity of chemical bonding.

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Antimicrobial Properties of Azole Functional Silica Nanocomposites

Usul,

Lüleci,

Ergüden

et al. 2023

ChemistrySelect

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Silica nanoparticles have become more attractive due to their surface characteristics, versatility, biocompatibility, and morphological and physicochemical properties. For this reason, their use in biological applications has been expanding in recent years. In this study, after functionalizing silica nanoparticles with glycidyl methacrylate monomer, nanocomposites were formed by attaching 1,2,4‐Triazole, 3‐Amino‐1,2,4‐Triazole, and 5‐Aminotetrazole particles to the surface. Notably, the thermal degradation temperature of all nanocomposites was determined to surpass 200 °C. However, it is worth mentioning that despite the favorable water uptake rates observed for MT(7.64 %) and M3(5.98 %) nanocomposites, MT did not exhibit resistance against Fenton chemicals and experienced degradation. It is important to note that the material loss in M3 nanocomposites is minimal, measuring less than 1 %. In order to reveal the antifungal and antibacterial activity of the synthesized nanoparticles, Minimum inhibitory concentration(MIC), as well as Minimum Fungicidal Concentration(MFC) against the yeast strain Saccharomyces cerevisiae, and Minimum Bactericidal Concentration(MBC) values against bacteria strains, Staphylococcus aureus, Enterococcus faecalis and Escherichia coli were determined. The findings of the study indicated that MP, M3, and M5 nanocomposites displayed a moderate level of antibacterial activity. It is noteworthy, however, that the antibacterial activity diminished when triazole was combined with MP at concentrations exceeding 100 mg/mL.

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Bactericidal evaluation of N-halamine-functionalized silica nanoparticles based on barbituric acid

Cited by 43 publications

References 56 publications

Effect of DksA Protein on the Susceptibility of Escherichia coli Towards Novel Amine N-Halamine Polymeric Nanoparticles as Powerful Antibiotics

Effect of DksA Protein on the Susceptibility of Escherichia coli Towards Novel Amine N-Halamine Polymeric Nanoparticles as Powerful Antibiotics

Construction of silicone with quaternized hydantoin‐based N‐chloramines on cotton with aid of supercritical interpenetration for antibacterial synergism

Antimicrobial Properties of Azole Functional Silica Nanocomposites

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