Modified Uterine Transplant Procedure in the Sheep Model

Ramirez, E.R.; Ramírez, Hugo; Nessetti, D.K. Ramirez; Nessetti, M.B.R.; Pillari, V.T.; Khatamee, M.

doi:10.1016/j.jmig.2008.09.129

Cited by 16 publications

(29 citation statements)

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“…There are reports of auto‐UTx in the 1970s involving a heterotopic grafting technique with vascular anastomosis to the carotid artery and jugular vein . However, UTx in a sheep model really started with the main body of UTx‐related research following the first human attempt in 2000 .…”

Section: Introductionmentioning

confidence: 99%

Achieving uterine auto‐transplantation in a sheep model using iliac vessel anastomosis: a short‐term viability study

Saso

Petts

Thum

et al. 2014

Acta Obstet Gynecol Scand

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Section: Introductionmentioning

confidence: 99%

Achieving uterine auto‐transplantation in a sheep model using iliac vessel anastomosis: a short‐term viability study

Saso

Petts

Thum

et al. 2014

Acta Obstet Gynecol Scand

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“…20 Then, in 2011, Ramirez et al transplanted a uterus in a sheep and demonstrated successful fertility following transplantation. 21 While these early experimental animal models demonstrated the feasibility of uterus transplantation, more preclinical research was necessary before moving to human models.…”

Section: Review Of the Scientific Researchmentioning

confidence: 99%

Ethical considerations in uterus transplantation

Woessner¹,

Blake²,

Arora³

2015

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Uterus transplantation offers a novel treatment option for women with uterine factor infertility. While currently in the early clinical research phase, uterus transplantation will likely provide an alternative to adoption or gestational surrogacy, which is not permitted in some parts of the world. It uniquely allows for women with uterine factor infertility to experience the gestational component of motherhood and also to potentially share a genetic link with the offspring. Clinical research on uterus transplantation has been in process since the 1960s, and the first human live birth following transplant was reported in 2014. However, given the rapid clinical advancement, it is important to review the medical safety of the procedure and ethical dilemmas for the donor, recipient, and resulting child as well as the regulatory landscape that will ultimately guide clinical adoption. Given that uterus transplantation brings together the challenges of both assisted reproductive technology as well as organ transplantation as the world's first ephemeral transplant, it is important to discuss the ethical, legal, and social implications prior to moving from research to widespread clinical practice. Keywords: ethics, regulation, infertility Ethical considerations in uterus transplantationOrgan transplantation has been performed since the early 20th century for a variety of reasons, including restoring function, saving life, and extending lives. Organ transplantation raises its own ethical considerations, including the use of cadaveric or living donors, allocation of scarce resources, use of medical and other criteria to determine eligibility, and informed consent.1-3 Improving the quality of a patient's life, rather than saving life itself, is a more recent goal and achievement of organ transplant (eg, hand, corneal, and face transplants) that presents further ethical considerations.1,3 For example, it is unclear how much risk is justified in the face of interventions aimed at improving quality of life rather than saving life. Uterus transplantation raises these same issues along with novel ones. For example, it is the first organ transplant with the goal being reproduction. Also, uterus transplantation is the first ephemeral organ transplant, or a transplant designed specifically for a short term, rather than the anticipated long-term nature of a transplanted liver or kidney, for example.As a transplant with reproduction as its goal, it necessarily raises ethical questions about technological aid of reproduction, including the rights of any reproductive donors, the interests of the child, commodification of women's bodies, the interests and goals of the mother, and the role of the state in regulating women's bodies and reproduction.

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“…The allogeneic uterus transplantation technique has been better defined with either end-to-end anastomosis of the uterine arteries and veins or anastomosis of an aortacaval patch to the external iliacs (20,21). Progress in composite tissue transplantation has been achieved with the development of new immunosuppressive therapy regimens (22).…”

Section: Uterus Transplantation Researchmentioning

confidence: 99%

Might uterus transplantation be an option for uterine factor infertility?

Akar¹

2015

J Turkish German Gynecol Assoc

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Current data on uterus allotransplantation research has been reviewed and summarized. Over the past 15 years, progress in uterus transplantation research has increased dramatically. As a consequence, the first pregnancy and delivery following uterus allotransplantation in rats have been reported. The technique has been better defined. Although clinical pregnancy and delivery following uterus allotransplantation has been reported in humans, there are still many questions to be answered before clinical application. Gestational surrogacy still remains an important option for being a genetic parent in selected cases with uterine factor infertility. (J Turk Ger Gynecol Assoc 2015; 16: 45-8)

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Modified Uterine Transplant Procedure in the Sheep Model

Cited by 16 publications

References 0 publications

Achieving uterine auto‐transplantation in a sheep model using iliac vessel anastomosis: a short‐term viability study

Achieving uterine auto‐transplantation in a sheep model using iliac vessel anastomosis: a short‐term viability study

Ethical considerations in uterus transplantation

Might uterus transplantation be an option for uterine factor infertility?

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